A5051813298- Antimicrobial Peptides and Activities
- Hydrogels: synthesis, properties, applications
- Advanced Polymer Synthesis and Characterization
- Supramolecular Self-Assembly in Materials
- Polymer Surface Interaction Studies
- Inhalation and Respiratory Drug Delivery
- Nanoparticle-Based Drug Delivery
- Chemical Synthesis and Analysis
- Analytical Chemistry and Sensors
- Advanced biosensing and bioanalysis techniques
- Polydiacetylene-based materials and applications
- 3D Printing in Biomedical Research
- Carbon Nanotubes in Composites
- Metal-Organic Frameworks: Synthesis and Applications
- Nanocluster Synthesis and Applications
- Advanced Biosensing Techniques and Applications
- Bone Tissue Engineering Materials
- Polymer composites and self-healing
- Monoclonal and Polyclonal Antibodies Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Graphene and Nanomaterials Applications
- Electrochemical sensors and biosensors
- Glycosylation and Glycoproteins Research
- Antibiotic Resistance in Bacteria
- Fluorine in Organic Chemistry
Centre for Electrochemical Technologies
2015-2025
KUSUDAMA Therapeutics (Spain)
2025
Ayuntamiento de San Sebastián
2016-2021
Boeing (Spain)
2021
Digital Research Alliance of Canada
2020-2021
Centro de Inovação, Empreendedorismo e Tecnologia
2017
University of the Basque Country
2001-2011
Biogipuzkoa Health Research Institute
2011
Instituto de Carboquímica
2009
University of Zurich
2004
A carbon nanotube transistor array was used to detect DNA hybridization. new approach ensure specific adsorption of the nanotubes developed. The polymer poly (methylmethacrylate0.6-co-poly(ethyleneglycol)methacrylate0.15-co-N-succinimidyl methacrylate0.25) synthesized and bonded noncovalently nanotube. Aminated single-strand then attached covalently polymer. After hybridization, statistically significant changes were observed in key parameters. Hybridized traps both electrons holes, possibly...
Despite numerous strategies involving dynamic covalent bonds to produce self-healing hydrogels with similar frequency-dependent stiffness native tissues, it remains challenging use biologically relevant thiol/disulfide exchange confer such properties polymeric networks. Herein, we report a new method based on Metal(I) [Au(I) or Ag(I)] capping protect thiolates from aerial oxidation without preventing thiolate/disulfide exchange. Dynamic were readily prepared by injecting simultaneously...
Introduction: Antibiotic-resistant bacteria kill 25,000 people every year in the EU. Patients subject to recurrent lung infections are most vulnerable severe or even lethal infections. For these patients, pulmonary delivery of antibiotics would be advantageous, since inhalation can achieve higher concentration lungs than iv administration and provide a faster onset action. This allow for doses hence reduce number treatments required. We report here about new nanosystem (M33-NS) obtained by...
Carbon nanotubes, gold nanorods, and silver nanoparticles can be transferred from water to organic solvents back again by using polymeric ionic liquids (PILs) as vehicles (see scheme). The PILs are able trap several nano-objects during their anion-exchange-induced precipitation in water. This reversible process provides a PIL/nano-object composite that is fully redispersible solvents.
One of the approaches for obtaining magnetic resonance imaging (MRI) contrast agents with enhanced relaxivity is to construct macromolecular architectures multiple Gd(III) centres. In some cases, simple grafting chelates into polymeric backbones does not result in an increased relaxivity, due high internal flexibility or a non-rigid attachment chelate macromolecule. Here we describe new method incorporating ions polymer rigid manner by complexing them cross-linker. Thus, acrylic copolymer 4...
Abstract A highly efficient room‐temperature synthetic route to bioconjugable polymeric nanoparticles in the 5–20 nm size range based on single‐chain intramolecular click cycloaddition is described. It illustrated by preparing cross‐linked NPs from poly[MMA‐ co ‐(3‐azidopropyl methacrylate)‐ ‐(3‐trimethylsilyl‐propyn‐1‐yl methacrylate)] terpolymers using a one‐pot procedure and continuous addition technique. For with an excess of azide groups, aminoacid/PMMA were easily obtained performing...
The development of sensors to detect specific weak biological interactions is still today a challenging topic. Characteristics carbohydrate-protein (lectin) include high specificity and low affinity. This work describes the nanostructured impedimetric for detection concanavalin A (Con A) binding immobilized thiolated carbohydrate derivatives (D-mannose or D-glucose) onto screen-printed carbon electrodes (SPCEs) modified with gold nanoparticles. Thiolated D-galactose derivative was employed...
The ability of gold(I) thiolates to self-assemble into polymeric species has been exploited create a pH responsive supramolecular hydrogel based on glutathione.
The intervertebral discs (IVDs) provide unique flexibility to the spine and exceptional shock absorbing properties under impact. inner core of IVD, nucleus pulposus (NP) is responsible for this adaptive behavior. Herein, we evaluate an injectable, self-healing dynamic hydrogel (DH) based on gold(I)-thiolate/disulfide (Au-S/SS) exchange as NP replacement in a motion segment model. For first time, report application covalent hydrogels inside biological tissues. between Au-S species disulfide...
