A5101955801- Hearing, Cochlea, Tinnitus, Genetics
- Bone fractures and treatments
- Connexins and lens biology
- Hip and Femur Fractures
- Fluid Dynamics and Heat Transfer
- Erythrocyte Function and Pathophysiology
- Total Knee Arthroplasty Outcomes
- Ion Channels and Receptors
- Orthopaedic implants and arthroplasty
- Animal Vocal Communication and Behavior
- Marine animal studies overview
- Neonatal Health and Biochemistry
- Sports injuries and prevention
- Fluid Dynamics and Thin Films
- Fluid Dynamics and Mixing
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Foot and Ankle Surgery
- Advanced Glycation End Products research
- Lipid Membrane Structure and Behavior
- Enhanced Oil Recovery Techniques
- Lattice Boltzmann Simulation Studies
- Heme Oxygenase-1 and Carbon Monoxide
Shanghai Sixth People's Hospital
2013-2025
Shanghai Jiao Tong University
2012-2025
ShanghaiTech University
2019
Super-resolution fluorescence imaging reveals a previously unknown novel structure of spectrin in inner ear hair cells.
BACKGROUND The purpose of our study is to introduce a new Three-Column Classification for tibial plateau fractures and evaluate its reproducibility reliability. METHODS From December 2004 2006, 278 consecutive patients with were treated operatively at the Department Orthopedics Trauma III in Shanghai Sixth People's Hospital. Computed tomography (CT) three-dimensional reconstruction preformed each patient before open reduction internal fixation. approaches instructed by Classification. To...
Abstract Zebrafish ( Danio rerio ) is an important model organism in hearing research. However, data on the sensitivity of zebrafish vary across different reports. In present study, was examined by analysing auditory evoked potentials (AEPs) over a range total lengths (TLs) from 12 to 46 mm. Morphological changes hair cells (HCs) saccule (the main end organ) and their synapses with primary neurons were investigated. The AEPs detected up much higher frequency limit (12 kHz) than previously...
Bilirubin, an endogenous metabolite with many significant physiological roles, particularly anti-inflammatory properties, shows great promise as a treatment for inflammatory diseases. However, the binding targets and downstream signaling mechanisms of bilirubin remain unclear. Here, by using quantitative phosphorylation proteomics several powerful chemical biology techniques such Cellular Thermal Shift Assay (CETSA), molecular docking, MicroScale Thermophoresis (MST), it is identified...
Phosphatidylserine is translocated to the inner leaflet of phospholipid bilayer membrane by flippase function type IV P-tape ATPase (P4-ATPase), which critical maintain cellular stability and homeostasis. Transmembrane protein 30A (TMEM30A) β-subunit P4-ATPase. Loss P4-ATPase causes sensorineural hearing loss visual dysfunction in human. However, TMEM30A auditory system unclear.P4-ATPase subtype expression cochlea was detected immunofluorescence staining quantitative real-time polymerase...
In this study, we investigated the role of MAP kinase phosphatase-1 (MKP-1) and rosiglitazone (RSG) in glucocorticoid resistance sensitivity, respectively, using a guinea pig model lipopolysaccharide- (LPS-) induced sudden sensorineural hearing loss (SSHL). The pigs were divided into control, LPS, LPS+dexamethasone (DEX), LPS+RSG, LPS+DEX+RSG groups. Their was screened by auditory brainstem response measurement. Immunofluorescence staining used to identify location MKP-1 inner ear....
Noise-induced hearing loss (NIHL) is characterized by cellular damage to the inner ear, which exacerbated inflammation. High-mobility group box 1 (HMGB1), a representative damage-associated molecular pattern (DAMP), acts as mediator of inflammation or an intercellular messenger according its localization. Blocking regulating HMGB1 offers attractive approach in ameliorating NIHL. However, precise therapeutic intervention must be based on deeper understanding dynamic distribution and function...