Ling Chen

ORCID: 0000-0003-0423-2100
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About
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Research Areas
  • Thyroid Cancer Diagnosis and Treatment
  • Head and Neck Anomalies
  • Thyroid and Parathyroid Surgery
  • S100 Proteins and Annexins
  • Biomarkers in Disease Mechanisms
  • Ferroelectric and Piezoelectric Materials
  • Multiferroics and related materials
  • Retinal Diseases and Treatments
  • Salivary Gland Tumors Diagnosis and Treatment
  • Immunotherapy and Immune Responses
  • Kruppel-like factors research
  • Monoclonal and Polyclonal Antibodies Research
  • Chronic Lymphocytic Leukemia Research
  • Breast Cancer Treatment Studies
  • Nicotinic Acetylcholine Receptors Study
  • Hormonal and reproductive studies
  • Retinal Imaging and Analysis
  • Clusterin in disease pathology
  • Magnetic and transport properties of perovskites and related materials
  • Glycosylation and Glycoproteins Research
  • Effects of Radiation Exposure
  • Cervical Cancer and HPV Research
  • Dielectric properties of ceramics
  • melanin and skin pigmentation
  • Viral-associated cancers and disorders

Columbia University
2023

First Affiliated Hospital of Jiangxi Medical College
2022

Chongqing Medical University
2020-2022

University of Alabama at Birmingham
2021-2022

The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2022

Fujian Medical University
2018-2021

First Affiliated Hospital of Fujian Medical University
2018-2021

Xi'an Jiaotong University
2010-2019

First Affiliated Hospital of Xi'an Jiaotong University
2013-2019

Fifth Affiliated Hospital of Sun Yat-sen University
2016

By validating optical coherence tomography angiography (OCTA) in the analysis of type 3 macular neovascularization secondary to age-related degeneration, overall value clinical OCTA for disease observation, diagnosis, and staging is increased.

10.1001/jamaophthalmol.2022.0890 article EN JAMA Ophthalmology 2022-04-21

Currently, there is no effective single antigen and are only a very limited number of complex antigens for the diagnosis early-stage breast cancer (BC). In this study, we used serological analysis recombinant cDNA expression libraries (SEREX) in combination with phage display technology to screen autoantigens from sera BC patients. The library was constructed using tissue samples three patients at as early stage T1N0M0. serum ten patients, including who provided samples, well five healthy...

10.1007/s13277-015-3932-y article EN Tumor Biology 2015-08-20

Summary Objective The Thyroid Imaging Reporting and Data System (TI‐RADS) is commonly used for risk stratification of thyroid nodules. However, this system has a poor sensitivity specificity. aim study was to build new model based on TI‐RADS evaluating ultrasound image patterns that offer improved efficacy differentiating benign malignant Design Patients population consisted 1092 participants with Measurements nodules were analysed by the model. prediction properties decision curve analysis...

10.1111/cen.13898 article EN Clinical Endocrinology 2018-11-03

There is very little published information regarding the prognostic value of hemoglobin (Hb) levels combined with smoking on survival patients nasopharyngeal carcinoma (NPC), and interactions between them remain unclear. A total 2440 NPC were confirmed, multivariate analysis was performed to identify valuable Hb in entire population cohort smokers. The differences compared using log-rank tests. multiplicative additive assessed Cox regression a Microsoft Word Excel spreadsheet....

10.1002/cam4.647 article EN cc-by Cancer Medicine 2016-01-28

Early diagnosis and prognosis monitoring are very important for the survival of patients with bladder cancer. To identify candidate biomarkers cancer, we used a combination techniques including 2-DE, co-IP, western blot, LC-MS/MS, immunohistochemistry. Hsp74 was identified high expression in The cellular location products gene showed that they were distributed into cytoplasm keratin 1 found to be associated Hsp74. results provide new idea understand molecular basis cancer progression...

10.1155/2014/492849 article EN cc-by Journal of Immunology Research 2014-01-01

Composite lead‐free piezoelectric and multiferroic thin films consisting of Bi 0.9 Dy 0.1 FeO 3 ( BDF ) K 0.5 Na NbO KNN nanolayers were prepared on the Pt / TiO 2 SiO Si substrates by pulsed laser deposition. The bilayered exhibited a preferential (100)‐orientation much enhanced ferroelectric properties (2 P r = 26.5 μC/cm , E c 369.2 kV/cm) as compared to those single layer or film. In addition, also showed ferromagnetic behavior at low temperature M 1.57 emu/cm H kOe). attributed...

