A5049644495- Neuroscience and Neural Engineering
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Biomedical and Engineering Education
- Cellular transport and secretion
- Neuroscience and Neuropharmacology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Photoreceptor and optogenetics research
- Nanofabrication and Lithography Techniques
- Advanced Drug Delivery Systems
- Quantum Dots Synthesis And Properties
- Microtubule and mitosis dynamics
- Pluripotent Stem Cells Research
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Nerve injury and regeneration
- Monoclonal and Polyclonal Antibodies Research
- Click Chemistry and Applications
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Advanced Sensor and Energy Harvesting Materials
- Epigenetics and DNA Methylation
University of Genoa
2020-2024
March of Dimes
2023
Ingegneria dei Sistemi (Italy)
2020-2021
Abstract In situ bioprinting—the process of depositing bioinks at a defected area, has recently emerged as versatile technology for tissue repair and restoration via site-specific delivery pro-healing constructs. The ability to print multiple materials in is an exciting approach that allows simultaneous or sequential dispensing different cells achieve biomimicry. Herein, we report modular handheld bioprinter deposits variety with exquisite control over their physical chemical properties....
Introduction: The secretome of mesenchymal stromal cells (MSCs) serves as an innovative tool employed in the regenerative medicine approach. In this particular context, three-dimensional (3D) culture systems are widely utilized to better replicate vivo conditions and facilitate prolonged cell maintenance during culture. use spheroids enables preservation classical phenotypical characteristics MSCs. However, distinct microenvironment within spheroid may impact secretome, thereby enhancing...
Abstract Objective. In this work we adapted a protocol for the fast generation of human neurons to build 3D neuronal networks with controlled structure and cell composition suitable systematic electrophysiological investigations. Approach. We used biocompatible chitosan microbeads as scaffold ensure nutrients-medium exchange from core external environment. excitatory derived human-induced pluripotent stem cells (hiPSCs) co-cultured astrocytes. By adapting well-established NgN2...
Neratinib (NE) is an irreversible pan-ERBB tyrosine kinase inhibitor used to treat breast cancers (BCa) with amplification of the ERBB2/HER2/Neu gene or overexpression ERBB2 receptor. However, mechanisms behind this process are not fully understood. Here we investigated effects NE on critical cell survival processes in ERBB2+ cancer cells. By kinome array analysis, showed that time-dependently inhibited phosphorylation two distinct sets kinases. The first set, including downstream signaling...
Breast cancer is a significant global health concern, with the overexpression of human epidermal growth factor receptor 2 (HER2/ERBB2) being driver oncogene in 20%–30% cases. Indeed, HER2/ERBB2 plays crucial role regulating cell growth, differentiation, and survival via complex signaling network. Overexpression associated more aggressive behavior increased risk brain metastases, which remains clinical challenge for treatment. Recent research has highlighted breast secretomes promoting tumor...
Current treatment strategies for glioblastoma (GBM) including surgical resection and adjuvant radio/chemotherapy result in a limited progression-free survival time of patients due to rapidly occurring tumor recurrences. The urgent need more effective treatments has led the development different approaches localized drug delivery systems (DDSs) offering advantages reduced systemic side effects. A promising candidate GBMs is AT101, R-(-)-enantiomer gossypol its ability induce apoptosis or...
Abstract Three‐dimensional (3D) spheroid models aim to bridge the gap between traditional two‐dimensional (2D) cultures and complex in vivo tissue environment. These models, created by self‐clustering cells mimic a 3D environment with surrounding extracellular framework, provide valuable research tool. The NSC‐34 cell line, generated fusing mouse spinal cord motor neurons neuroblastoma cells, is essential for studying neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), where...
The aim of this work was to demonstrate chitosan micropatterning effectiveness realize spatially guided 2D neuronal networks primary rat neurons and derived from human induced pluripotent stem cells (h-iNeurons). Morphological characterizations were carried out validate the formation a well-defined networks.
Approximately 20%–30% of breast cancers (BCa) harbor amplification the ERBB2/HER2/Neu gene or overexpression ERBB2 receptor. Neratinib (NE) is an irreversible pan-ERBB tyrosine kinase inhibitor that causes survival inhibition ERBB2+ cancer cells and currently approved only for BCa. Autophagy mitochondrial homeostasis are physiological processes exploited by to survive controlled TFEB TFE3 transcription factors. Whether NE affects autophagy bioenergetics suppress progression/dissemination...