A5100446769- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Enzyme Catalysis and Immobilization
- Cancer-related Molecular Pathways
- Plant Gene Expression Analysis
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Cancer Mechanisms and Therapy
- RNA Research and Splicing
- Cell death mechanisms and regulation
- Electrochemical sensors and biosensors
- Analytical Chemistry and Chromatography
- Plant biochemistry and biosynthesis
- RNA modifications and cancer
- Natural product bioactivities and synthesis
- Photosynthetic Processes and Mechanisms
- Plant tissue culture and regeneration
- Virus-based gene therapy research
- Chemical Synthesis and Analysis
- Plant Molecular Biology Research
- Galectins and Cancer Biology
- Zebrafish Biomedical Research Applications
- DNA and Nucleic Acid Chemistry
- Nicotinic Acetylcholine Receptors Study
Jiangsu Province Hospital
2024
Affiliated Hospital of Nantong University
2015-2024
Nantong University
2015-2024
Weatherford College
2024
Jiangxi Provincial Cancer Hospital
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Binzhou Medical University
2024
Nanjing Medical University
2024
Dongguan University of Technology
2024
Sichuan University
2014-2024
Exosomes are small homogenous membrane vesicles that derive from the exocytosis process of cells and can contain DNA, microRNAs (miRNAs), and/or proteins. Characterization content profile exosomes may reflect state release them, this could be predictive disease. In study, to explore potential biomarkers for melanoma, we isolated serous 30 patients with melanoma healthy individuals using ultracentrifugation method. Five miRNAs were subsequently detected in each sample by quantitative reverse...
Article26 March 2021Open Access Source DataTransparent process Quaking 5 suppresses TGF-β-induced EMT and cell invasion in lung adenocarcinoma Shengjie Wang orcid.org/0000-0003-0320-0377 Soochow University Laboratory of Cancer Molecular Genetics, Medical College University, Suzhou, China Department School Biology Basic Sciences, Medicine, Kangda Nanjing Lianyungang, ChinaThese authors contributed equally to this work Search for more papers by author Xin Tong Chang Li Thoracic Surgery, The...
To convert this underutilized P. citrinopileatus which is well known for its savory taste into the high value-added food ingredients, influence of different sulfur-containing compounds, including l-cysteine (Cys), l-methionine (Met) and thiamine (Thi) on structure, sensory profiles antioxidant activities Maillard Reaction products (MRPs) obtained from was evaluated compared. Sulfur-containing substances significantly enhanced reaction progress MRPs. Cys-MRPs showed strongest fluorescence...
Drug resistance is a critical impediment to efficient therapy of diffuse large B-cell lymphoma (DLBCL) patients. Recent studies have highlighted the association between ferroptosis and drug that has been reported. Fatty acid synthase (FASN) always related poor prognosis. In this study, we investigate impact FASN on in DLBCL explore its potential modulation mechanisms. The clinical correlation mRNA expression was first analyzed confirm role based TCGA database. Next, investigated vitro vivo....
Hepatocellular carcinoma (HCC) is now the major malignant disease with high morbidity and mortality, which seriously endangers human lives health. Alpha fetoprotein (AFP) assay a commonly used serological biomarker for clinical diagnosis of HCC, but it lacks specificity. Analysis its isoform AFP-L3, especially AFP-L3 ratio in total AFP (AFP-L3%), can significantly improve specificity HCC identification. Herein, an electrochemical approach has been first proposed simple, accurate, fast...
Colon cancer, a common type of malignant tumor, seriously endangers human health. However, due to the relatively slow progress in diagnosis and treatment, clinical therapeutic technology colon cancer has not been substantially improved past three decades. The present study was designed investigate effects involved mechanisms schisandrin B cell growth metastasis cancer. C57BL/6 mice received AOM dextran sulfate sodium. Mice treatment groups were gavaged with 3.75-30 mg/kg/day B. Transwell...
Indole alkaloids are one of the largest alkaloid classes, proving valuable structural moiety in pharmaceuticals. Although methods for synthesis indole constantly explored, direct single-step these chemical entities with broad diversity remains a formidable challenge. Herein, we report modular assembly tetrahydrocarboline type from simple building blocks single step while showing compatibility medicinally relevant functionality. In this protocol, 2-alkylated or 3-alkylated indoles,...
AbstractEMMPRIN (extracellular matrix metalloproteinase inducer, CD147) participates in the progression of various malignancies by stimulating synthesis specific metalloproteinases (MMP) from peritumoral fibroblasts. In present study, expression and functional role EMMPRIN was investigated pancreatic neoplasm. QRT-PCR, immunohistochemistry, immunoblot, ELISA analyses were used to analyze expression, localization, release EMMRPIN. Silencing performed using siRNA oligonucleotides, consequences...
In this work, kitchen waste was used as substrate for bio-pesticide production by solid-state fermentation. It assessed to be well suited the growth of Bacillus thuringiensis in experiments. The culture medium contents were optimized an orthogonal test. optimum mixture 55.21% waste, 22.08% wheat bran, 11.04% soybean cake power, grain hulls, and 0.63% mixed ions. conditions, a spore count 5.01 × 1010 CFU/g entomotoxicity 15200 IU/mg obtained after 48 h fermentation, while 2.51 12900 from...
Stomatin‐like protein 2 ( STOML or SLP ‐2) is an oncogenic anti‐apoptotic that upregulated in several types of cancer, including cervical cancer. However, the mechanisms responsible for ‐2 function remain poorly understood. Here, we show si RNA ‐mediated suppression decreases growth human cancer HELA and SIHA cells, increases cisplatin‐induced apoptosis through activation MEK / ERK signaling mitochondrial pathway. The inhibition pathway mediated by increasing Ca 2+ concentration membrane...
Dynamic compaction vibrations (DCV) cause significant environmental impacts. Quantifying key influencing factors is essential for mitigation. This study examines how tamper radius, tamping energy, times, and settlement affect DCV velocity (4000-25000 kN·m energy range) in a miscellaneous fill site. A BP neural network model was developed with these four parameters as inputs vibration output, the influence of each factor on evaluated combination Sobol sensitivity analysis. The results show...
Zanthoxylum armatum DC. is an important economic tree species. Prickle a type of trichome with special morphology, and there are lot prickles on the leaves Z. armatum, which seriously restricts development industry. In this study, cv. Zhuye (ZY) its budding variety 'Rongchangwuci' (WC) (A less prickly mutant variety) at different developmental stages were used as materials, transcriptome sequencing data analyzed. A total 96,931 differentially expressed genes (DEGs) identified among samples,...
Plant-specific TCP transcription factors play an essential role in plant growth and development. They can regulate leaf curvature, flower symmetry the synthesis of secondary metabolites. The flavonoids Ginkgo biloba are one main medicinally bioactivate compounds, which have pharmacological beneficial health effects for humans. In this study, a total 13 genes were identified G. biloba, 5 them belonged to PCF subclades (GbTCP03, GbTCP07, GbTCP05, GbTCP13, GbTCP02) while others CIN (GbTCP01,...
WRKY transcription factor is involved in multiple life activities including plant growth and development as well biotic abiotic responses. We identified 28 genes from transcriptome data of Ginkgo biloba according to conserved domains zinc finger structure selected three genes, which are GbWRKY2, GbWRKY16 , GbWRKY21 for expression pattern analysis. GbWRKY2 was preferentially expressed flowers strongly induced by methyl jasmonate. Here, we cloned the full-length cDNA genomic DNA . The 1,713 bp...