Objective: To assess the incidence and risk factors of hyperuricemia among Chinese adults in 2017–2018. Methods: A total 2,015,847 (mean age 41.2 ± 12.7, 53.1% men) with serum uric acid concentrations assayed on at least two separate days routine health examinations during 2017–2018 were analyzed. Hyperuricemia was defined as fasting urate concentration >420 μmol/L men >360 women. The overall sex-specific rate stratified according to age, urban population size, geographical region,...

Abstract Background Coronary heart disease (CHD) and type 2 diabetes (T2D) are two complex diseases with interrelationships. However, the genetic architecture of is often studied independently by individual single-nucleotide polymorphism (SNP) approach. Here, we presented a genotypic-phenotypic framework for deciphering underlying patterns CHD T2D. Method A data-driven SNP-set approach was performed in genome-wide association study consisting subpopulations different T2D (comorbidity,...

Background/Objectives: Genes and environments were transmitted across generations. Parents' genetics influence the of their offspring; these two modes inheritance can produce a genetic nurture effect, also known as indirect effects. Such effects may partly account for estimated variance in T2D. However, well-established specific risk factors about effect T2D are not fully understood. This study aimed to investigate on type 2 diabetes reveal potential underlying mechanism using publicly...

Sleep irregularity is increasingly recognized as a modifiable factor for cardiovascular health. This study aims to investigate relationships between short- and long-term sleep with blood pressure (BP) dynamics among older adults. We used data from prospective cohort involving community-dwelling adults based on mobile health (mHealth) app 2018 2022. Short-term exposure was defined one week. Cumulative irregularity, calculated the area under curve over 12 months, regarded exposure. Outcomes...

Artery stiffness is an independent marker for atherosclerotic cardiovascular diseases. However, whether the brachial-ankle pulse wave velocity (ba-PWV) related to new carotid plaque formation unresolved. This study aimed investigate association between baseline ba-PWV and in a Chinese community-based population without plaques at baseline. consisted of total 738 participants from atherosclerosis cohort Beijing, China. After mean 2.3-year follow-up, incidence were 21.2% 36.5% groups with <...

The paucity of evidence on longitudinal and consecutive recordings physical activity (PA) blood pressure (BP) under real-life conditions their relationships is a vital research gap that needs to be addressed.

Central blood pressure level is not always consistent with peripheral level, and especially their joint effect on incident hypertension well established. A total of 1607 non-hypertensive subjects from an atherosclerosis cohort in Beijing, China were included. systolic (cSBP) was obtained using Omron HEM-9000AI machine (pSBP) measured HEM-7117 electronic sphygmomanometer, separately. Hypertension defined as BP ≥ 140/90 mmHg or self-reported taking any antihypertension drugs at the follow-up...

Early- and late-onset narcolepsy constitutes two distinct diagnostic subgroups. However, it is not clear whether symptomology genetic risk factors differ between early- narcoleptics. This study compared clinical data single-nucleotide polymorphisms (SNPs) patients in a large cohort of 899 Han Chinese patients. Blood, cerebrospinal fluid, were prospectively collected from patients, genotyped for 40 previously reported risk-conferring SNPs. Genetic scores (GRSs), associations five different...

Accumulating evidence suggests a relationship between type 2 diabetes mellitus and sleep problems. A comprehensive study is needed to decipher whether shared polygenic risk variants exist diabetic traits traits.We integrated summary statistics from different genome-wide association studies investigated overlap in single-nucleotide polymorphisms (SNPs) associated with diabetes-related (type diabetes, fasting glucose, insulin, glycated hemoglobin) (insomnia symptoms, duration, chronotype)...

Background: Genome-wide association studies (GWASs) have identified a large number of single-nucleotide polymorphisms (SNPs) associated with narcolepsy. However, the sum impact these SNPs on defining genomic risk narcolepsy remains unknown. In present study, we investigated associations between genetic scores (GRSs) and along their predictive power Methods: A case-control study consisting 903 patients 1,981 healthy control subjects was performed. Thirty-two previously reported to confer...

Atrial fibrillation (AF) is the most common cardiac arrhythmia, with uncovered genetic etiology and pathogenesis. We aimed to screen out AF susceptibility genes potential pathogenesis significance in Chinese population.Differentially expressed (DEGs) were screened by Limma package three GEO data sets of atrial tissue. AF-related identified combination DEGs public GWAS genes. Potential drug target selected using DrugBank, STITCH TCMSP databases. Pathway enrichment analyses performed databases...

