A5101615423- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Influenza Virus Research Studies
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Microbial infections and disease research
- Chronic Myeloid Leukemia Treatments
- Immune Response and Inflammation
- Helminth infection and control
- Neurological diseases and metabolism
- Blood disorders and treatments
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Microscopic Colitis
- Agriculture Sustainability and Environmental Impact
- Orthopedic Surgery and Rehabilitation
- T-cell and Retrovirus Studies
- Vector-borne infectious diseases
- Zoonotic diseases and public health
- HIV Research and Treatment
- Ocular and Laser Science Research
- Complement system in diseases
Indiana Cancer Consortium
2016-2024
University of Leeds
2023
Murdoch University
2010-2022
China Animal Health and Epidemiology Center
2018-2021
Ausvet (Australia)
2020
ICF International (United States)
2019
The University of Queensland
2015-2019
University of Pennsylvania
2018
Indiana University
2018
Neurological Surgery
2018
Abstract To understand the mechanisms that mediate germline genetic leukemia predisposition, we studied inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone marrow failure disorder with high risk of myeloid malignancies at an early age. define mechanistic basis clonal hematopoiesis in SDS, investigate somatic mutations acquired by patients SDS followed longitudinally. Here report multiple independent hematopoietic clones arise life, most commonly harboring heterozygous EIF6 or...
Abstract Crovalimab, a novel C5 inhibitor, allows for low‐volume, every‐4‐ week, subcutaneous self‐administration. COMMODORE 1 (NCT04432584) is phase 3, global, randomized trial evaluating crovalimab versus eculizumab in inhibitor‐experienced patients with paroxysmal nocturnal hemoglobinuria (PNH). Adults lactate dehydrogenase ≤1.5 × upper limit of normal and receiving approved doses ≥24 weeks were 1:1 to receive (weight‐based tiered dosing) or continue eculizumab. The original primary study...
To determine the outcome of displaced talar neck fractures at long-term follow-up in terms functional and secondary reconstructive surgery.Retrospective cohort study.Academic level 1 trauma center.Seventy patients with fractures.All were treated open reduction screw fixation.Functional who did not require surgery was assessed using Short Musculoskeletal Function Assessment, Ankle Osteoarthritis Scale score, American Orthopedic Foot Society Ankle-Hindfoot Score. The incidence hindfoot...
A new reassortant influenza (H7N9) virus emerged early 2013 in eastern China. Exposure to H7N9 infected poultry at live bird markets (LBM) was implicated as the main risk factor for human infection. We aimed identify role of LBM biosecurity indicators and movement affected areas.A cross-sectional survey carried out 24 LBMs beginning outbreak all provinces. used univariable analysis factors associated with presence social network spatial quantify connectivity geographic variation...
In China, rabies is a significant public health concern where dogs remain the main reservoir of disease transmission to humans; rabies-related mortality ranks second in world.We compiled all published articles and official documents on mainland China examine challenges needs eliminate country. The Chinese authorities have identified as priority, recognized control key humans required intersectoral collaborations. Efforts been made respond effectively latest re-emergence rabies, which peaked...
African swine fever (ASF) has spread to many countries in Africa, Europe and Asia the past decades. However, potential geographic extent of ASF infection is unknown. Here we combined a modeling framework with assembled contemporary records cases multiple covariates predict risk distribution at global scale. Local spatial variations derived from domestic pigs influenced strongly by livestock factors, while having wild boars mainly associated natural habitat covariates. The maps show that be...
Mixed chimerism (MC), a persistent or increasing number of host cells after allogeneic hematopoietic stem cell transplantation (HSCT), is predictor disease relapse. Donor lymphocyte infusions (DLI) have the potential to enhance graft-versus-malignancy (GVM) effect, reducing risk relapse in patients with MC. Hence, addition utilizing DLI relapsed setting, there motivation pursue pre-emptive for complete remissions HSCT. To assess safety and efficacy DLI, records 86 who received between 2003...
Following the emergence of H7N9 influenza in March 2013, local animal and public health authorities China have been closing live bird markets as a measure to try control epidemic. The role market (LBM) closure on spread N7N9 following LBMs during May 2013 (the first wave) October 2014 second is described this paper. Different provinces implemented actions at different times, intensive media reports started times. Local broiler prices dropped dramatically places with outbreaks more chickens...
Abstract Relapsed/refractory (R/R) Acute Myeloid Leukemia (AML) is a genetically complex and heterogeneous disease with poor prognosis limited treatment options. Thus, there an urgent need to develop therapeutic combinations overcome drug resistance in AML. This open‐label, multicenter, international, phase 1b study evaluated the safety, efficacy, pharmacokinetics of venetoclax combination alvocidib patients R/R Patients were treated escalating doses (400, 600, 800 mg QD, orally, days 1–28)...
Owners of 116 farms, whose flocks had been tested for anthelmintic resistance, were interviewed to determine their use various sheep management and parasite control practices knowledge adoption recommended procedures the prevention resistance. Farmers current recommendations related mainly changing drenches drench groups. Other aspects program including reduction drenching frequency alternative strategies not considered as important by farmers. For most questions a high proportion farmers...
Edwards, John (University of Illinois College Medicine, Chicago, and Albert Einstein Medical Center, Philadelphia, Pa.) Charles Panos . Streptococcal L-forms. V. Acid-soluble nucleotides a group A Streptococcus derived L form. J. Bacteriol. 84: 1202–1208. 1962.—This report deals with comparison the acid-soluble from A, type 12, β-hemolytic streptococcus stable This is first presence cell-wall precursor (uridine diphosphate-muramic acid-peptide) in Cells each organism were obtained during...
Between July 1981 and December 1983, 116 randomly selected sheep farms in the south west of Western Australian were surveyed for resistance to anthelmintics. A faecal worm egg count reduction test was carried out on each farm. Anthelmintics tested thiabendazole (44 mg/kg) levamisole (7.5 given by intra-ruminal injection comparisons made with an untreated group Successful tests 84 68% these had resistant worms present. The prevalence populations H. contortus 18%; Teladorsagia, 41%...
Ataxia of the hind limbs in nine calves was associated with degenerative lesions spinal white matter and neuronal chromatolysis red nucleus, grey various nuclei medulla oblongata cerebellum. The clinical signs were similar to those observed enzootic ataxia deer occurred predominantly Murray Grey breed. pathogenesis appears involve a primary defect central nervous system myelin progressive loss primarily cord.
Limited data exist regarding the use and outcomes of allogeneic HCT in adults 70 years older. We aimed to describe trends this population utilizing reported CIBMTR from 2000-2013 US centers. 1106 recipients ≥70 (89% 70-74, 10% 75-79, <1% ≥80) 103 centers are included. The most common disease indications were AML (54%), MDS/MPN (22%), NHL (10%). 82% had KPS ≥80% 46% HCT-CI ≥3 (HCT-CI capture began 2008). Unrelated donor (URD), HLA-identical sibling (MRD), HLA-mismatched relative, umbilical...
African Swine Fever (ASF) is a contagious disease of domestic and wild pigs caused by the Virus (ASFV). The has spread globally in recent years with serious economic consequences to pork production. This report describes an ASF outbreak that occurred large-scale Chinese commercial pig farm. started 2018 presents spatial temporal infection intensive Pig houses adjacent exit rooms had higher risk (Odds ratio = 14.4, 95%CI: 1.5–140). Introduction presumed have through contaminated vehicle used...