A5100742031- Education and Learning Interventions
- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Educational Systems and Policies
- Alzheimer's disease research and treatments
- Diverse Approaches in Healthcare and Education Studies
- Nutrition, Health and Food Behavior
- Education, Safety, and Science Studies
- Antibiotic Resistance in Bacteria
- Brain Metastases and Treatment
- Diet and metabolism studies
- Parasites and Host Interactions
- Salmonella and Campylobacter epidemiology
- Educational Research and Pedagogy
- Viral gastroenteritis research and epidemiology
- Escherichia coli research studies
- Liver Disease Diagnosis and Treatment
- Bioactive natural compounds
- interferon and immune responses
- Pharmacological Effects of Natural Compounds
- Polysaccharides and Plant Cell Walls
- Phytoestrogen effects and research
- Bacteriophages and microbial interactions
- Tryptophan and brain disorders
- Brucella: diagnosis, epidemiology, treatment
Korea Disease Control and Prevention Agency
2022-2024
Korea Institute of Radiological and Medical Sciences
2024
Kyungpook National University
2005-2023
Korea Brain Research Institute
2023
Korea Institute of Toxicology
2016-2020
Pusan National University
2012-2020
Korea Research Institute of Chemical Technology
2020
Korea Basic Science Institute
2009-2020
University of Seoul
2020
Duke University
2016-2017
Depression is a serious medical illness that one of the most prevalent psychiatric disorders. Corticosterone (CORT) increases depression-like behavior, with some effects on anxiety-like behavior. 2-Phenethylamine (PEA) monoamine alkaloid acts as central nervous system stimulant in humans. Here, we show PEA exerts antidepressant by modulating Brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element binding protein (CREB) signaling pathway...
Although the use of RNAs has enormous therapeutic potential, these RNA-based therapies can trigger unwanted inflammatory responses by activation pattern recognition receptors (PRRs) and cause harmful side effects. In contrast, immune be advantageous for treating cancers. Thus, immunogenicity should deliberately controlled depending on applications RNAs. this study, we demonstrated that containing 2'fluoro (2'F) pyrimidines differentially PRRs. The activity stimulate toll-like 3 7 was...
Improved eating quality is a major breeding target in japonica rice due to market demand. Consequently, quantitative trait loci (QTL) for glossiness of cooked and amylose content associated with have received much research focus because their importance quality.In this study, QTL 12 grain traits were identified using 96 introgression lines (IL) developed from an interspecific cross between the Korean elite O. sativa cultivar 'Hwaseong' rufipogon over 7 years. analyses indicated that qDTH6...
Abstract Background Depression is a serious and common psychiatric disorder generally affecting more women than men. A woman’s risk of developing depression increases steadily with age, higher incidence associated the onset menopause. Here we evaluated antidepressant properties Asparagus cochinchinensis ( AC) extract investigated its underlying mechanisms in rat menopausal model. Methods To model this depression, induced menopause-like state rats via ovariectomy exposed them to chronic...
Apolipoprotein E (ApoE) polymorphism has been appreciated as a valuable predictor of Alzheimer disease (AD), and the associated ε4 allele recognized an indicator susceptibility to this disease. However, serum ApoE levels have controversial issue in AD, due great variability regarding different target detection methods, ethnicity, geographic variations cohorts. The aim study was validate relation particularly using two distinct liquid chromatography–selected reaction monitoring (SRM) mass...
Loperamide has long been known as an opioid-receptor agonist useful a drug for treatment of diarrhea resulting from gastroenteritis or inflammatory bowel disease well to induce constipation. To determine and characterize putative biomarkers that can predict constipation induced by loperamide treatment, alteration endogenous metabolites was measured in the serum Sprague Dawley (SD) rats treated with 3 days using (1)H nuclear magnetic resonance ((1)H NMR) spectral data. The amounts weights...
