A5054090110- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- EEG and Brain-Computer Interfaces
- Receptor Mechanisms and Signaling
- Neural Networks and Applications
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Sleep and Wakefulness Research
- Ion channel regulation and function
- stochastic dynamics and bifurcation
- Neural and Behavioral Psychology Studies
- Vestibular and auditory disorders
- Neurological disorders and treatments
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Visual perception and processing mechanisms
- Neuropeptides and Animal Physiology
- Transcranial Magnetic Stimulation Studies
- Retinal Development and Disorders
- Pharmacological Receptor Mechanisms and Effects
- Advanced Memory and Neural Computing
- Advanced Fluorescence Microscopy Techniques
Tamagawa University
2015-2025
Ogori Daiichi General Hospital
2025
Tokyo University of Science
2025
Tokushima University
2024-2025
Tokyo Medical and Dental University
2019-2024
Nagoya University Hospital
2024
Institute of Science Tokyo
2024
Shanghai Institute for Science of Science
2024
Tokushima University Hospital
2024
Japan Science and Technology Agency
2002-2019
Recent evidence has suggested that theta-frequency (4-7 Hz) oscillations around the human anterior cingulate cortex (ACC) and frontal cortex--that is, midline theta (Fm theta) oscillations--may be involved in attentional processes brain. However, little is known about physiological basis of Fm because invasive study allowed only limited cases. In present study, we developed a monkey model for located generators waves using electrodes implanted various cortical areas. Monkeys were engaged...
It is widely accepted that dorsal striatum neurons participate in either the direct pathway (expressing dopamine D1 receptors) or indirect D2 receptors), controlling voluntary movements an antagonistically balancing manner. The D1- and D2-expressing are activated inactivated, respectively, by released from substantia nigra encoding reward expectation. However, little known about functional representation of motor information its modulation individual striatal constituting two pathways. In...
Simultaneous recordings with multi-channel electrodes are widely used for studying how multiple neurons recruited information processing. The recorded signals contain the spike events of a number adjacent or distant and must be sorted correctly into trains individual neurons. Several mathematical methods have been proposed sorting but process is difficult in practice, as extracellularly corrupted by biological noise. Moreover, often time-consuming, it usually requires corrections human...
The lateral habenula (LHb) regulates the activity of monoaminergic neurons in brainstem. This area has recently attracted a surge interest psychiatry because studies have reported pathological activation patients with major depression and animal models. LHb plays significant role pathophysiology depression; however, how habenular are activated to cause various symptoms, such as reduced motivation sleep disturbance, remain unclear. We hypothesized that dysfunctional astrocytes may...
The architectonic subdivisions of the brain are believed to be functional modules, each processing parts global functions. Previously, we showed that neurons in different regions operate firing regimes monkeys. It is possible reflect differences underlying information processing, and consequently homologous across animal species might similar. We analyzed neuronal spike trains recorded from behaving mice, rats, cats, regularity differed systematically, with one being greater than similar...
Functional clustering of neurons is frequently observed in the motor cortex. However, it unknown if, when, and how fine-scale (<100 μm) functional clusters form relative to voluntary forelimb movements. In addition, implications remain unclear. To address these issues, we conducted two-photon calcium imaging mouse layer 2/3 cortex during a self-initiated lever-pull task. session after 8–9 days training, head-restrained mice had pull lever for ∼600 ms receive water drop, then wait >3 s...
A variety of epileptic seizure models have shown that activation glutamatergic pyramidal cells is usually required for rhythm generation and/or synchronization in hippocampal seizure-like oscillations vitro . However, it still remains unclear whether GABAergic interneurons may be able to drive the without transmission. Here, we found electrical stimulation rat CA1 slices induced a putative prototype (“prototypic afterdischarge,” 1.8–3.8 Hz) mature and presence ionotropic glutamate receptor...
Lateral habenula (LHb) has attracted growing interest as a regulator of serotonergic and dopaminergic neurons in the CNS. However, it remains unclear how LHb modulates brain states animals. To identify neural substrates that are under influence regulation, we examined effects rat lesions on hippocampal oscillatory activity associated with transition states. Our results showed lesion shortened theta duration both anesthetized sleeping rats. Furthermore, this inhibitory effect maintenance...
