A5080135747- Supramolecular Self-Assembly in Materials
- Pickering emulsions and particle stabilization
- Advanced Polymer Synthesis and Characterization
- Enzyme Catalysis and Immobilization
- Silk-based biomaterials and applications
- Chemical Synthesis and Analysis
- Advanced Biosensing Techniques and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Microfluidic and Capillary Electrophoresis Applications
- Surfactants and Colloidal Systems
- Enzyme Production and Characterization
- Advanced Sensor and Energy Harvesting Materials
- Phytochemical compounds biological activities
- Advanced Materials and Mechanics
- Cancer therapeutics and mechanisms
- biodegradable polymer synthesis and properties
- Pineapple and bromelain studies
- Click Chemistry and Applications
- Dendrimers and Hyperbranched Polymers
- Antimicrobial Peptides and Activities
- Diatoms and Algae Research
- Carbohydrate Chemistry and Synthesis
- Conducting polymers and applications
Pontificia Universidad Católica de Valparaíso
2021-2024
22q11 Ireland
2019-2021
Royal College of Surgeons in Ireland
2016-2019
Durham University
2010-2013
Porous materials are currently of great scientific as well technological interest. A strategy that is increasingly employed to prepare highly porous and defined macroporous polymers emulsion templating, whereby the droplets a high internal phase used create pores in solid material by curing or polymerization continuous phase. This Feature Article covers recent work this area, focusing on: preparation such from new precursors via novel approaches; chemical modification existing materials;...
Highly porous polymeric materials are prepared by thiol–ene and thiol–yne mediated network formation using high internal phase emulsion templates. The efficiency of is between 80 90% for all while the display enhanced strength toughness due to their higher degree crosslinking.
Glycidyl methacrylate (GMA) emulsion-templated porous polymers (polyHIPEs) were prepared by thermal and photopolymerisation derivatised with morpholine, tris(2-aminoethylamine) a bisamino-PEG homobifunctional molecule. The extent of the functionalization reactions was investigated range qualitative quantitative techniques (FTIR, CHN analysis, titration, XPS, HR-MAS NMR spectroscopy, ninhydrin assay Fmoc number determination) found to be excellent for small molecule amines (up 89% conversion)...
Printing of novel linear polypeptide hydrogel bioinks and stabilisation structures by post-printing UV-triggered crosslinking through catalyst free thiol–yne click chemistry cysteine propiolated 4-arm PEG.
Electrospinning is considered a relatively simple and versatile technique to form high porosity porous scaffolds with micron nanoscale fibers for biomedical applications. Here, electrospinning of unsaturated aliphatic polyglobalide (PGl) into well-defined an average diameter 9 μm demonstrated. Addition dithiol cross-linker photoinitiator the polymer solution enabled UV-triggered intracross-linking during spinning process. The in situ cross-linking resulted amorphous material able swell up...
Statistical copolypeptides comprising lysine and tyrosine with unprecedented ion-induced gelation behavior are reported. Copolypeptides obtained by one-step
Controlling molecular weight, crosslink density and chirality in covalent polypeptide hydrogels allows the independent tuning of rheological, water uptake, degradation antimicrobial properties.
Crosslinking of tryptophan (Trp) containing copolypeptides with varying ratios benzyl-l-glutamate (BLG) and Nα-(carbobenzyloxy)-l-lysine (Z-Lys) is achieved by the selective reaction hexamethylene-bis-TAD (bisTAD). Conversion resulting organogels into biocompatible hydrogels full BLG or Z-Lys deprotection demonstrated. Moreover, diffusion controlled allows design macroscopic hybrid organohydrogels comprising hydrophilic as well hydrophobic regions at a desired ratio position. FTIR SEM...
Abstract Owing to their wide range of inherent functionality, hydrolytic stability, biodegradability, and low toxicity, polypeptide‐based materials have been increasingly exploited for controlled drug release applications. More recently, the incorporation poly(α‐peptoid)s such as poly(sarcosine) into has investigated owing potential naturally derived “stealth polymers.” Here synthesis novel amphiphilic polypept(o)ide nanoparticles is described utilizing silica templates a macroinitiator...
Crosslinking of an unsaturated aliphatic polyester poly(globalide) (PGl) by bistriazolinediones (bisTADs) is reported. First, a monofunctional model compound, phenyl–TAD (PTAD), was tested for PGl functionalisation. 1H-NMR showed that PTAD–ene reaction highly efficient with conversions up to 97%. Subsequently, hexamethylene bisTAD (HM–bisTAD) and methylene diphenyl (MDP–bisTAD) were used crosslink electrospun fibres via one- two-step approaches. In the one-step approach, collected in...
Polymerisation of α-amino acid N-carboxyanhydrides (NCAs) is one the most common techniques to prepare synthetic polypeptides. Of special interest are NCAs derived from acids, L-aspartic and L-glutamic acid, since investigations have been focused on their use synthesise multiblock copolypeptides or hybrid polypeptide-polymers design excipients suitable for delivery bioactive compounds. This perspective highlights advantages using over other natural acids in that pendant carboxyl group serves...
Chemical amination of the enzyme was demonstrated to favor immobilization onto polydopamine (PDA)-coated magnetic nanoparticles (MNPs) for first time, best author's knowledge. MNPs prepared via hydrothermal synthesis were coated with PDA naringinase. X-ray diffraction, transmission electron microscopy, photoelectron spectroscopy, and Fourier-transform infrared spectroscopy showed that composed mainly Fe