A5080885767- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- Luminescence and Fluorescent Materials
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Adenosine and Purinergic Signaling
- Pregnancy and preeclampsia studies
- Iron Metabolism and Disorders
- Hydrogels: synthesis, properties, applications
- Dendrimers and Hyperbranched Polymers
- Advanced Photocatalysis Techniques
- Adsorption and biosorption for pollutant removal
- Extracellular vesicles in disease
- RNA modifications and cancer
- Proteoglycans and glycosaminoglycans research
- Electrospun Nanofibers in Biomedical Applications
- Cancer Treatment and Pharmacology
- Cancer Research and Treatments
Qingdao University
2016-2025
American Pharmacists Association
2025
Wuhan Institute of Technology
2018-2022
Sichuan University
2022
Henan Provincial People's Hospital
2021
Zhengzhou University
2021
Xinjiang Medical University
2013-2020
Qingdao Center of Resource Chemistry and New Materials
2020
Shenyang University of Technology
2011-2019
Princeton University
2014
Two-dimensional (2D), layered transition metal dichalcogenides (TMDCs) can grow in two different growth directions, that is, horizontal and vertical. In the growth, 2D TMDC layers planar direction with their basal planes parallel to substrates. vertical standing upright on substrates exposing edge sites rather than planes. The distinct morphologies present unique materials properties suitable for specific applications, such as TMDCs optoelectronics electrochemical reactions. Precise control...
Abstract Photodynamic therapy (PDT) is an emerging technology for tumor treatment in which photosensitizer (PS)-mediated light irradiation reduces oxygen, producing high levels of reactive oxygen species (ROS) that can cause vascular injury and effectively kill cells. However, the naturally hypoxic microenvironment main obstacle hinders photodynamic response vivo prevents its extensive application to treatment. Moreover, PDT-mediated consumption further increases hypoxia, potentially causing...
Abstract Background Temozolomide (TMZ) resistance limits its application in glioma. Exosome can carry circular RNAs (circRNAs) to regulate drug via sponging microRNAs (miRNAs). miRNAs control mRNA expression by the interaction with 3’UTR and methylation. Nanog homeobox (NANOG) is an important biomarker for TMZ resistance. Hitherto, it unknown about role of exosomal hsa_circ_0072083 (circ_0072083) glioma, whether associated NANOG regulating miRNA sponge Methods TMZ-resistant ( n = 36)...
Phototheranostics, which combines deep tissue imaging and phototherapy [photodynamic therapy (PDT) and/or photothermal (PTT)] via light irradiation, is a promising strategy to treat tumors. Near-infrared (NIR) cyanine dyes are researched as potential phototheranostics reagents for their excellent photophysical properties. However, the low singlet oxygen generation efficiency of often leads inadequate therapeutic efficacy Herein, we modified an indocyanine green derivative Cy7 with heavy atom...
Photodynamic therapy (PDT) is a promising strategy in cancer treatment that utilizes photosensitizers (PSs) to produce reactive oxygen species (ROS) and eliminate cells under specific wavelength light irradiation. However, special tumor environments, such as those with overexpression of glutathione (GSH), which will consume PDT-mediated ROS, well hypoxia the microenvironment (TME) could lead ineffective treatment. Moreover, PDT highly light-dependent therefore can be hindered deep where...
Microfluidics-mediated NDDS show uniform morphology, size and distribution, reduced batch-to-batch variations controllable drug delivering capacity.
Abstract Background In the last decade, graphene oxide-based nanomaterials, such as oxide (GO) and reduced (rGO), have attracted more attention in field of biomedicine. Due to versatile surface functionalization, ultra-high area, excellent biocompatibility which hold better promise for potential applications than among other nanomaterials biomedical fields including drug/gene delivery, biomolecules detection, tissue engineering, especially cancer treatment. Results Here, we review recent...
Osteoarthritis (OA) is a common degenerative joint disease that can lead to disability. Blocking the complex malignant feedback loop system dominated by oxidative stress and pro-inflammatory factors key treating OA. Here, we develop multifunctional composite thermo-sensitive hydrogel (HPP@Cu gel), which utilized Poloxamer 407 (P407) hyaluronic acid (HA) mixture as gel matrix, then physically mixed with copper nanodots (Cu NDs) platelet-rich plasma (PRP). Cu NDs novel nano-scavenger of...
Patients treated with Pt-based anticancer drugs (Pt
Enantioselective organocatalytic domino reactions of <italic>in situ</italic> generated <italic>ortho</italic>-quinone methides with malononitrile and β-functionalized ketones have been developed. This strategy could generate various chiral chromenes in high yields stereoselectivities.
We demonstrate a one-step, facile chemical synthesis of heterostructures based on two-dimensional (2D) transition metal dichalcogenides (TMDCs) with vertically aligned 2D layers. Specifically, by using vapor transport method, we synthesize molybdenum (Mo)/tungsten (W)-based disulfide and diselenide heterostructures, such as MoS2/WS2 MoSe2/WSe2. Detailed structural characterizations reveal that the layers two different TMDCs are standing/aligned exposing edge sites The TMDC heterostructure...