A5054047770- Probiotics and Fermented Foods
- Digestive system and related health
- Gut microbiota and health
- Protein Hydrolysis and Bioactive Peptides
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Infant Nutrition and Health
- Infant Health and Development
- Pediatric health and respiratory diseases
- Microbial Metabolites in Food Biotechnology
- Biochemical effects in animals
- Consumer Attitudes and Food Labeling
- Helicobacter pylori-related gastroenterology studies
- Diet, Metabolism, and Disease
- Food Allergy and Anaphylaxis Research
- Hormonal Regulation and Hypertension
- Nutrition, Genetics, and Disease
- Eating Disorders and Behaviors
- Muscle metabolism and nutrition
- Respiratory viral infections research
- Nutritional Studies and Diet
- Asthma and respiratory diseases
- Antioxidant Activity and Oxidative Stress
- Celiac Disease Research and Management
- Anesthesia and Sedative Agents
University of Helsinki
2016-2025
Helsinki Art Museum
2017
Institute for Biomedicine
2004-2012
Cambridge University Press
2011
New York University Press
2011
Valio (Finland)
2001-2010
VTT Technical Research Centre of Finland
2008-2009
Tampere University Hospital
2003-2009
Jorvi Hospital
2002-2009
Isfahan University of Medical Sciences
2009
The gut microbiota may contribute to the onset and maintenance of irritable bowel syndrome (IBS). In this study, microbiotas patients suffering from IBS were compared with a control group devoid gastrointestinal (GI) symptoms.Fecal (n = 27) fulfilling Rome II criteria for was age- gender-matched subjects 22). Fecal samples obtained at 3 months intervals. Total bacterial DNA analyzed by 20 quantitative real-time PCR assays covering approximately 300 species.Extensive individual variation...
To unravel the biological function of widely used probiotic bacterium Lactobacillus rhamnosus GG, we compared its 3.0-Mbp genome sequence with similarly sized L. LC705, an adjunct starter culture exhibiting reduced binding to mucus. Both genomes demonstrated high identity and synteny. However, for both strains, genomic islands, 5 in GG 4 punctuated colinearity. A significant number strain-specific genes were predicted these islands (80 72 LC705). The GG-specific included coding bacteriophage...
<i>Lactobacillus rhamnosus</i> GG, ATCC (LGG), has shown antagonism to many bacteria including mutans streptococci. This randomized, double–blind, placebo–controlled intervention study was designed examine whether milk containing LGG an effect on caries and the risk of in children when compared with normal milk. 594 children, 1–6 years old, from 18 municipal day–care centres were included. The received meals coded containers 5 days a week for 7 months. children’s oral health...
ABSTRACT Lactobacillus rhamnosus GG is one of the most thoroughly studied probiotic strains. Its advantages in treatment gastrointestinal disorders are well documented. The aim present study was to demonstrate with colonic biopsies attachment strain human intestinal mucosae and persistence after discontinuation administration. A whey drink fermented fed volunteers for 12 days. Fecal samples were collected before, during, consumption. L. GG-like colonies detected both fecal biopsy samples....
Background: Probiotic bacteria are suggested to reduce symptoms of the atopic eczema/dermatitis syndrome (AEDS) in food‐allergic infants. We aimed investigate whether probiotic have any beneficial effect on AEDS. Methods: Follow‐up severity AEDS by Severity Scoring Atopic Dermatitis (SCORAD) index 230 infants with suspected cow's milk allergy (CMA) receiving, a randomized double‐blinded manner, concomitant elimination diet and skin treatment, Lactobacillus GG (LGG), mixture four strains, or...
Summary Background : Irritable bowel syndrome is a gastrointestinal disorder of unknown aetiology. The effect probiotics in this remains unclear. Aim To investigate whether probiotic mixture containing Lactobacillus rhamnosus GG, L. LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii ssp. shermanii JS effective alleviating irritable symptoms. Methods A total 103 patients fulfilling the Rome I or II criteria took part 6‐month, randomized, double‐blind placebo‐controlled...
