A5001789349- Plant Reproductive Biology
- Plant Molecular Biology Research
- Polysaccharides and Plant Cell Walls
- Ubiquitin and proteasome pathways
- Ion Channels and Receptors
- CAR-T cell therapy research
- Signaling Pathways in Disease
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Photosynthetic Processes and Mechanisms
- Plant Stress Responses and Tolerance
- Cardiac Fibrosis and Remodeling
Harvard University
2024
University of Massachusetts Amherst
2020-2023
University of Massachusetts Boston
2021
University of Massachusetts System
2018
Highlights•FER is necessary to maintain cell-wall integrity during the salt-stress response•Pectin cross-linking protects cell walls against damage induced by salinity•The extracellular domain of FER interacts directly with pectin•FER induces cell-specific [Ca2+] transients that integritySummaryCells despite changes in their mechanical properties elicited growth and environmental stress. How cells sense physical state compensate for poorly understood, particularly plants. Here we report...
Pathological deposition and crosslinking of collagen type I by activated myofibroblasts drives progressive tissue fibrosis. Therapies that inhibit synthesis have potential as anti-fibrotic agents. We identify the chaperone cyclophilin B a major cellular target natural product sanglifehrin A (SfA) using photo-affinity labeling chemical proteomics. Mechanistically, SfA inhibits induces secretion from endoplasmic reticulum (ER) prevents TGF-β1–activated synthesizing secreting in vitro, without...