A5093077966- Metalloenzymes and iron-sulfur proteins
- Cerebrovascular and genetic disorders
- Insurance, Mortality, Demography, Risk Management
- Child Nutrition and Water Access
- Health disparities and outcomes
- Birth, Development, and Health
- Neurological diseases and metabolism
- Moyamoya disease diagnosis and treatment
Leiden University Medical Center
2021-2024
University of Basel
2024
Pathogenic variants in
Importance Typical cysteine-altering NOTCH3 ( cys ) variants are highly prevalent (approximately 1 in 300 individuals) and associated with a broad spectrum of small vessel disease (SVD), ranging from early-onset stroke dementia (cerebral autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy [CADASIL]) to nonpenetrance. A staging system that captures the full -SVD severity is needed currently lacking. Objective To design simple clinicoradiological spectrum. Design, Setting,...
Abstract Background Although human longevity tends to cluster within families, genetic studies on have had limited success in identifying loci. One of the main causes this is selection participants. Studies generally include sporadically long-lived individuals, i.e. individuals with phenotype but without a predisposition for longevity. The inclusion these heterogeneity which results power reduction and bias. A way avoid reduce sample family history as criterion using score. challenge when...