Sequential motor behavior requires a progression of discrete preparation and execution states. However, the organization state-dependent activity in neuronal ensembles cortex is poorly understood. Here, we recorded spiking local field potential from rat during reward-motivated movement observed robust behavioral coordination between spiking, γ oscillations, θ oscillations. Slow fast oscillations appeared distinct states entrained firing. turn, were coupled to neurons encoding different fired...
It is known that GABA, a major inhibitory transmitter in the CNS, acts as an excitatory (or depolarizing) transiently after intense GABA A receptor activation adult brains. The depolarizing effect considered to be dependent on two receptor-permeable anions, chloride (Cl – ) and bicarbonate (HCO 3 ). However, little about their spatial temporal profiles during GABAergic depolarization postsynaptic neurons. In present study, we show amplitude of synaptically induced response was correlated...
Noninvasive imaging techniques showed that the anterior cingulate cortex is related to higher-order cognitive and motor-related functions in humans. To elucidate cellular mechanism of such functions, single-unit activity was recorded from three motor areas macaque monkeys performing delayed conditional Go/No-go discrimination tasks using spatial (location) nonspatial (color) visual cues. Unlike prefrontal neurons, only a few neurons coded information on individual features (e.g., "left" or...
This study introduces a new spike sorting method that classifies waveforms from multiunit recordings into trains of individual neurons. In particular, we develop to sort mixture generated by heterogeneous neural population. Such has significant practical value, but was previously difficult. The combines feature extraction method, which may term "multimodality-weighted principal component analysis" (mPCA), and clustering variational Bayes for Student's t model (SVB). performance the proposed...
In motor cortex, 2 types of deep layer pyramidal cells send their axons to other areas: intratelencephalic (IT)-type neurons specifically project bilaterally the cerebral cortex and striatum, whereas extratelencephalic (ET)-type, termed conventionally tract-type, ipsilaterally thalamus areas. Although they have totally different synaptic membrane potential properties in vitro, little is known about differences between them ongoing spiking dynamics vivo. We identified IT-type ET-type neurons,...
Two distinct motor areas, the primary and secondary cortices (M1 M2), play crucial roles in voluntary movement rodents. The aim of this study was to characterize laterality cortical representations right left forelimb movements. To achieve goal, we developed a novel behavioral task, Right-Left Pedal which head-restrained male rat manipulates or pedal with corresponding forelimb. This task enabled us monitor independent movements both forelimbs high spatiotemporal resolution. We observed...
Rodents have primary and secondary motor cortices that are involved in the execution of voluntary movements via their direct parallel projections to spinal cord. However, it is unclear whether rodent cortex has any function distinct from properly control movements. In present study, we quantitatively examined neuronal activity caudal forelimb area (CFA) rostral (RFA) head-fixed rats performing (pushing, holding, pulling a lever). We found virtually no major differences between CFA RFA...
The cerebellum has a parasagittal modular architecture characterized by precisely organized climbing fiber (CF) projections that are congruent with alternating aldolase C/zebrin II expression. However, the behavioral relevance of CF inputs into individual modules remains poorly understood. Here, we used two-photon calcium imaging in cerebellar hemisphere Crus mice performing an auditory go/no-go task to investigate functional differences modules. signals medial show anticipatory decreases,...
Previously, we introduced a monkey model for human frontal midline theta oscillations as possible neural correlate of attention. It was based on homologous found in the monkey's prefrontal and anterior cingulate cortices (areas 9 32) self-initiated hand-movement task. However, it has not been confirmed whether activity consistently appears other situations demanding Here, examined detailed properties four variations forewarned reaction time tasks with warning (S1) imperative (S2) stimuli. We...
Stereotaxic head fixation plays a necessary role in current physiological techniques, such as vivo whole cell recording and two-photon laser-scanning microscopy, that are designed to elucidate the cortical involvement animal behaviors. In rodents, however, often inhibits learning performance of behavioral tasks. particular, it has been considered inappropriate for head-fixed rodents be operantly conditioned perform skilled movements with their forelimb (e.g., lever-press task), despite...
We have recently reported that excitatory GABAergic and glutamatergic mechanisms may be involved in the generation of seizure‐like (ictal) rhythmic synchronization (afterdischarge), induced by a strong synaptic stimulation CA1 pyramidal cells mature rat hippocampus vitro . To clarify network mechanism this neuronal synchronization, dual whole‐cell patch‐clamp recordings afterdischarge responses were performed simultaneously from variety interneurones their neighbouring hippocampal...