A5100377902- Advanced MRI Techniques and Applications
- Neonatal and fetal brain pathology
- Lanthanide and Transition Metal Complexes
- Atomic and Subatomic Physics Research
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Mitochondrial Function and Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Nanoplatforms for cancer theranostics
- Fetal and Pediatric Neurological Disorders
- Radiomics and Machine Learning in Medical Imaging
- EEG and Brain-Computer Interfaces
- Electron Spin Resonance Studies
- Lung Cancer Diagnosis and Treatment
- Biochemical effects in animals
- Digital Radiography and Breast Imaging
- Pregnancy and preeclampsia studies
- Pharmacological Effects and Toxicity Studies
- Neonatal Health and Biochemistry
- Glioma Diagnosis and Treatment
- S100 Proteins and Annexins
- AI in cancer detection
- Pancreatic and Hepatic Oncology Research
Xijing Hospital
2024
Air Force Medical University
2024
Affiliated Hospital of North Sichuan Medical College
2009-2024
Henan Provincial Chest Hospital
2024
Zhengzhou University
2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Tianjin University of Traditional Chinese Medicine
2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
China Medical University
2009-2023
Fusobacterium nucleatum (F. nucleatum) is a gut microbe implicated in gastrointestinal tumorigenesis. Predicting the chemotherapeutic response critical to developing personalised therapeutic strategies for oesophageal cancer patients. The present study investigated relationship between F. and resistance squamous cell carcinoma (ESCC).We examined chemotherapy 120 ESCC resected specimens 30 pre-treatment biopsy specimens. In vitro studies using lines co-culture assays further uncovered...
Nanoprobes that offer both fluorescence imaging (FI) and magnetic resonance (MRI) can provide supplementary information hold synergistic advantages. However, synthesis of such dual-modality probes simultaneously exhibit tunability functional groups, high stability, great biocompatibility desired results remains challenging. In this study, we used an amphiphilic block polymer from (ethylene glycol) methyl ether methacrylate (OEGMA) N-(2-hydroxypropyl) methacrylamide (HPMA) derivatives as a...
A ROX and enzyme-responsive biodegradable gadolinium-based mCA was prepared, demonstrating a short gadolinium retention time sufficient MRI contrast efficacy in tumors.
To evaluate the efficacy of three-dimensional (3D) segmentation-based radiomics analysis multiparametric MRI combined with proton magnetic resonance spectroscopy (1 H-MRS) and diffusion tensor imaging (DTI) in glioma grading.A total 100 patients histologically confirmed gliomas (grade II-IV) were examined using conventional MRI, 1 H-MRS, DTI. Tumor segmentations T1-weighted (T1WI), contrast-enhanced T1WI (T1WI+C), T2-weighted (T2WI), apparent coefficient (ADC) mapping, fractional anisotropy...
<h3>BACKGROUND AND PURPOSE:</h3> As amide proton transfer imaging is sensitive to protein content and intracellular pH, it has been widely used in the nervous system, including brain tumors stroke. This work aimed measure lactate values basal ganglia of a neonatal piglet hypoxic-ischemic injury model by using MR spectroscopy imaging. <h3>MATERIALS METHODS:</h3> From 58 healthy piglets (3–5 days after birth; weight, 1–1.5 kg) selected initially, 9 remained control group 43 piglets, group....
Many studies have shown that healthy elderly subjects and patients with Alzheimer's disease (AD) who carry the apolipoprotein E (ApoE) ε4 allele worse cognitive function more severe brain atrophy than non-carriers. However, it remains unclear whether this ApoE polymorphism leads to changes of cognition morphology in young adults. In study, we used an established model measure verbal episodic memory core executive (EF) components (response inhibition, working task switching) 32 carriers 40...
Working memory functions are known to be altered after total sleep deprivation (TSD). However, few studies have explored the deficits of working updating (WMU) TSD, or underlying electrophysiological mechanisms these alterations. In current exploratory study, we enrolled 14 young male volunteers who performed two kinds WMU tasks-spatial and object two-back tasks-with simultaneous electroencephalography recordings under conditions: a normal baseline condition 36 h TSD. Repeated-measures...
Objective. In order to evaluate the potential use of bupropion as smoking cessation therapy during pregnancy, aim this investigation was determine transplacental transfer and metabolism its distribution among placental tissue maternal fetal circuits dually perfused lobule.
