A5089512011- Genetics and Neurodevelopmental Disorders
- Neurogenesis and neuroplasticity mechanisms
- Effects and risks of endocrine disrupting chemicals
- Chromatin Remodeling and Cancer
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Wnt/β-catenin signaling in development and cancer
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Microplastics and Plastic Pollution
- Congenital heart defects research
- Extracellular vesicles in disease
- Per- and polyfluoroalkyl substances research
- Nerve injury and regeneration
- Fungal and yeast genetics research
- Cancer-related molecular mechanisms research
- Stress Responses and Cortisol
- Pharmacological Receptor Mechanisms and Effects
- Biochemical Analysis and Sensing Techniques
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hedgehog Signaling Pathway Studies
Korea Institute of Toxicology
2018-2025
Korea University of Science and Technology
2024-2025
Korea Research Institute of Chemical Technology
2020-2024
Nebraska Medical Center
2014-2017
University of Nebraska Medical Center
2014-2017
Boston Biomedical Research Institute
2011-2012
Chungnam National University
2006-2008
Balanced control of neural progenitor maintenance and neuron production is crucial in establishing functional circuits during brain development, abnormalities this process are implicated many neurological diseases. However, the regulatory mechanisms homeostasis remain poorly understood. Here, we show that mammalian target rapamycin (mTOR) required for maintaining pools plays a key role mediating glycogen synthase kinase 3 (GSK3) signaling development. First, generated characterized...
Impairment of microglial functions, such as phagocytosis and/or dysregulation immune responses, has been implicated an underlying factor involved in the pathogenesis various neurodegenerative disorders. Our previous studies have demonstrated that long intergenic noncoding RNA (lincRNA)-Cox2 expression is influenced by nuclear κB (NF-κB) signaling and serves a coactivator transcriptional factors to regulate vast array immune-related genes microglia. Extracellular vesicles (EVs) recognized...
De novo truncating mutations in ARID1B , a chromatin-remodeling gene, cause Coffin–Siris syndrome, developmental disorder characterized by intellectual disability and speech impairment; however, how the genetic elimination leads to cognitive dysfunction remains unknown. Thus, we investigated neural functions of during brain development. Here, show that regulates dendritic differentiation developing mouse brain. We knocked down expression pyramidal neurons using utero gene delivery...
Depression is a serious medical illness that one of the most prevalent psychiatric disorders. Corticosterone (CORT) increases depression-like behavior, with some effects on anxiety-like behavior. 2-Phenethylamine (PEA) monoamine alkaloid acts as central nervous system stimulant in humans. Here, we show PEA exerts antidepressant by modulating Brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element binding protein (CREB) signaling pathway...
Interneuron progenitors in the ganglionic eminence of ventral telencephalon generate most cortical interneurons during brain development. However, regulatory mechanism interneuron remains poorly understood. Here, we show that MTOR (mechanistic target rapamycin [serine/threonine kinase]) regulates proliferation and macroautophagy/autophagy developing telencephalon. To investigate role progenitors, conditionally deleted Mtor gene mouse their progeny by using...
Cocaine is a highly addictive narcotic associated with dendritic spine plasticity in the striatum. However, it remains elusive whether cocaine modifies spines cell type-specific or region-specific manner alters different types of synapses brain. In addition, there paucity data on regulatory mechanism(s) involved cocaine-induced modification density. current study, we report that exposure differentially density, morphology, and hippocampal cortical neurons. hippocampus resulted increased but...
GABAergic interneurons develop in the ganglionic eminence ventral telencephalon and tangentially migrate into cortical plate during development. However, key molecules controlling interneuron migration remain poorly identified. Here, we show that microtubule-actin cross-linking factor 1 (MACF1) regulates positioning developing mouse brain. To investigate role of MACF1 interneurons, conditionally deleted gene progenitors their progeny using Dlx5/6-Cre-IRES-EGFP Nkx2.1-Cre drivers. We found...
