A5069733912- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Stress Responses and Cortisol
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Lipids, and Metabolism
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Surgical site infection prevention
- Tryptophan and brain disorders
- Healthcare Policy and Management
- Behavioral and Psychological Studies
- Lung Cancer Treatments and Mutations
- Hip and Femur Fractures
- Neuroscience and Neuropharmacology Research
- Health disparities and outcomes
- Healthcare Decision-Making and Restraints
- Frailty in Older Adults
- Hormonal Regulation and Hypertension
- Cancer Genomics and Diagnostics
- Structural Health Monitoring Techniques
- Nosocomial Infections in ICU
Memorial Sloan Kettering Cancer Center
2022-2024
American College of Surgeons
2016-2023
Kettering University
2023
Temple University
2017-2020
Northeastern University
2018-2020
Icahn School of Medicine at Mount Sinai
2020
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2020
The Ohio State University
2020
WellSpan York Hospital
2016
Thomas Jefferson University Hospital
2016
Objective: Our aims were to assess North American trends in the management of patients undergoing pancreatoduodenectomy (PD) and distal pancreatectomy (DP), quantify delivery optimal pancreatic surgery. Background: Morbidity after remains unacceptably high. Recent literature suggests that composite measures may more accurately define surgical quality. Methods: The 2013 2017 College Surgeons National Surgical Quality Improvement Program Participant Use Files queried identify PD (N = 16,222)...
Cisplatin-induced acute kidney injury (CI-AKI) is a significant co-morbidity of chemotherapeutic regimens. While this condition associated with substantially lower survival and increased economic burden, there no pharmacological agent to effectively treat CI-AKI. The disease hallmarked by tubular necrosis the proximal epithelial cells primarily due oxidative stress. We investigated drug delivery strategy improve pharmacokinetics an approved therapy that does not normally demonstrate...
Objective: Establish the association between bactibilia and postoperative complications when stratified by perioperative antibiotic prophylaxis. Background: Patients undergoing pancreatoduodenectomy (PD) experience high rates of surgical site infection (SSI) clinically relevant pancreatic fistula (CR-POPF). Contaminated bile is known to be associated with SSI, but role prophylaxis in mitigation infectious risks ill-defined. Methods: Intraoperative cultures (IOBC) were collected as an adjunct...
We have studied the influence of pre-training psychological stress on expression c-fos mRNA following long-term spatial memory retrieval. Rats were trained to learn location a hidden escape platform in radial-arm water maze, and then their for was assessed 24 h later. Rat brains extracted 30 min after 24-h test trial analysis mRNA. Four groups tested: (1) given standard training (Standard); (2) cat exposure (Predator Stress) prior (Pre-Training Stress); (3) only (Water Yoked); (4) no (Home...
A marginal maximum a posteriori (MMAP) procedure was implemented to estimate item parameters in the generalized graded unfolding model (GGUM). Estimates from MMAP method were compared with those derived likelihood (MML) and Markov chain Monte Carlo (MCMC) procedures recovery simulation that varied sample size, questionnaire length, number of response categories. parameter estimates generally most accurate had smallest standard errors on average. In contrast, accuracy variability MML suffered...
Stress-induced activation of hypothalamic paraventricular nucleus (PVN) corticotropin-releasing hormone (CRH) neurons trigger CRH release and synthesis. Recent findings have suggested that this process depends on the intracellular (phosphorylation) ERK1/2 within neurons. We recently shown presence glucocorticoids constrains stress-stimulated phosphorylation PVN ERK1/2. In some peripheral cell types, dephosphorylation ERK has been to be promoted by direct glucocorticoid upregulation MAP...
Use of postoperative antimicrobial prophylaxis is common in pediatric surgery despite consensus guidelines recommending discontinuation following incision closure. The association between use and surgical site infection (SSI) children undergoing procedures remains poorly characterized.To evaluate whether correlated with SSI rates nonemergent surgery.This a multicenter cohort study using 30-day data from the American College Surgeons' Pediatric National Surgical Quality Improvement Program...
Microglia are resident immune cells of the brain that can regulate neural communication and excitability. Any environmental influence on microglial activity has potential to alter subsequent physiology behavior. Within prefrontal cortex, several types stressors have been shown increase expression activation markers such as ionized calcium-binding adapter molecule-1 (Iba-1), which suggests altered activity. Recent reports in rodents suggest exposure forms early-life stress maternal separation...
BackgroundWhether the choice of antibiotic prophylaxis, type incision, or use wound protectors decreases surgical site infections (SSIs) in patients undergoing pancreatoduodenectomy (PD) remains unknown.MethodsPatients open, elective PD between January 1, 2016 and June 30, 2017 were identified from American College Surgeons’ National Surgical Quality Improvement Program registry. Multivariable logistic regression models constructed to determine association prophylaxis type, incision...
A system of systems modeling approach can be used to plan and guide implementation economic revitalization efforts. key metric success is the improved outcomes individuals in terms standard living subjective well-being. Initial results for a latent variable model based on national survey data show moderate correlation between well-being objective measures living, good fit three-factor that relates economic, security, social network variables human capital. Human capital production within...
Objective: The aim of the study was to determine association patient-reported experiences (PREs) and risk-adjusted surgical outcomes among group practices. Background: Centers for Medicare Medicaid Services required large practices submit PREs data successful participation in Physician Quality Reporting System (PQRS) using Consumer Assessment Healthcare Providers Systems PQRS survey. Whether these correlate with perioperative remains ill defined. Methods: Operations between January 1, 2014...