A5020392344- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microbial Metabolism and Applications
- Plant Disease Resistance and Genetics
- Extracellular vesicles in disease
- Peanut Plant Research Studies
- Food Quality and Safety Studies
- Agronomic Practices and Intercropping Systems
- Plant Gene Expression Analysis
- Urinary Bladder and Prostate Research
- Colorectal Cancer Treatments and Studies
- Protein Hydrolysis and Bioactive Peptides
- Plant nutrient uptake and metabolism
- Immune Cell Function and Interaction
First Affiliated Hospital of Wenzhou Medical University
2016-2025
Wenzhou Medical University
2016-2025
Shenyang Pharmaceutical University
2024-2025
First Affiliated Hospital of Soochow University
2022-2024
Soochow University
2022-2024
Linyi University
2022-2023
Hubei University of Science and Technology
2022
Wenzhou City People's Hospital
2014
Increasing evidences have suggested that natural killer (NK) cells in the tumor microenvironment are involved regulation of cancer development. However, potential biological roles and regulatory mechanisms NK pancreatic (PC) remain unclear. Co-culture system with PC is used to test ability cell proliferation, migration invasion both
Luteolin, a flavone, has been shown to exhibit anticancer properties. Here, we investigated whether luteolin affects epithelial-mesenchymal transition (EMT) and invasiveness of pancreatic cancer cell lines their underlying mechanism. Pancreatic PANC-1 SW1990 were used in our study, EMT characters, matrix metalloproteinase (MMP) expression level, invasiveness, signal transducer activator transcription 3 (STAT3) activity determined after treatment. We also treated cells with interleukin-6...
Heterogeneous nuclear ribonucleoprotein A2B1 (HNRNPA2B1) is closely related to tumour occurrence and development, oncogene expression, apoptosis inhibition invasion metastasis capacities. However, its function in the epithelial-mesenchymal transition (EMT) of pancreatic cancer not fully understood.By comparing various wild-type cell lines, we determined which have a higher expression level HNRNPA2B1 accompanied by N-cadherin vimentin lower E-cadherin. Therefore, elucidate role EMT, generated...
The clinical efficacy of current therapies for Hepatocellular carcinoma (HCC) are unsatisfactory. In recent years, chimeric antigen receptor (CAR) T-cell have been developed solid tumors including advanced HCC (aHCC), but limited progress has made. Glypican-3 is a promising immunotherapeutic target since it specifically highly expressed in HCC. A previous study indicated that GPC3-targeted CAR T-(CAR-GPC3) cells were well-tolerated and had prolonged survival patients Sorafenib could increase...
Two-component system (TCS), which comprises histidine kinases (HKs), phosphotransfer proteins (HPs), and response regulators (RRs), plays essential roles in regulating plant growth, development, to various environmental stimuli. TCS genes have been comprehensively identified plants, while studies on the genome-wide identification analysis of sweet potato were still not reported. Therefore, this study, a total 90 members consisting 20 HK(L)s, 11 HPs, 59 RRs genome Ipomoea batatas....
Abstract: Isoorientin (or homoorientin) is a flavone, which chemical flavonoid-like compound, and 6-C-glucoside of luteolin. has been demonstrated to have anti-cancer activities against various tumors, but its effects on pancreatic cancer (PC) not studied in detail. In this study, we aim investigate whether isoorientin potential anti-PC underlying mechanism. PC, strongly inhibited the survival cells, induced cell apoptosis, decreased malignancy by reversing expression epithelial–mesenchymal...
Abstract Purpose: This phase II, multicenter, prospective, single-arm study aimed to evaluate the efficacy and safety of toripalimab plus bevacizumab for treating advanced hepatocellular carcinoma (HCC). Patients Methods: Treatment-naïve patients with HCC received 240 mg 15 mg/kg every 3 weeks. The primary endpoints included tolerability objective response rate (ORR) assessed by investigator per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. Results: Fifty-four were...
Background Hepatocellular carcinoma (HCC) accounts for over 80% of primary liver cancers and is the third leading cause cancer-related deaths worldwide. Hepatitis B virus (HBV) infection etiological factor. Disulfidptosis a newly discovered form regulated cell death. This study aims to develop novel HBV-HCC prognostic signature related disulfidptosis explore potential therapeutic approaches through risk stratification based on disulfidptosis. Methods Transcriptomic data from patients were...
