A5066304238- Hematopoietic Stem Cell Transplantation
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Neutropenia and Cancer Infections
- Neurological Disorders and Treatments
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral Infections and Outbreaks Research
- Acute Myeloid Leukemia Research
- Neurological Disease Mechanisms and Treatments
- Acute Lymphoblastic Leukemia research
- Adenosine and Purinergic Signaling
- Organ Transplantation Techniques and Outcomes
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Antifungal resistance and susceptibility
- Plant Stress Responses and Tolerance
- Inflammation biomarkers and pathways
- Abdominal Trauma and Injuries
- Lung Cancer Research Studies
- Acute Ischemic Stroke Management
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
Inner Mongolia Agricultural University
2024-2025
Ningbo University
2017-2025
Suzhou Institute of Systems Medicine
2019-2024
Second Affiliated Hospital of Nanchang University
2023-2024
Nanchang University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Nanjing University
2023-2024
Ningbo University Affiliated Hospital
2022-2023
Nanjing Medical University
2020-2022
Xi'an Jiaotong University
2010-2021
Abstract The Ebola crisis occurred in West-Africa highlights the urgency for its clinical treatments. Currently, no Food and Drug Administration (FDA)-approved therapeutics are available. Several FDA-approved drugs, including selective estrogen receptor modulators (SERMs), possess anti-Ebola activities. However, inhibitory mechanisms of these drugs remain elusive. By analyzing structures SERMs their incidental biological activity (cholesterol accumulation), we hypothesized that this induced...
The continuous emergence of SARS-coronavirus 2 (SARS-CoV-2) variants, especially the variants concern (VOC), exacerbated impact coronavirus disease 2019 (COVID-19) pandemic. As key viral entry into host cells, spike (S) protein is major target therapeutic monoclonal antibodies (mAbs) and polyclonal elicited by infection or vaccination. However, mutations S in may change infectivity antigenicity SARS-CoV-2, leading to immune escape from those neutralizing antibodies. To characterize newly...
Summary A chemotherapy‐based mobilization regimen in patients who mobilize poorly, based on etoposide, cytarabine and pegfilgrastim (EAP), has recently been introduced. The aim of this prospective study was to investigate the efficacy safety EAP with poorly mobilizing multiple myeloma (MM) or lymphoma. This single‐arm clinical trial performed at eight public hospitals China registered as a (NCT05510089). inclusion criteria were; (1) diagnosis MM lymphoma, (2) defined ‘poor mobilizer’ (3)...
Abstract Objectives Using strategy of drug repurposing, antiviral agents against influenza A virus (IAV) and newly emerging SARS‐coronavirus 2 (SARS‐CoV‐2, also as 2019‐nCoV) could be quickly screened out. Materials Methods previously reported engineered replication‐competent PR8 strain carrying luciferase reporter gene (IAV‐luc) multiple pseudotyped IAV SARS‐CoV‐2 was used. To specifically evaluate the pH change vesicles containing IAV, we constructed an A549 cell line with endosomal...
Abstract It has been recently reported that CD38 expressed on tumor cells of multiple murine and human origins could be upregulated in response to PD-L1 antibody therapy, which led dysfunction tumor-infiltrating CD8 + T immune due increasing the production adenosine. However, role expressed-CD38 neoplastic formation progression remains elusive. In present study, we aimed delineate molecular biochemical function tumor-associated lung adenocarcinoma progression. Our clinical data showed...
MADS-box transcription factors are important regulators of plant abiotic stress response. Despite the exceptional drought tolerance Agropyron mongolicum, research on governing simulate in this species limited. In study, overexpressing AmMADS47 rice resulted reduced tolerance. Transcriptome sequencing wild-type (WT) and transgenic (OE) at 0 hours (WTD) (OED) 24 osmotic revealed 21,521 differentially expressed genes (DEGs) totally. Further analysis top 20 enriched pathways DEGs between OE WT,...
Inducing early apoptosis in alveolar macrophages is one of the strategies influenza A virus (IAV) evolved to subvert host immunity. Correspondingly, mitochondrial protein nucleotide-binding oligomerization domain-like receptor (NLR)X1 reported interact with polymerase basic 1-frame 2 (PB1-F2) accessory counteract virus-induced apoptosis. Herein, we report that F-box proteins, FBXO6, promotes proteasomal degradation NLRX1, and thus facilitates IAV-induced modulates both macrophage survival...
The evolutionarily conserved F-box family of proteins are well known for their role as the key component SKP1-Cullin1-F-box (SCF) E3 ligase in controlling cell cycle, proliferation and death, carcinogenesis, cancer metastasis. However, thus far, there is only limited investigation on involvement antiviral immunity. In contrast to canonical function FBXO6 associated with SCF complex, we report, this study, that can also potently regulate activation IFN-I signaling during host response viral...
