A5039184636- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Testicular diseases and treatments
- Urologic and reproductive health conditions
- Hernia repair and management
- Urinary Bladder and Prostate Research
- Genital Health and Disease
- Congenital Diaphragmatic Hernia Studies
- Sperm and Testicular Function
- Sexual Differentiation and Disorders
- Urinary and Genital Oncology Studies
- Ureteral procedures and complications
- Renal and related cancers
- Gynecological conditions and treatments
- Neuroblastoma Research and Treatments
- Congenital gastrointestinal and neural anomalies
- Gastrointestinal disorders and treatments
- Congenital Anomalies and Fetal Surgery
- Diabetes Treatment and Management
- Neurofibromatosis and Schwannoma Cases
- Adenosine and Purinergic Signaling
- Cardiac Ischemia and Reperfusion
- Adrenal and Paraganglionic Tumors
- Bladder and Urothelial Cancer Treatments
- Neonatal Respiratory Health Research
University of Messina
2016-2025
Istituto Ortopedico Gaetano Pini
2016-2024
University of Catania
2006-2023
Ospedale Santa Maria
2022
Azienda Ospedaliera di Perugia
2008-2019
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2018
University of Perugia
2001-2016
Royal Manchester Children's Hospital
2011-2012
Misericordia University
2011
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele
2010-2011
A network of endometriosis experts from 16 Italian academic departments and teaching hospitals distributed all over the country made a critical appraisal available evidence definition 10 suggestions regarding measures to be de-implemented. Strong were only when high-quality was available. The aim select low-value medical interventions, characterized by an unfavorable balance between potential benefits, harms, costs, which should discouraged in women with endometriosis. following agreed...
Inflammation plays a key role in the development of benign prostatic hyperplasia (BPH). Eicosanoids derived from COX and 5-lipoxygenase (5-LOX) pathways are elevated enlarging prostate. Flavocoxid is novel flavonoid-based 'dual inhibitor' 5-LOX enzymes. This study evaluated effects flavocoxid experimental BPH.Rats were treated daily with testosterone propionate (3 mg·kg(-1) s.c.) or its vehicle for 14 days to induce BPH. Animals receiving randomized receive (1 mL·kg(-1) , i.p.) (20 days....
Testicular torsion or of the spermatic cord is one most serious urological conditions. It causes testicular injury, which potentially leads to male subfertility. The turning and structures around themselves results in biochemical histological changes; however, following detorsion, tissues undergo reperfusion that more severe damage than induced by ischemia. Since primary are reactive oxygen species production, an increase intra-mitochondrial calcium concentration increased rate cellular...
Abstract Background The apoptosis machinery is a promising target against benign prostatic hyperplasia (BPH). Inhibitors of proteins (IAPs) modulate by direct inhibition caspases. Serenoa Repens (SeR) may be combined with other natural compounds such as Lycopene (Ly) and Selenium (Se) to maximize its therapeutic activity in BPH. We investigated the effects SeR, Se Ly, alone or association, on expression four IAPs, cIAP-1, cIAP-2, NAIP survivin rats experimental testosterone-dependent...
Abstract Cadmium (Cd) causes male infertility. There is the need to identify safe treatments counteracting this toxicity. Flavocoxid a flavonoid that induces balanced inhibition of cyclooxygenase (COX)-1 and COX-2 peroxidase moieties 5-lipoxygenase (LOX) has efficacy in genitourinary system. We investigated flavocoxid effects on Cd-induced testicular toxicity mice. Swiss mice were divided into 4 groups: 2 control groups received 0.9% NaCl (vehicle; 1 ml/kg/day) or (20 mg/kg/day ip);...
Balanitis xerotica obliterans (BXO) is a chronic inflammatory skin disorder, considered the male genital variant of lichen sclerosus. Anti-inflammatory drugs are commonly used in BXO. We evaluated effects an innovative formulation ozonated olive oil with vitamin E acetate (OZOILE
Aim: To highlight the ultrasonographic features of prenatal torsion testis in utero (IUTT) at presentation, neonatal management and histological findings postorchiectomy or biopsy. Methods: Seven newborns underwent emergency exploration for IUTT. All patients a sonography real‐time color Doppler ultrasound study scrotum before any surgical procedure. A examination was performed removed specimens. Results: Sonography revealed enlarged, heterogeneous testes. In all cases power did not reveal...
Objective. Primary megaureter (PM) represents 6–10% of all antenatal displaced urinary malformations. Spontaneous resolution PM is a well-known event. This long-term follow-up study evaluated the incidence and rate PM. Some predictive factors were revised, based on morphological classification scintigraphic pattern. Material methods. Sixty neonates with followed. The diagnosis was confirmed by ultrasound examination 99mTc-DTPA diuretic renal scan. All observed patients underwent antibiotic...
Summary The effects of polydeoxyribonucleotide (PDRN), an agonist the A2A adenosine receptors which when activated positively influences sperm activity, were tested in experimental testicular ischaemia/reperfusion injury model. Anaesthetized male Sprague‐Dawley rats subjected to torsion‐induced ischaemia, followed by reperfusion (TI/R). Immediately after detorsion, randomized animals, including SHAM, received intraperitoneal injections of: (i) vehicle (1 mL/kg 0.9% NaCl solution); (ii) PDRN...
Serenoa repens is frequently combined with other natural compounds, such as the carotenoid lycopene and essential trace element Se, to increase its therapeutic activity in benign prostatic hyperplasia. We noted that lycopene-Se-Serenoa combination has greater, enhanced anti-inflammatory activity, which might be of particular interest for hyperplasia treatment. Testosterone administration rats a suitable tool investigating hormone dependent performed comparison experiment between on prostate...
Neuronal apoptosis inhibitory protein (NAIP) and survivin might play an important role in testicular function. We investigated the effect of PDRN, agonist adenosine A2A receptor, on NAIP expression experimental model varicocele. After creation varicocele (28 days), adolescent male Sprague-Dawley rats were randomized to one following treatments lasting 21 days: vehicle, PDRN (8 mg/kg i.p., daily), + 3,7-dimethyl-propargylxanthine (DMPX, a specific A2A-receptor antagonist, 0.1 varicocelectomy,...
Although multiple sclerosis (MS) Intimacy and Sexuality Questionnaire-19 (MSISQ-19) is a widely applied tool, no unique definition of sexual dysfunction (SD) based on its score exists.To explore the impact different MSISQ-19 cut-offs SD prevalence associated risk factors, providing relevant information for application in research clinical settings.After defining according to two 1155 people with MS (pwMS), we evaluated association sociodemographic features, mood status disability via...