Genome-wide association studies (GWAS) have identified several common variants associated with polycystic ovary syndrome (PCOS). However, the etiology behind PCOS remains incomplete. Available evidence suggests a potential genetic correlation between and type 2 diabetes (T2D). The publicly available data may provide an opportunity to enhance understanding of etiology. Here, we quantified polygenic overlap T2D using summary statistics then novel this phenotypic association. A bivariate causal...

Abstract Background and objective Excessive daytime sleepiness (EDS) has been far back reported as the most disabling symptom in pediatric narcoleptic patients. However, there is a lack of studies to examine circadian rhythms EDS population. Therefore, we aim investigate rhythm narcolepsy Methods We identified 50 patients (36 males 14 females, mean age 13.68 ± 2.75 years). Data were collected through interviews relevant questionnaires (children depression inventory [CDI] quality life...

Coronary artery disease (CAD) is a common comorbidity of type 2 diabetes mellitus (T2DM). However, the pathophysiology connecting these two phenotypes remains to be further understood. Combined analysis in multi-ethnic populations can help contribute deepening our understanding biological mechanisms caused by shared genetic loci. We applied correlation and then performed conditional joint association analyses Chinese, Japanese, European identify variants jointly associated with CAD T2DM....

Recent genome-wide association studies have identified an important role of T-cell receptor α (TRA) gene in the development narcolepsy type 1. However, TRA haplotype polymorphisms symptomatic diversity remains unclear. This study aimed to investigate whether can influence narcolepsy.Totally, 903 patients with 1 were included study. Patients divided into different groups according their symptoms. First, 13 genotyped single nucleotide assessed for symptoms narcolepsy. We used Chi-square test...

Aims:To investigate the interactions among narcolepsy-associated genes and reveal pathways these involved through bioinformatics analyses. Methods:The study was performed with following steps: 1) Selected previously discovered narcolepsy risk literature review, 2) pathway enrichment analysis, construction of gene-gene protein-protein interaction (PPI) networks for narcolepsy.Results: GO analysis revealed positive regulation interferon-gamma production as most enriched terms in biological...

Background Post-vaccination safety is a major public health concern. The genetic predisposition on immune response has not been clearly identified. Clarifying whether individual plays role adverse events (AEs) critical for the prevention of AEs.Methods From July 2019 to June 2020, we performed case-control study among children aged 3–24 months in seven Chinese provinces. Each child received combination vaccination against diphtheria, tetanus, acellular pertussis, and Haemophilus influenzae...

Objective Hyperlipidemia is traditionally considered a risk factor for diabetes. The effect of low-density lipoprotein cholesterol (LDL-C) counterintuitive to We sought investigate the relationship between LDL-C and diabetes better lipid management. Methods tested shape association created polygenic scores generated linear Mendelian randomization (MR) estimates evaluated nonlinearity in observational genetic Results Traditional analysis suggested complex non-linear while nonlinear MR...

The aggregation and interaction of metabolic risk factors leads to highly heterogeneous pathogeneses, manifestations, outcomes, hindering stratification targeted management. To deconstruct the heterogeneity, we used baseline data from phase II Fangshan Family-Based Ischemic Stroke Study (FISSIC), a total 4632 participants were included. A 732 individuals who did not have any component syndrome (MetS) set as reference group, while 3900 with abnormalities clustered into subtypes using...

We aim to compare the relative heritability contributed by variants of behavior-related environmental phenotypes and elucidate role these factors in conundrum "missing heritability" type 2 diabetes. Methods: used Linkage-Disequilibrium Adjusted Kinships (LDAK) LDAK-Thin models calculate each variant for phenotype. Biological analysis was carried out phenotype whose made a significant contribution. Potential hub genes were prioritized based on topological parameters protein-protein...

Background: Research on the etiology of coronary heart disease (CHD) has been booming over past decades, but it not effective in research CHD. There is an urgent need to expand CHD focus beyond a single molecular event towards comorbidity status.Methods: Reverse GWAS, data-driven analytical approach method, was used cluster within participants from case‒control study. Each named according its baseline characteristics, and 2-year risk onset assessed. We then fuzzy nonnegative matrix...

<sec> <title>BACKGROUND</title> The paucity of evidence on longitudinal and consecutive recordings physical activity (PA) blood pressure (BP) under real-life conditions their relationships is a vital research gap that needs to be addressed. </sec> <title>OBJECTIVE</title> This study aims (1) investigate the short-term relationship between device-measured step volume BP; (2) explore joint effects variability (3) examine whether association patterns PA BP varied across sex, hypertension...