A5052551879- Influenza Virus Research Studies
- interferon and immune responses
- Immune Response and Inflammation
- Parasites and Host Interactions
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Parasitic infections in humans and animals
- Reproductive System and Pregnancy
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Mitochondrial Function and Pathology
- Insect and Pesticide Research
- Herpesvirus Infections and Treatments
- Animal Ecology and Behavior Studies
- Receptor Mechanisms and Signaling
- Extracellular vesicles in disease
- Urological Disorders and Treatments
- Parasite Biology and Host Interactions
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Neuroendocrine regulation and behavior
- Viral gastroenteritis research and epidemiology
- vaccines and immunoinformatics approaches
- Parasitic Infections and Diagnostics
- Trypanosoma species research and implications
St. Jude Children's Research Hospital
2008-2018
McGill University
2014-2018
Wake Forest University
2006-2007
Ducks and wild waterfowl perpetuate all strains of influenza viruses in nature. In their natural host, typically cause asymptomatic infection little pathology. are often resistant to capable killing chickens. Here, we show that the virus sensor, RIG-I, is present ducks plays a role clearing an infection. We evidence suggesting RIG-I may be absent chickens, providing plausible explanation for increased susceptibility compared with ducks. detects RNA ligands derived from uncapped viral...
Respiratory infection with highly pathogenic influenza A viruses is characterized by the exuberant production of cytokines and chemokines enhanced recruitment innate inflammatory cells. Here, we show that challenging mice virulent viruses, including currently circulating H5N1 strains, causes increased selective accumulation a particular dendritic cell subset, tipDCs, in pneumonic airways. These tipDCs are required for further proliferation influenza-specific CD8(+) T cells infected lung,...
Ning Li and colleagues report the whole-genome sequence of duck, Anas platyrhynchos, a natural host avian influenza viruses. They examine response to infection by comparing lung transcriptomes ducks that were infected with A The duck (Anas platyrhynchos) is one principal hosts We present genome perform deep transcriptome analyses investigate immune-related genes. Our data indicate possesses contractive immune gene repertoire, as in chicken zebra finch, this repertoire has been shaped through...
Exosomes are small vesicles of endocytic origin, which released into the extracellular environment and mediate a variety physiological pathological conditions. Here we show that Schistosoma mansoni releases exosome-like in vitro. Vesicles were purified from culture medium by sucrose gradient fractionation fractions containing verified western blot analyses electron microscopy. Proteomic exosomal contents unveiled 130 schistosome proteins. Among these proteins common markers such as heat...
In Egypt, efforts to control highly pathogenic H5N1 avian influenza virus in poultry and humans have failed despite increased biosecurity, quarantine, vaccination at farms. The ongoing circulation of HP Egypt has caused >100 human infections remains an unresolved threat veterinary public health. Here, we describe that the failure commercially available H5 vaccines may be part by passive transfer maternal antibodies chicks, inhibiting their immune response vaccination. We propose induction...
The vacuolar (H+)-ATPases (V-ATPases) facilitate the release of influenza A virus (IAV) genome into cytoplasm by acidifying endosomal interior. regulation V-ATPases signalling pathways has been demonstrated in various model systems. However, little is known about signalling-regulated V-ATPase activation during IAV infection. Here we show that activity elevated infection cell monolayers with IAV, as measured intracellular pH change, via a mechanism mediated extracellular signal-regulated...
The HA of influenza virus is a receptor-binding and fusion protein that required to initiate infection. domain determines the species sialyl receptors recognized by viruses. Here, we demonstrate changes in alter ability H5N1 spread systemically mice. A/Vietnam/1203/04 (VN1203) A/Hong Kong/213/03 (HK213) viruses are consistently lethal domestic chickens but differ their pathogenicity mammals. Insertion VN1203 neuraminidase (NA) genes into recombinant HK213 expanded its tissue tropism...
ABSTRACT Pandemic A (H1N1) 2009 influenza virus (pH1N1) infection in pregnant women can be severe. The mechanisms that affect outcome this population are not well understood. To address this, and nonpregnant BALB/c mice were inoculated with the wild-type pH1N1 strain A/California/04/09. determine whether innate immune responses associated severe infection, we measured cells trafficking into lungs of versus animals. Increased infiltration pulmonary neutrophils macrophages strongly correlated...
Please cite this paper as: Moseley et al. (2010) Peroxisome proliferator‐activated receptor and AMP‐activated protein kinase agonists protect against lethal influenza virus challenge in mice. Influenza Other Respiratory Viruses 4(5), 307–311. Background A novel (H1N1) was isolated from humans North America has developed into the first pandemic of 21st century. Reports a global shortage antiviral drugs, evolution drug‐resistant variants, 6‐month delay vaccine availability underline need to...
Although the presence of intact host proteins in cyst fluid cyclophyllidean metacestodes has been well documented, underlying reason for protein uptake is poorly understood. To investigate this discrepancy, both (CF) and excreted/secreted (E/ S) were collected vitro from Taenia crassiceps 16 wk postinfection Balb/cJ female mice. The CF E/S subsequently immunoblotted using rabbit anti-mouse whole serum antibodies as a probe. results show that not only internalized by but also secreted well....
Balb/cJ mice infected in the peritoneal cavity with larval Taenia crassiceps fail to mount a protective immune response. In mice, inflammatory responses are believed control reproduction, whereas antibody-mediated be permissive. present study, were treated CpG-oligodeoxynucleotides (CpG) determine whether stimulation of innate response would confer increased resistance growth. Female CpG displayed decrease mean parasite burden by 54%, while male 73% reduction. Moreover, 5 12 CpG-treated...
Balb/cJ mice fail to mount an immune response capable of clearing infection with larval Taenia crassiceps. Additionally, male display a lag in growth approximately 3 wk as compared female mice. It has been reported that Balb/ cAnN generate protective early infection, and become permissive after they feminize (200-fold increase serum estradiol 90% decrease testosterone). To determine if different strain Balb/c (Balb/cJ) also feminize, was collected from infected for 16 levels...
Abstract Pandemic H1N1 2009 Influenza A virus (pH1N1) infection in pregnant or postpartum women is quite severe. The immunological mechanisms that affect outcome these populations are not well understood. To address this, Balb/c and non-pregnant mice were inoculated with a wild-type pH1N1 virus. We determined early cytokine responses impaired mouse lungs. Moreover, pulmonary infiltration of neutrophils macrophages strongly correlated an increase mortality mice. Increased animals was...