A5100714659- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Vanadium and Halogenation Chemistry
- Synthesis and Characterization of Heterocyclic Compounds
- Migraine and Headache Studies
- Ophthalmology and Eye Disorders
- Organometallic Compounds Synthesis and Characterization
- Metal-Catalyzed Oxygenation Mechanisms
- Crystallography and molecular interactions
- Crystal structures of chemical compounds
- Synthesis and biological activity
- RNA Research and Splicing
- Polyomavirus and related diseases
- RNA regulation and disease
- Extraction and Separation Processes
- Epigenetics and DNA Methylation
- Infectious Diseases and Mycology
- Sympathectomy and Hyperhidrosis Treatments
- Radiopharmaceutical Chemistry and Applications
- Endometrial and Cervical Cancer Treatments
- Chemotherapy-related skin toxicity
- Acute Lymphoblastic Leukemia research
- Cancer Treatment and Pharmacology
- Magnetism in coordination complexes
Universidad Nacional de La Plata
2017-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2023
Comisión de Investigaciones Científicas
2023
Biomedical Research Institute of Lleida
2016-2023
Centro Científico Tecnológico - La Plata
2019-2021
Hospital Universitario de La Princesa
2017
Rede de Química e Tecnologia
2017
Centro Científico Tecnológico - Tucumán
2017
Hospital Universitari Arnau de Vilanova
2016
Universitat de Lleida
2016
Tumor necrosis factor (TNF) is regulated post-transcriptionally by the AU-rich element (ARE) within 3'-untranslated region of its mRNA. This regulation modulates translational efficacy and mRNA stability. By using a cRNA probe containing TNF ARE sequence, we screened macrophage protein expression library identified FXR1P. Macrophages that generated from FXR1 knock-out mice had enhanced production compared with wild type macrophages following activation. Expression several other proteins are...
Abstract The purpose of this work was to screen the antitumor actions two metal organoruthenium-8-hydroxyquinolinato (Ru-hq) complexes find a potential novel agent for bone, lung and breast chemotherapies. We showed that ruthenium compounds (1 2) impaired cell viability human bone (MG-63), (A549) (MCF7) cancer cells with greater selectivity specificity than cisplatin. Besides, 1 2 decreased proliferation, migration invasion on monolayers at lower concentrations (2.5–10 μM). In addition, both...
[Cu(dmp)<sub>2</sub>(CH<sub>3</sub>CN)]<sup>2+</sup> can be reduced in acetonitrile containing water due to steric constraints of the ligands. Hydroxyl radicals are produced from oxidation. We take advantage this reaction evaluate anticancer activity complex.
The main goal of this work was to screen the antiproliferative activity and mechanism actions two copper complexes: [Cu(dmp)2(CH3CN)]2+ (1) [Cu(phen)2(CH3CN)]2+ (2) on 2D 3D colorectal cancer cells models. Cell viability studies three cell lines (HT-29, LS174T, Caco-2) displayed that 1 showed more robust than 2 cisplatin. Intracellular content (63.24% 48.06% for 2, respectively) can explain differences in cytotoxicity assay. ROS production is primary action involved showing 4-, 70- 2.5- fold...
Pd(<sc>ii</sc>) and P(<sc>ii</sc>) thiosemicarbazone complexes with high selectivity towards cancer cells a novel biological interaction profile.
In developed countries, endometrial carcinoma is the most common cancer that affects female genital tract. Endometrial divided into two main histological types, type I or endometrioid and II non-endometrioid, each of which have characteristic, although not exclusive, molecular alterations mutational profiles. Nevertheless, information about implication relevance some these genes in this disease lacking. We sought here to identify new recurrently mutated cancers play a role tumourigenesis...
Parameters affecting the kinetics of dissolution β-spodumene with hydrofluoric acid have been investigated. The experimental tests were carried out in a closed vessel. influence several parameters, such as stirring speed, temperature, and reaction time studied order to deduce reaction. other particle size −45 μm; HF concentration 4% v/v, solid–liquid ratio 0.95% w/v kept constant. results indicate that speed does not an important effect on mineral above 330 rpm. extent leaching increases...
A combined experimental and theoretical study cytotoxicity assays of diethylaminophenyl-based Schiff base Cu(<sc>ii</sc>) VO(<sc>iv</sc>) complexes are reported. The complex shows interesting chelate ring⋯π interactions in the crystal structure.
Freeze-dried Chrys-loaded BSAnp retained their properties after reconstitution and induced apoptosis on breast cancer cells. BSAnp-70-11 (smallest sized) was the most cytotoxic system with a gastrointestinal release of 14% Chrys.
A new Metvan-NLC compound was developed to improve Metvan's biopharmaceutical profile and antitumor efficacy.
The purpose of this phase II randomised trial was to determine which two schemes, raltitrexed-irinotecan or raltitrexed-oxaliplatin, offered better activity and less toxicity in patients with advanced colorectal cancer (CRC). A total 94 previously untreated metastatic CRC were included receive raltitrexed 3 mg m−2 followed by oxaliplatin 130 on day 1 (arm A), CPT-11 350 B). In both arms treatment repeated every weeks. Intent-to-treat (ITT) analysis showed an overall response rate 46% (95%...
The purpose of this study is to evaluate the neuropsychological performance in a ≥90-year-old population with Alzheimer disease (AD) comparison younger elderly patients. We retrospectively studied all patients AD attended specialized clinic between 1999 and 2011. Age, sex, educational level, sensory loss data were collected. Neuropsychological evaluation included Mini-Mental State Examination Global Deterioration Scale. used eight Cambridge Cognitive Assessment (CAMCOG-R) domains compare...
Food allergies have become a health concern worldwide. Around 6% to 10% of children are allergic cow's milk proteins. We previously characterized colorectal polyps in patients sensitized food allergens. These classified as inflammatory and present type 2 environment, with elevated interleukin (IL)-13 IL-4, site immunoglobulin E synthesis. In this study, we isolated protein-specific T cell lines clones from the lamina propria these Isolated cells responded proteins similarly peripheral blood...