A5002992643- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Extracellular vesicles in disease
- Cancer Treatment and Pharmacology
- Pain Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Advanced Nanomaterials in Catalysis
- Anesthesia and Pain Management
- Adenosine and Purinergic Signaling
- Anesthesia and Neurotoxicity Research
- IL-33, ST2, and ILC Pathways
- Ferroptosis and cancer prognosis
- Spine and Intervertebral Disc Pathology
- Cancer, Stress, Anesthesia, and Immune Response
- Myofascial pain diagnosis and treatment
- Pediatric Pain Management Techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Neuroscience and Neuropharmacology Research
- DNA and Nucleic Acid Chemistry
- Musculoskeletal pain and rehabilitation
- Dendrimers and Hyperbranched Polymers
- Immune cells in cancer
Sichuan University
2014-2024
Qingdao University
2021-2024
Affiliated Hospital of Qingdao University
2024
Central South University
2006-2022
Xiangya Hospital Central South University
2010-2022
Qingdao Center of Resource Chemistry and New Materials
2021
Chengdu University
2017-2019
<sc>d</sc>-(KLAKLAK)<sub>2</sub>-and Cy5-modified tetrahedral DNA nanostructures for imaging-guided mitochondria-targeted drug delivery
Patients treated with Pt-based anticancer drugs (Pt
Epirubicin (EPI) alone can trigger mildly protective autophagy in residual tumor cells, resulting an immunosuppressive microenvironment. This accelerates the recurrence of tumors and leads to antiprogrammed death ligand 1 (anti-PD-1)/PD-L1 therapy resistance, posing a significant clinical challenge immunotherapy. The combination checkpoint inhibitors targeting PD-1/PD-L1 pathway amplifying presents innovative approach treatment, which prevent immune escape enhance therapeutic recognition....
Immune and inflammatory responses occurring in the spinal cord play a pivotal role progression of radicular pain caused by intervertebral disk herniation. Interleukin-33 (IL-33) orchestrates wide range autoimmune disorders nervous system. Thus, purpose this study is to investigate expression IL-33 its receptor ST2 dorsal elucidate whether inhibition significantly attenuates pain-related behaviors rat models noncompressive lumbar disc Lentiviral vectors encoding short hairpin RNAs that target...
Improving the deep penetration of nanoparticles and realizing combination chemotherapy immunotherapy have become a promising strategy for cancer treatment.
Abstract Autophagy enables the maintenance of nutrient recycling and metabolic homeostasis through a multistep lysosomal degradation pathway, it has been demonstrated that autophagy can act as tumor suppressor or promoter, depending on microenvironment (TME). The dual role in tumorigenesis results two opposing therapeutic strategies, namely, inhibition versus promotion. However, due to protective mechanisms cells absence specific strategies for regulation, modulation become major...
Abstract Chemotherapeutics can induce immunogenic cell death (ICD) by triggering autophagy and mediate antitumor immunotherapy. However, using chemotherapeutics alone only cause mild cell‐protective be incapable of inducing sufficient ICD efficacy. The participation inducer is competent to enhance autophagy, so the level promoted effect immunotherapy highly increased. Herein, tailor‐made cascade amplification polymeric nanoparticles STF@AHPPE are constructed tumor Arginine (Arg),...
Abstract Deep penetration and downregulation of heat shock protein (HSP) expression in multimodal synergistic therapy are promising approaches for curing cancer clinical trials. However, free small‐molecule drugs most drug vehicles have a low delivery efficiency deep into the tumor owing to poor hypoxic conditions at site. In this study, objective is use reactive oxygen species (ROS)‐responsive supramolecular gels co‐loaded with photosensitizer Zn(II) phthalocyanine tetrasulfonic acid (ZnPCS...
Cardiac fibrosis is a pathological process characterized by excess extracellular matrix (ECM) deposition and plays critical role in nearly all types of heart disease. The mechanism cardiac still unclear no effective medication treatment fibrosis. Research showed that mesenchymal stem cell (MSC) derived exosomes may play effect human amniotic fluid MSC (hAFMSC)-derived (hAFMSCExos) on has remained unclear.The hAFMSCExos were extracted using sequential centrifugation approach. effects...
Combination therapy is extensively developed for cancer treatment in recent years due to its high efficiency. Herein, we constructed a nanocomposite based on gold nanorods (GNRs) and drug-loaded tetrahedral DNA nanostructures (TDN) chemo-photothermal combinational therapy. Anti-tumor drug doxorubicin (DOX) was loaded via the insertion within GC base pairs of TDN. The aptamer AS1411 attached apex TDN (ATDN) target tumor cells. DOX-loaded tetrahedron (ATDN-DOX) compressed by GNRs coated with...
Chemotherapy (CT) can convert tumor cells into "tumor vaccines" through immunogenic cell death (ICD). However, the antitumor immunity elicited by CT-induced vaccines is weak. Therefore, developing efficient a challenge. Herein, we report novel strategy to induce CT with strong effect. Targeted tetrahedral DNA nanostructures modified AS1411 and immune adjuvant CpG (abbreviation: ACT) were used achieve multi-drug co-loading system of DOX methylene blue (MB, photosensitizer for photodynamic...
We report a supramolecular hierarchical nanocomposite for combination photodynamic, photothermal, and chemotherapy.
Our study demonstrated a biocompatible peptide/DNA composite nanoplatform for combinational cancer therapy via the targeted delivery of therapeutic agents and efficient lysosomal escape.
Tumors have become the biggest obstacle to human health, and there are various treatment methods at present. Photothermal therapy (PTT) is usually ineffective does not inhibit tumor progression due inability of lasers penetrate deeply. Therefore, most existing studies chose a 1064 nm laser with stronger penetrating power; meanwhile, shown that inclusion harmful free radicals can significantly improve antitumor efficacy. Herein, TiO nanosheets (NSs) were creatively prepared encapsulated an...