Kashin-Beck disease (KBD) is an endemic and deformable osteoarthrosis. Epidemiological study has revealed that lower Se level the principal environmental factor in pathogenesis of KBD. Selenoprotein P (SEPP1) a special selenoprotein, which primary form vivo . Our aim was to investigate putative association SEPP1 r25191g/a single nucleotide polymorphism (SNP) with KBD risk transcriptional levels whole blood articular cartilage tissue cases controls, respectively. One hundred sixty-seven 166...
Agropyron mongolicum Keng is a diploid perennial grass of triticeae in gramineae. It has strong drought resistance and developed roots that can effectively fix the soil prevent erosion. GDSL lipase or esterases/lipase variety functions, mainly focusing on plant abiotic stress response. In this study, gene from A. mongolicum, designated as AmGDSL1, was successfully cloned isolated. The subcellular localization AmGDSL1 (pCAMBIA1302-AmGDSL1-EGFP) results showed protein only localized cytoplasm....
Methoxychlor (MXC), an organochlorine pesticide, has adverse effects on male reproduction at toxicological doses. Humans and wild animals are exposed to MXC mostly through contaminated dietary intake. Higher concentrations of have been found in human milk, raising the demand for risk assessment offspring after maternal exposure low doses MXC. In this study, pregnant mice (F0) were given intraperitoneal daily evening injections 1 mg/kg/d during their gestational (embryonic day 0.5, E0.5)...
SARS-coronavirus 2 (SARS-CoV-2), pathogen of coronavirus disease 2019 (COVID-19), is constantly evolving to adapt the host and evade antiviral immunity. The newly emerging variants N501Y.V1 (B.1.1.7) N501Y.V2 (B.1.351), first reported in United Kingdom South Africa respectively, raised concerns due unusually rapid global spread. mutations spike (S) protein may contribute spread these variants. Here, with a vesicular stomatitis virus (VSV)-based pseudotype system, we demonstrated that...
Myogenic determination factor 1 (MyoD1) and myogenic 6 (Myf6) genes belong to the differentiation (MyoD) gene family, which play key roles in growth muscle development. The study aimed investigate effects of variants cattle MyoD1 Myf6 on carcass meat traits. We screened single nucleotide polymorphisms (SNPs) both 8 populations, including Simmental, Angus, Hereford, Charolais, Limousin, Qinchuan, Luxi, Jinnan by sequencing. G782A locus was identified exon (MyoD1-BglI) as well T186C...
The apolipoprotein E (APOE) gene is a promising candidate for the diagnosis of hyperlipoproteinaemia and atherosclerosis. Polymorphisms in APOE have been reported to result differential efficacies statin drugs atherosclerotic cardiovascular disease.We classified genotypes 225 patients treated with atorvastatin, analysed relation between serum lipid levels.The baseline levels total cholesterol (TC) low-density lipoprotein (LDL-C) were significantly lower carriers ε3 than ε4 genotypes. TC...
Previous studies have indicated that tumor mitochondrial DNA (mtDNA) mutations are primarily shaped by relaxed negative selection, which is contradictory to the critical roles of mtDNA in tumorigenesis. Therefore, we hypothesized site-specific selection may influence mutations. To test our hypothesis, developed largest collection date and evaluated how natural mutation patterns. Our data demonstrated both positive selections acted on specific positions or functional units mtDNAs, although...
Abstract Background Pure red cell aplasia (PRCA) following allogeneic hematopoietic stem transplantation (allo‐HSCT) with ABO major incompatibility is characterized by transfusion dependent anemia. No standard treatment existed for PRCA allo‐HSCT yet. Study Design and Methods We conducted a retrospective study, reported our experience the use of avatrombopag lower dose rituximab to treat five patients subsequent ABO‐incompatible allo‐HSCT. Results Five cases were identified from 72 who...
Dear Editor, The continuous mutation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within the ongoing epidemic poses a formidable challenge to public health.1, Following emergence Omicron BA.1, rate virus evolution has notably accelerated, giving rise numerous new subvariants.1, 3 Currently, BA.2.86 and its descendant JN.1 are predominant, harboring over 30 additional spike protein mutations compared BA.2 strain.3 These in may enhance transmissibility, potentially...
As the key component of host innate antiviral immunity, type I interferons (IFN-Is) exert multiple effects by inducing hundreds IFN-stimulated genes. However, precise mechanism involved in sensing IFN-I signaling priming is particularly complex and remains incompletely resolved. This research identified F-box protein 11 (FBXO11), a E3-ubiquitin ligase SKP/Cullin/F-box complex, acted as an important regulator process against several RNA/DNA viruses. FBXO11 functioned essential enhancer...