A5100395550- Spondyloarthritis Studies and Treatments
- Osteoarthritis Treatment and Mechanisms
- Systemic Lupus Erythematosus Research
- IgG4-Related and Inflammatory Diseases
- Rheumatoid Arthritis Research and Therapies
- GDF15 and Related Biomarkers
- Pancreatitis Pathology and Treatment
- Cytokine Signaling Pathways and Interactions
- Neuroendocrine Tumor Research Advances
- Macrophage Migration Inhibitory Factor
- Inflammatory Bowel Disease
- Bone health and treatments
- Inflammatory mediators and NSAID effects
- Autoimmune and Inflammatory Disorders Research
- Bone and Joint Diseases
- Gut microbiota and health
- Kawasaki Disease and Coronary Complications
- Neurofibromatosis and Schwannoma Cases
- Genetic Syndromes and Imprinting
- Nuclear Receptors and Signaling
- Cancer Research and Treatments
- Inflammasome and immune disorders
- Hepatitis C virus research
- Heterotopic Ossification and Related Conditions
- Ocular Diseases and Behçet’s Syndrome
Zhejiang Chinese Medical University
2021-2024
Sun Yat-sen University
2012-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2019-2024
Affiliated Hospital of Qingdao University
2015-2023
Qingdao University
2015-2023
General Hospital of Shenyang Military Region
2023
Sichuan University
2013-2022
West China Hospital of Sichuan University
2013-2022
Johns Hopkins Medicine
2022
Johns Hopkins University
2022
Ankylosing spondylitis (AS) is a systemic, chronic, and inflammatory autoimmune disease associated with the disorder of intestinal microbiota. Unfortunately, effective therapies for AS are lacking. Recent evidence has indicated that indole-3-acetic acid (IAA), an important microbial tryptophan metabolite, can modulate homeostasis suppress responses. However, reports have not examined in vivo protective effects IAA against AS. In this study, we investigated underlying mechanisms through which...
Objective To explore the associations between metabolic syndrome (MetS) and its individual components risk of rheumatoid arthritis (RA). Methods A total 369,065 individuals were included in present study based on UK Biobank. Multivariable Cox proportional hazards regression models applied to estimate MetS RA. Mediation analysis was performed further assess potential mediating role C-reactive protein (CRP) relationship Results During a median follow-up period 12.04 years, 4901 incident RA...
Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by sacroiliac joint lesions and spinal ascending involvement. The aim of this work was at investigating the gut microbiota profile proinflammatory cytokines in AS patients. Gut patients clearly different from that healthy human controls. 16S rRNA sequencing analysis demonstrated changed microbial diversity patients, there significant increase abundance Cyanobacteria, Deinococcota, Patescibacteria, Actinobacteriota,...
Abstract Ankylosing spondylitis is a chronic, progressive disease, and its treatment relevant to the gut microbiota. Anti‐tumor necrosis factor‐alpha (anti‐TNF‐α) therapy alters microbiota in many diseases, including inflammatory bowel disease. However, little known about effect of TNF‐α blocker on ankylosing spondylitis. Herein, proteoglycan‐induced arthritis was investigated. Proteoglycan‐induced mice were treated with an rhTNFR:Fc solution etanercept (5 µg/g) for 4 weeks. attenuated...
Many musculoskeletal disorders (MDs) are associated with irreversible bone and cartilage damage; this is particularly true for osteoarthritis (OA). Therefore, a clinical need exists modalities which can detect OA other MDs at early stages. Optical coherence tomography (OCT) an infrared-based imaging, currently FDA approved in cardiology ophthalmology, has resolution greater than 10 microns acquisition rate of 120 frames/second. It shown feasibility imaging OA, identifying changes prior to...
To explore the optimal steroid therapeutic strategy for autoimmune pancreatitis (AIP).This study was conducted retrospectively in two large institutions China. Patients with clinically, radiologically and biochemically diagnosed AIP were enrolled. The performed radiological investigations biochemical tests, regimen of given treatment, remission relapse whether without therapy analyzed.Twenty-eight patients received while 40 treated surgically by pancreatoduodenectomy, distal pancreatectomy...
A previously healthy 8-year-old girl underwent MDP bone scintigraphy to evaluate possible spondylolysis due worsening back pain. Unexpectedly, the scan images revealed intense activity in several thoracic and lumbar vertebrae, which was not consistent with spondylolysis. Further examinations proved that patient had acute lymphocytic leukemia.
Intracranial atherosclerotic stenosis (ICAS), the most common cause of stroke worldwide, is associated with high risk recurrent ischemic stroke. F-box and WD repeat domain containing protein 7 (FBW7), an ubiquitin E3 ligase, recently suggested to be involved in atherogenesis. However, whether FBW7 affects cerebrovascular remodeling during ICAS remains unknowns. We found that expression was decreased mouse brain microvessels from high-fat diet (HFD)-fed mice. The reduced negatively middle...
To investigate the potential causal associations of circulating levels growth differentiation factor 15 (GDF-15) with risk systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) using a Mendelian randomization (MR) design.A genome-wide association study (GWAS) GDF-15 among 5,440 individuals European ancestry was used to identify genetic instruments. Summary statistics SLE, RA IBD were obtained from publicly available GWASs. We conducted an MR...
We investigated the therapeutic effects of a craniosynostosis-associated molecule, NEL-like molecule-1 (NELL1; NEL [a protein strongly expressed in neural tissue encoding epidermal growth factor-like domain]), on osteolysis induced by polyethylene (PE)-particle debris. used murine calvarial model with vivo adenovirus (Ad)-mediated gene transfer. In total, 76 female Balb/c mice were randomly assigned to four groups for treatment 1 day postoperation: SHAM (injected 0.1 mL saline without...
Distal extremity swelling with pitting edema in psoriatic arthritis (PsA) is a rare rheumatological condition, whose management presents challenge. The aim of the present study was to identify clinical characteristics of, and formulate standardized strategy for, patients distal PsA. medical records consecutive PsA, or without edema, were systematically analyzed over ~10-year period (between September 2008 2018) single center comprehensive review (pathogenic mechanisms, manifestations,...
Ankylosing spondylitis (AS), is known as a chronic inflammatory autoimmune disease, there evidence to suggest that gut microbiota disorders may be related the occurrence and development of AS. Studies have shown 6-formylindolo[3, 2-b]carbazole (FICZ) has ability modulate intestinal homeostasis inhibit responses. The purpose this work evaluate protective role FICZ in treating AS elucidate potential mechanisms. was administered proteoglycan (PG)-induced mice for 7 consecutive weeks. effects on...
Systemic lupus erythematosus (SLE), characterized by the production of autoantibodies and widespread deposition immune complexes, predominantly affects women childbearing age. More than one-third SLE patients present ocular manifestations. Choroidal disease is currently not completely understood, its precise differentiation from central serous chorioretinopathy rarely achieved. To date, no more 60 with choroidal involvement have been reported.A 37-year-old Chinese woman experienced decreased...
Glycogen storage disease type Ia (GSDIa) is an autosomal recessive inborn error of carbohydrate metabolism that caused by deficiency the enzyme glucose-6-phosphatase (G6Pase), leading to disturbed glycogenolysis and gluconeogenesis. Patients with GSDIa show severe fasting hypoglycemia, hyperlipidemia, hyperlactacidemia, hyperuricemia, which are associated fatal outcomes in pregnant women fetuses.Herein, we report case a 24-year-old female who on her first visit hospital, presented pregnancy...