Bisphenol-A (BPA) is a representative endocrine disruptor, widely used in variety of products including plastics, medical equipment and receipts. Hence, most people are exposed to BPA via the skin, digestive system or inhalation everyday life. Furthermore, crosses blood-brain barrier linked multiple neurological dysfunctions found neurodegenerative neuropsychological disorders. However, mechanisms underlying BPA-associated remain poorly understood. Here, we report that exposure alters...
Perfluorinated compounds (PFCs), organofluoride comprising carbon–fluorine and carbon–carbon bonds, are used as water oil repellents in textiles pharmaceutical tablets; however, they associated with potential neurotoxic effects. Moreover, the impact of PFCs on neuronal survival, activity, regulation within brain remains unclear. Additionally, mechanisms through which induce toxicity not well-understood because paucity data. This study elucidates that perfluorooctanoic acid (PFOA)...
Abstract Background Depression is a serious and common psychiatric disorder generally affecting more women than men. A woman’s risk of developing depression increases steadily with age, higher incidence associated the onset menopause. Here we evaluated antidepressant properties Asparagus cochinchinensis ( AC) extract investigated its underlying mechanisms in rat menopausal model. Methods To model this depression, induced menopause-like state rats via ovariectomy exposed them to chronic...
Abstract Genetic evidence indicates that haploinsufficiency of ARID1B causes intellectual disability (ID) and autism spectrum disorder (ASD), but the neural function is largely unknown. Using both conditional global Arid1b knockout mouse strains, we examined role in progenitors. We detected an overall decrease proliferation cortical ventral progenitors following homozygous deletion , as well altered cell cycle regulation increased death. Each these phenotypes was more pronounced Furthermore,...
Early-life exposure to bisphenol A (BPA), synthetic compound used in polycarbonate plastic, is associated with altered cognitive and emotional behavior later life. However, the brain mechanism underlying behavioral deficits unknown. Here, we show that maternal BPA disrupted self-renewal differentiation of neural progenitors during cortical development. The reduced neuron number, whereas it increased glial cells cerebral cortex. Also, synaptic formation transmission cortex were suppressed...
A Bhas42 cell transformation assay is a method used to detect the tumour-promoting activities of chemicals. However, mechanisms underlying tumour transformations mediated by non-genotoxic carcinogens (NGCs) are poorly understood. This study aimed examine correlation between 12-O-tetradecanoylphorbol 13-acetate (TPA) or mezerein and initiation tumourous epigenetic regulation in cells. We found that TPA prompted stimulating proliferation migration Furthermore, we observed alterations...
Perfluorooctanoic acid (PFOA), a perfluoroalkyl acid, induces neuroinflammation. However, present understanding regarding its fundamental role in neuroinflammation remains limited. Therefore, this study, we aimed to clarify the potential association between PFOA and astrocyte activation via modulation of endoplasmic reticulum (ER) stress-autophagy axis. The results obtained revealed that activated astroglia A-172 astrocytoma cells primary astrocytes by upregulating expression levels...
Genetic predispositions can shape the gut microbiome, which in turn modulates host gene expression and impacts physiology. The complex interplay between genetics microbiome likely contributes to development of neuropsychiatric disorders, yet mechanisms behind these interactions remain largely unexplored. In this study, we investigated microbiota Negr1 knockout (KO) mice, exhibit anxiety- depression-like behaviors, as NEGR1 (neuronal growth regulator 1) is a cell adhesion molecule linked...
Corticosterone (CORT) can induce neuronal damage in various brain regions, including the cerebral cortex, region implicated depression. However, underlying mechanisms of these CORT-induced effects remain poorly understood. Recently, many studies have suggested that adipose stem cell-derived extracellular vesicles (A-EVs) protect neurons brain.To investigated neuroprotection A-EVs cortical neurons, we cultured from E15 mice for 7 days, and were pretreated with different numbers (5 × 105-107...