10.1111/j.1551-2916.2012.05279.x article EN Journal of the American Ceramic Society 2012-06-05

Ti-modified 0.72BiFeO3–0.28PbTiO3 thin films were prepared on Pt/Ti/SiO2/Si substrates by pulsed laser deposition under different oxygen pressures from 2 Pa to 15 Pa. The microstructures and electrical properties investigated. Tetragonal (001) preferential orientation was observed in all atmosphere pressures. of the have been investigated for various conditions. dielectric constant double remanent polarization found be 550 80 μC/cm2, respectively, film deposited at an 10 a substrate...

10.1080/00150193.2010.492058 article EN Ferroelectrics 2010-11-02

Ultrasonography as the first choice for thyroid nodules is still difficult to distinguish between solid follicular neoplasm (FTN) and nodular goiter (NG). We tried investigate value of relative size (M/S, M: maximum diameter target nodule, S: largest remaining nodules) that may help differentiate FTN from NG.T test chi-square were used retrospectively analyze differences clinical ultrasonographic characteristics NG in 422 cases our hospital. T was difference M/S two kinds nodules. ROC...

10.2147/ijgm.s313468 article EN cc-by-nc International Journal of General Medicine 2021-06-01

Background: Mostly current studies are limited to the impact of lymph node metastasis(LNM) on prognosis papillary thyroid cancer(PTC) or glucose metabolism occurrence PTC, but no one has paid attention connection between fasting serum glucose(FSG) and LNM. The purpose our study was explore relationship FSG LNM in non-diabetic PTC patients. Methods: In this study, we performed a multicenter, retrospective 6034 patients with PTC. associations three types including central metastasis (CLNM),...

10.7150/jca.71514 article EN cc-by-nc Journal of Cancer 2022-01-01

Abstract The nucleus accumbens (NAc) is a key part of the neural circuitry that creates reward, pleasure and motivation facilitates human feeding, sexual smoking behaviors. In brain reward system, NAc crucial component responsible for natural drug-induced reinforcement Yet it unclear whether indispensible all behaviors in beings. present study aimed to investigate long-term effects ablation on function, appetite, nicotine dependence level chronic heroin users. Eighteen former...

10.2478/s13380-013-0146-x article EN cc-by-nc-nd Translational Neuroscience 2013-12-01

The rare BRAF L597Q (c.T1790A) point mutation has been previously reported in childhood acute lymphoblastic leukemia. We present the first case of occult papillary thyroid carcinoma with a Tibetan patient.A 57-year-old male patient presented protruding mass on left forehead for 2 years and numbness right limb 3 weeks.The had double V600E separate lesions at brain, immunohistochemical staining showed that cytokeratin (CK), thyroglobulin (Tg) transforming factor-1 (TTF-1) were immunoreactive....

10.1097/md.0000000000024458 article EN cc-by-nc Medicine 2021-02-12

Objective To investigate the correlation of expression BRAFV600E gene mutation and protein clinicopathological features in patients with papillary thyroid carcinoma (PTC). Methods We collected 164 cases PTC, were detected by fluorescent quantitative PCR immunohistochemical method, combined analyzed. Results In PTC cancer tissues, 86.6% (142/164) had mutation, 80.5% (132/164) expression, 90.1% (130/143) expression. In 78.7% (129/164) patients, at same time. Patients together,...

10.3760/cma.j.issn.1001-9030.2018.03.038 article EN Zhonghua shiyan waike zazhi 2018-03-08

Objective To investigate the protein expression of BRAFV600E/telomerase reverse transcriptase (TERT) in patients with papillary thyroid cancer (PTC) and its correlation lung metastasis. Methods The tumor tissues 716 PTC were collected. The BRAFV600E TERT was detected by immunohistochemistry, their clinical pathological features analyzed. Results In these patients, 62.3% (446/716) expressed protein, 30.9% (221/716) 18% (129/716) co-expressed proteins. Multivariate analysis...

10.3760/cma.j.issn.1001-9030.2019.08.036 article EN Zhonghua shiyan waike zazhi 2019-08-08

Abstract Background: With the increasing incidences of papillary thyroid cancer(PTC), it is important to risk-stratify patients who may have more aggressive tumor biology. This study aimed evaluate risk factors for lymph node metastasis with PTC in Southwest China Patients which provide a substantial reference clinical diagnosis and treatment. Methods: 1045 PTCs (313 PTMC 732 non-PTMC) between August 2016 2019 were examined totally (including one Tibetan). BRAF V600E mutation was tested all...

10.21203/rs.3.rs-26100/v1 preprint EN cc-by Research Square (Research Square) 2020-05-05
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