The development of tools for the early diagnosis pancreatic adenocarcinoma is an urgent need in order to increase treatment success rate and reduce patient mortality. Here, we present a modular nanosystem platform integrating soft nanoparticles with targeting peptide active imaging agent diagnostics. Biocompatible single-chain polymer (SCPNs) based on poly(methacrylic acid) were prepared functionalized somatostatin analogue PTR86 as moiety, since receptors are overexpressed cancer. gamma...
Combination of Au-based dynamic hydrogel with 100 nm bioactive glass nanoparticles resulted in the formation an injectable, self-healing and biocompatible nanocomposites osteoinductive properties potential for bone regeneration.
The "pancarcinoma" Tn antigen (αGalNAc-O-Ser/Thr) is a tumor-associated carbohydrate (TACA) overexpressed on the surface of cancer cells and suitable target for anticancer vaccines. However, TACAs commonly show weak immunogenicity, low in vivo stability, poor bioavailability. To address these issues, development physiologically stable TACA synthetic mimetics novel nanocarriers multivalent display are object intense research. Nanomaterials represent scaffolds to multimerize antigens, but...
Poly(N-isopropylacrylamide) (pNIPAM) is a thermoresponsive polymer of great interest in biomedical applications. In this work we combine RAFT polymerization and "click chemistry" for the synthesis well defined single chain pNIPAM nanoparticles below 10 nm size with increasing degree cross-linking. The method consists NIPAM based terpolymers containing alkyne azide functional groups by polymerization. Using procedure polydispersity values 1.2 were obtained. collapsed intramolecular "click"...
We report a new supramolecular dynamic hydrogel, based on concept of reversible aurophilic cross-linkers, mimicking the rheological behaviour healthy synovial fluid under physiological conditions with good cell viability.
Abstract The extracellular matrix protects biofilm cells by reducing diffusion of antimicrobials. Tobramycin is an antibiotic used extensively to treat P. aeruginosa biofilms, but it sequestered in the periphery negative charge and loses its efficacy significantly. Dispersal with enzymes such as DNase I another promising therapy that enhances into biofilm. Here, we combine neutralization tobramycin provided dextran-based single-chain polymer nanoparticles (SCPNs) together break matrix. Our...
Water-dispersible dextran-based single-chain polymer nanoparticles (SCPNs) were prepared in aqueous media and under mild conditions. Radiolabeling of the resulting biocompatible materials allowed study lung deposition aerosols after intratracheal nebulization by means single-photon emission computed tomography (SPECT), demonstrating their potential use as imaging contrast agents.
Abstract A new route to functional polymeric nanoparticles (PNPs) of different chemical nature in the 3 20 nm size range is reported by combining both radical addition fragmentation chain transfer (RAFT) polymerization and “click” chemistry (CC) techniques. RAFT was employed for synthesis well‐defined statistical copolymers with pending –Cl groups along macromolecular chain. After transformation –N treatment sodium azide, an appropriate bifunctional cross‐linker obtain PNPs under CC...
Here we present the concept of metallophilic hydrogels, supramolecular systems in which gelator species are metal-thiolates that self-assemble through attractions. The principle is applied for a small drug, mucolytic agent N-acetyl-L-cysteine (NAC), readily forms hydrogels presence Au(III), Ag(I) and Cu(II) salts. resulting transparent pH induced sol/gel transition. Scanning electron microscopy (SEM) measurements reveal microporous structure form flakes three them. low at these formed (pH <...
Antimicrobial peptides (AMPs) have seen limited clinical use as antimicrobial agents, largely due to issues relating toxicity, short biological half-life, and lack of efficacy against Gram-negative bacteria. However, the development novel AMP-nanomedicines, i.e., AMPs entrapped in nanoparticles, has potential ameliorate these problems. The authors investigated two nanomedicines based on AA139, an AMP currently for treatment multidrug-resistant infections.
Abstract In this communication, polyanionic poly(potassium 3‐sulfopropyl methacrylate) (PSPM) brushes were switched from hydrophilic to hydrophobic by exchange of the counter cations. First, grown means atom transfer radical polymerization (ATRP) thiol monolayers initiating ω ‐mercaptoundecyl bromoisobutyrate and mixed initiator 1‐undecanothiol (blank thiol) attached gold surfaces. The kinetics reaction followed quartz microbalance technique with dissipation (QCM‐D). collapse PSPM in...
In this work we have studied the structure of silver(I) thiolate oligomers that lead to formation argentophilic hydrogels. The results showed two different and clearly distinguishable systems, depending on neutral or acidic character thiol. Neutral systems gave opaque hydrogels, a fibrilar microstructure were very dependent silver : thiol ratio. On other hand, hydrogels transparent, sheet-like not affected by stoichiometry. molecular weight these metallophilic polymers was measured for first...