본 실험에서는 식이섬유와 비타민 C가 풍부한 식품인 바나나의 활용도를 높이기 위해 바나나 분말을 5, 10, 15, 20%첨가한 sponge cake 반죽의 비중, 점도, 반죽안정성과 첨가한 스펀지케이크의 수분함량, 일반성분, 부피, 무게, 색도, 조직감을 측정하고 관능검사를 실시하였다. 스펀지케이크 반죽 비중은 대조군과 5% 첨가군이 0.4였고 20% 첨가군까지는 유의적으로 증가하였다. 케이크 점도는 대조군보다 분말 첨가군들이 높게 나타났으며, Turbiscan을 이용하여 측정한 안정성은 10% 가장 나타났다. 수분함량은 첨가량이 증가할수록 유의적인 차이를 나타내었다. 외부와 내부 색도를 결과 외부의 L(명도)은 15% 낮았으며 45.41로 높은 값을 보였다. a(적색도)는 감소하였고, b(황색도)는 대조군이 20.35로 낮은 보였으며 22.59로 L(명도)과 감소하였으나 a(녹색도)는 감소하였다. 조직감 측정 시 경도(hardness)와 부서짐성(brittleness)은...
A 67-year-old woman presented with memory impairment and behavioral changes.Brain MRI indicated hepatic encephalopathy.Abdominal CT scans revealed an intrahepatic portosystemic venous shunt that consisted of two tracts to the aneurysmal sac communicated directly right vein.The large tract was successfully occluded by embolization using newly available AMPLATZERTM Vascular Plug II small coils.The patient's symptoms disappeared after closure she remained free recurrence at 3-month follow-up evaluation.
We investigated the effect of Lipofundin MCT/LCT and Intralipid on acetylcholine-induced nitric oxide- (NO-) mediated relaxation in rat aorta to determine which lipid emulsion (LE) is more potent terms inhibition NO-induced relaxation. Dose-response curves responses induced by acetylcholine, calcium ionophore A23187, sodium nitroprusside were generated using isolated with or without LE. The endothelial oxide synthase (eNOS) phosphorylation human umbilical vein cells (HUVECs) was western...
We describe two patients, with no previous history of vascular problems but poor lung function, who experienced septic shock due to bowel ischemia.Both were fed an enteral formula rich in fiber using a feeding tube and regular feeding.Surgical finding showed hemorrhagic ischemia the bowel.The pathologic suggests these changes may have been inspissations contents, which put direct pressure on mucosa wall, leading local impairment mucosal submucosal blood flow subsequent necrosis.Bowel...
In order to investigate the effects of a fermented soybean product (Chungkookjang, CKJ) on nerve growth factor (NGF) metabolism, NGF secretion ability and its related signaling pathway were analyzed in B35 neuronal cells Tg2576 mouse model Alzheimer's disease (AD). cells, concentration significantly increased upon treatment with Taegwang (TG)-CKJ Shinhwa (SH)-CKJ extracts compared vehicle. Further, significant increase PC12 cell length as well phsophorylation levels TrkA Akt, which are...
Liriope platyphylla is a medical herb that has long been used in Korea and China to treat cough, sputum, neurodegenerative disorders, obesity, diabetes. The aims of this study were determine the antidiabetic antiobesity effects aqueous extract L. (AEtLP) through glucose lipid regulation both pre-diabetes obesity stage type II diabetes model. Two concentrations AEtLP orally administrated OLETF (Otsuka Long-Evans Tokushima Fatty) rats once day for 2 weeks, after which changes metabolism fat...
An efficient enantioselective synthetic method for the synthesis of (2R)-5-phenyl-2-alkylproline tert-butyl esters was reported. The phase-transfer catalytic alkylation tert-butyl-5-phenyl-3,4-dihydro-2H-pyrrole-2-carboxylate in presence chiral quaternary ammonium catalysts gave corresponding alkylated products (up to 97% ee). following diastereoselective reductions afforded 5-phenyl-2-alkylprolines which can be applied asymmetric as organocatalysts or biologically active proline based...
The colibacillosis caused by avian pathogenic E. coli (APEC) is responsible for a significant loss of productivity and mortality in the poultry industry. pathogenicity these bacteria based on presence expression various virulence factors. In this study, 19 virulence-associated genes APEC was determined using PCR. Among 118 isolates from chickens with colibacillosis, all contained at least one as approximately 95% fimC. Interestingly, clpG gene, which has not been detected previously, half...