Maintaining glutamate homeostasis after hypoxic ischemia is important for synaptic function and neural cell activity, regulation of transport between astrocyte neuron one the modalities reducing accumulation. However, further research needed to investigate dynamic changes in molecular mechanisms effects on synapses. The aim this study was regulatory underlying Notch pathway mediation plasticity. In study, Yorkshire neonatal pigs (male, age 3 days, weight 1.0–1.5 kg, n = 48) were randomly...
<h3>BACKGROUND AND PURPOSE:</h3> The neonatal brain has active energy metabolism, and glucose oxidation is the major source of tissue. Lactate produced by astrocytes released to neurons. In central nervous system, lactate transported between neurons via astrocyte-neuron shuttle. aim this study was investigate regulatory mechanisms metabolism in basal ganglia a hypoxic-ischemic injury piglet model. <h3>MATERIALS METHODS:</h3> A total 35 healthy piglets (3–5 days age; 1.0–1.5 kg) were assigned...
The brain's hemodynamic and metabolism of punctate white matter lesions (PWML) is poorly understood due to a scarcity non-invasive imaging techniques. aim this study was apply new MRI techniques quantify cerebral metabolic rate oxygen (CMRO2), global blood flow (CBF), saturation fractions in venous (Yv) extraction fraction (OEF) neonates with PWML, for better understanding the pathophysiology PWML. Fifty-one newborns were recruited continuously, including 23 neonatal patients PWML 28 normal...
Purpose. This study aims to evaluate the process of brain development in neonates using combined amide proton transfer (APT) imaging and conventional magnetization (MT) imaging. Materials Methods. Case data were reviewed for all patients hospitalized our institution's neonatal ward. Patients underwent APT MT (a single protocol) immediately following routine MR examination. Single-slice APT/MT axial was performed at level basal ganglia. ratio (MTR) measurements multiple regions interest...
We assessed the correlation between iron deposition and change of gliocyte metabolism in healthy subjects' basal ganglia region, by using 3D-enhanced susceptibility weighted angiography (ESWAN) proton magnetic resonance spectroscopy ((1)H-MRS).Seventy-seven volunteers (39 female 38 male subjects; age range: 24-82 years old) were enrolled experiment including ESWAN MRS sequences, consent for which was provided themselves or their guardians. For each subject, mean phase value gained used to...
Administration of non-thermal plasma therapy via the use plasma-activated medium (PAM) might be a novel strategy for cancer treatment, as it induces apoptosis by increasing reactive oxygen species (ROS) levels. Peroxiredoxin V (PRDX5) scavenges ROS and nitrogen is known to regulate several physiological pathological reactions. However, its role in lung cells exposed PAM unknown. Here, we investigated effect PRDX5 PAM-treated A549 determined mechanism underlying cytotoxicity. Cell culture was...
The excitotoxicity of glutamate metabolism as well hemodynamic disorders the brain are both risk factors for neonatal hypoxic–ischemic damage (HIBD). In present study, changes in basal ganglia were detected by 1H-MRS at 0–6 h, 8–12 24–30 h and 48–60 after induction hypoxia-ischemia (HI) newborn piglets. Meanwhile, correlation analysis was performed combining microcirculatory perfusion informations acquired intravoxel incoherent motion (IVIM) scan to explore their possible interaction...
Recent in vitro data obtained our laboratory revealed similarities between baboons and humans the biotransformation of bupropion (BUP) by both hepatic placental microsomes. These supported use to study BUP during pregnancy. The aim this investigation was determine pharmacokinetics pregnancy postpartum, as well fetal exposure drug after intravenous administration. Pregnant (<i>n</i> = 5) received a single bolus dose hydrochloride (1 mg/kg) at gestational ages 94–108 days (midpregnancy),...
This study aimed to characterize the morbidity, hospitalization, and mortality rates among patients with adult-onset Still's disease (AOSD) affected by coronavirus 2019 (COVID-19) explore impact of COVID-19 on activity AOSD. Data clinical demographic characteristics, COVID-19-related symptoms, outcomes were retrospectively collected. Patients stratified according severity associations between risk factors analyzed using multivariate logistic regression. The AOSD flares after was described. A...