A5014313084- interferon and immune responses
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Aquaculture disease management and microbiota
- Immune Cell Function and Interaction
- Animal Virus Infections Studies
- Viral Infections and Vectors
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- vaccines and immunoinformatics approaches
- Chemokine receptors and signaling
- Glycosylation and Glycoproteins Research
- Animal health and immunology
- Herpesvirus Infections and Treatments
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Complement system in diseases
- Viral Infections and Immunology Research
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- Coccidia and coccidiosis research
- Animal Genetics and Reproduction
- Toxin Mechanisms and Immunotoxins
University of Alberta
2015-2024
Stanford University
1997-2004
Queen Mary Hospital
1998-1999
University of Hong Kong
1998-1999
Medical University of South Carolina
1992-1995
Dalhousie University
1991-1992
Ducks and wild waterfowl perpetuate all strains of influenza viruses in nature. In their natural host, typically cause asymptomatic infection little pathology. are often resistant to capable killing chickens. Here, we show that the virus sensor, RIG-I, is present ducks plays a role clearing an infection. We evidence suggesting RIG-I may be absent chickens, providing plausible explanation for increased susceptibility compared with ducks. detects RNA ligands derived from uncapped viral...
Ning Li and colleagues report the whole-genome sequence of duck, Anas platyrhynchos, a natural host avian influenza viruses. They examine response to infection by comparing lung transcriptomes ducks that were infected with A The duck (Anas platyrhynchos) is one principal hosts We present genome perform deep transcriptome analyses investigate immune-related genes. Our data indicate possesses contractive immune gene repertoire, as in chicken zebra finch, this repertoire has been shaped through...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of ongoing disease 2019 (COVID-19) pandemic. While previous studies have shown that several SARS-CoV-2 proteins can antagonize interferon (IFN) response, some mechanisms by which they do so are not well understood. In this study, we describe two novel blocks IFN pathway. Type I IFNs and IFN-stimulated genes (ISGs) were poorly induced during infection, once infection was established, cells highly resistant to...
IgY, the major Ab of duck (Anas platyrhynchos), exists in two secreted forms and a transmembrane (TM) form. To investigate genetic relationships multiple IgY we cloned gene encoding (upsilon) heavy chains. The chain smaller (5.7S) which lacks third fourth constant domains, results from use unique terminal exon found intron between second C region exons. Alternate pre-mRNA processing pathways also produce full-length upsilon-chain TM form, each having four domains. Although number secretory...
ABSTRACT Interferon-inducible transmembrane proteins (IFITMs) can restrict the entry of a wide range viruses. IFITM3 localizes to endosomes and potently replication influenza A viruses (IAV) several other that also enter host cells through endocytic pathway. Here, we investigate whether IFITMs are involved in protection ducks, natural virus. We identify sequence duck IFITM1 , IFITM2 IFITM5 . Using quantitative PCR (qPCR), demonstrate upregulation these genes lung tissue response highly...
Abstract MHC class I proteins mediate a variety of functions in antiviral defense. In humans and mice, three loci each contribute one or two alleles can present wide peptide Ags. contrast, many lower vertebrates appear to use single locus. Previously we showed that locus was predominantly expressed the mallard duck (Anas platyrhynchos) adjacent polymorphic transporter for Ag-processing (TAP2) gene. Characterization genomic clone from same now allows us compare genes account their...
Abstract HLA-A*2402 is common and widely distributed in human populations. Several individuals were identified who type genotypically for A*2402, but are serologically null the HLA-A24 Ag. Sequencing transfection of genomic DNA fragments containing wild-type A*2402 alleles, related A*2301 allele, revealed three different alleles (A*2409N, A*2411N, A*2402(low)), each which differs from by a single nucleotide change within 6.7-kb sequence. The sequences differ no substitutions additional to...
Ducks, the reservoir host, are generally permissive to influenza A virus infection without disease symptoms. This natural ecology was upset by emergence of H5N1 strains, which can kill ducks. To better understand host-virus interactions in and strain-specific molecular contributions virulence, we infected White Pekin ducks with three similar viruses, known differences pathogenicity replication rate. We quantified viral innate immune gene activation qPCR, lung spleen tissues, isolated on each...
Soluble epoxide hydrolase (sEH) is an essential enzyme for converting epoxy fatty acids to their less bioactive diols. Our study suggests deletion or inhibition of sEH impacts the aging process in hearts female mice resulting cardioprotection. Data indicate targeting limits inflammation, preserves mitochondria, and alters cellular senescence aged heart.