Summary Background Irritable bowel syndrome is the most common diagnosis in gastroenterology. Trials suggest certain probiotics to be beneficial. Aim To investigate effects of multispecies probiotic supplementation ( Lactobacillus rhamnosus GG, L. Lc705, Propionibacterium freudenreichii ssp. shermanii JS and Bifidobacterium animalis lactis Bb12) on abdominal symptoms, quality life, intestinal microbiota inflammatory markers irritable syndrome. Methods Eighty‐six patients (Rome II criteria)...
5-Fluorouracil (5-FU)-based chemotherapy is frequently associated with diarrhoea. We compared two 5-FU-based regimens and the effect of Lactobacillus fibre supplementation on treatment tolerability. Patients diagnosed colorectal cancer (n=150) were randomly allocated to receive monthly 5-FU leucovorin bolus injections (the Mayo regimen) or a bimonthly plus continuous infusion simplified de Gramont for 24 weeks as postoperative adjuvant therapy. On basis random allocation, study participants...
Overgrowth of oral yeast is a common problem among the elderly. Probiotic bacteria are known to inhibit growth pathogenic microbes. We tested hypothesis that cheese containing probiotic can reduce prevalence Candida. During this 16-week, randomized, double-blind, placebo-controlled study, 276 elderly people consumed daily 50 g either (n = 136) or control 140). The primary outcome measure was high salivary count (>or= 10(4) cfu/mL) analyzed by Dentocult method. decreased in group from 30% 21%...
Irritable bowel syndrome (IBS) is a common intestinal disorder that includes continuous or recurrent pain and discomfort altered habits. The pathophysiology of IBS incompletely understood, but it may involve an microbiota. aim the present study was to compare composition temporal stability faecal microbiota patients healthy controls by applying culture-based techniques PCR-DGGE analysis. No difference in prevalence mean culturable manners bacteroides, bifidobacteria, spore-forming bacteria,...
The effect of long-term intake two fermented milk products on the development hypertension was compared in young spontaneously hypertensive rats (SHR). contained tripeptides isoleucine-proline-proline (IPP) and valine-proline-proline (VPP), which have been shown to possess angiotensin converting enzyme (ACE) inhibitory activity. Six-week-old SHR were divided into four groups receive orally ad libitum water, skim or (fermented A B; latter is commercially available Japan with trade name...
To study the effects of Lactobacillus rhamnosus GG (LGG) on rheumatoid arthritis (RA).Twenty-one RA patients were randomised to receive 2 capsules LGG or a placebo twice daily in double-blind fashion for 12 months. Arthritis activity was evaluated by clinical examination, HAQ index, and laboratory tests (e.g. ESR, CRP, pro- anti-inflammatory cytokines).There no statistical differences parameters, biochemical variables index between groups over intervention period. The mean number tender...
OBJECTIVE. Live probiotic bacteria and dietary prebiotic oligosaccharides (together termed synbiotics) increasingly are being used in infancy, but evidence of long-term safety is lacking. In a randomized, placebo-controlled, double-blind trial, we studied the effects feeding synbiotics to newborn infants. METHODS. Between November 2000 March 2003, pregnant mothers carrying infants at high risk for allergy were randomly assigned receive mixture 4 species (Lactobacillus rhamnosus GG LC705,...
The present study was carried out to evaluate the blood pressure (BP)-lowering effect and safety aspects of Lactobacillus helveticus LBK-16H fermented milk with high tripeptide doses on hypertensive subjects using 24-h ambulatory measurements (ABPM).In a randomized, double blinded placebo-controlled parallel group study, 94 patients not receiving any drug treatment were given 150 mL twice daily either L. concentration tripeptides (Ile-Pro-Pro 7.5 mg/100 g Val-Pro-Pro 10 g) or control...