Abstract Purinergic P2Y2 receptor (P2Y2R) represents a typically extracellular ATP and UTP sensor for mediating purinergic signaling. Despite its importance as pharmacological target, the molecular mechanisms underlying ligand recognition G-protein coupling have remained elusive due to lack of structural information. In this study, we determined cryo-electron microscopy (cryo-EM) structures apo P2Y2R in complex with G q , ATP-bound or o UTP-bound P2Y4R . These reveal similarities...
Abstract Xeroderma pigmentosum group G ( XPG ) protein plays an important role in the DNA repair process by cutting damaged at 3′ terminus. Previous studies have indicated some polymorphisms gene are associated with stomach cancer susceptibility. We performed this hospital‐based case–control study to evaluate association of four potentially functional (rs2094258 C>T, rs751402 rs2296147 T>C and rs873601G>A) The single nucleotide SNP s) were genotyped 692 cases 771 healthy controls....
Hepatocellular carcinoma (HCC) is the most common type among primary liver cancers (PLC). With its poor prognosis and survival rate, it necessary for HCC patients to have a long-term follow-up. We believe that there are currently no relevant reports or literature about nomograms predicting cancer-specific mortality of patients. Therefore, goal this study was develop evaluate predict overall mortality. Data 45,158 cases were collected from Surveillance, Epidemiology, End Results (SEER)...
Laminin is an extracellular matrix molecule that the major component of basement membrane and plays a key role in regulating various processes. However, association between laminin gene family prognosis pancreatic carcinoma has not been systematically investigated.
Our previous studies verified the potent anti-inflammatory effects against severe acute pancreatitis (SAP) of AT-Lipoxin A4 and their analogues. However, on SAP-associated lung injury are not thoroughly known. We used western blot, polymerase chain reaction (PCR), immunofluorescence to investigate downregulation TNF- α signals in cellular animal models following intervention. In vitro , we found that markedly suppressed protein expression human pulmonary microvascular endothelial cell, such...
Abstract Background Patients with severe acute pancreatitis (SAP) have a high mortality, thus early diagnosis and interventions are critical for improving survival. However, conventional tests limited in (AP) stratification. We aimed to assess AP severity by integrating the informative clinical measurements cell free DNA (cfDNA) methylation markers. Methods One hundred seventy-five blood samples were collected from 61 patients at multiple time points, plus 24 healthy individuals. Genome-wide...
Phosphorus (P) is essential for living plants. P deficiency one of the key factors limiting rapeseed yield production worldwide. As most important organs plants, root morphology traits (RMTs) play a role in absorption. To investigate genetic variability RMT under low availability, we dissected structure RMTs bygenome-wide association studies (GWAS), linkage mapping and candidate gene (CGAS). A total 52 suggestive loci were detected associated with stress conditions 405 oilseed rape. The...
Luteolin, a flavone, has been demonstrated to have anti‑cancer properties. In the current study, effects of luteolin on certain carcinogenesis‑associated changes induced by pancreatitis, which are significant risk factors for pancreatic cancer, were investigated. Male six‑week‑old C57BL6 mice used in study divided into three groups; control group, acute pancreatitis group and group. Intra‑peritoneal injection cearulein was performed induce whereas received intra‑peritoneal luteolin. The...
435 Background: Anti-PD-1/PD-L1 combining with antiangiogenic agents has showed encouraging anti-tumor efficacy for treating advanced hepatocellular carcinoma (HCC). Toripalimab, a humanized monoclonal antibody against PD-1, already been approved melanoma, nasopharyngeal and urothelial in China. Therefore, we aimed to assess the safety of toripalimab plus bevacizumab as first-line treatment unresectable HCC. Methods: This is multicenter, single-arm, open-label, phase II study. Patients...
This study aimed to investigate the effects of geniposide(GP) on expression prokineticin(PK2) and prokineticin receptor 1(PKR1) in db/db mice with diabetic nephropathy(DN), so as explore how PK2 signaling pathway participated pathological changes DN whether GP exerted therapeutic effect through this pathway. Male were randomly divided into four groups, namely db/m, db/db, db/db+GP, db/m+GP five each group. The db/db+GP groups gavaged 150 mg·kg~(-1) for eight successive weeks. Afterwards, all...