The current study aims to investigate the hepatoprotective effects of LivPro® among hepatitis C patients. An interventional was performed n=89 duration 3 months and assessment for liver function, ELISA, Viral load monthly patients recruited in this study. Mean difference measured at a Confidence Interval (CI 95%) p-value less than 0.05 considered statistically significant. This stu

Abstract Avian influenza A(H9N2) virus isolated from a poultry worker in Pakistan 2015 was closely related to viruses detected farms. Observed mutations the hemagglutinin receptor-binding affinity and antigenicity could affect cross-reactivity with prepandemic H9N2 vaccine strains.

Surveillance of H9N2 is currently focused on areas central to the commercial poultry industry. This study determined prevalence virus in and backyard flocks Punjab Province, Pakistan. Oral tracheal swabs were collected from January 2015 through June 2016. Antisera against H5, H7, H9, Newcastle disease viruses used for identification. Molecular confirmation was made by reverse transcription PCR. Avian influenza subtypes H5 H7 not detected. The isolated 5.7% 905 tested (5-10 birds/flock)....

The most useful treatment for HCV infection worldwide is peg-interferon plus ribavirin, although the response varies from person to person. Hence, host genetics are significantly involved in infection. 2'-5' oligoadenylate synthetase (OAS) one of important components immune system having significant antiviral functions. aim this study was investigate role single nucleotide polymorphism (SNP) at exon 7 splice acceptor site (SAS) OAS1 interferon-based therapy genotyping performed 140 patients...

Hepatitis B virus (HBV) and hepatitis C (HCV) are the major cause of global burden hepatitis. One main routes transmission for both viruses is through exposure to infected blood, which includes sharing blood-contaminated syringes needles. Human immunodeficiency (HIV) attacks immune system results in acquired deficiency syndrome opportunistic infections. The objective this study was assess epidemiology HBV HCV infections among HIV-infected people who inject drugs (PWID). enrolled 100 PWID...

Pakistan has the second highest burden of hepatitis C (HCV) in world. The major route HCV transmission is contaminated blood or needle sharing. Seventy percent people who inject drugs (PWIDs) shared needles at some time their addiction history. aim present study was to estimate prevalence PWIDs cities Pakistan. We enrolled 100 from Rawalpindi and Islamabad Blood samples were taken collection tubes subjected screening by using three rapid kits including one step anti‑HCV test, onsite Ab test...

Hepatitis C virus (HCV) genotypes and genetic variants of interleukin 28B (IL28B) are significantly associated with interferon plus ribavirin treatment HCV infection. We investigated the distribution single-nucleotide polymorphisms (SNPs) IL28B (rs12979860 rs8099917) in Pakistani population. genotyping was performed by allele-specific PCR restriction fragment length polymorphism 140 chronic hepatitis patients (CHC) 120 healthy controls. genotype 3 (HCVG3) most prevalent genotype, 71.4% (n =...

The adaptive immune system plays an important role in response to interferon plus ribavirin treatment of hepatitis C virus (HCV) infection. Cytokines play a significant the system. production cytokines may be regulated by single nucleotide polymorphisms (SNPs). This study was designed examine correlation some SNPs with HCV infection Pakistani population. We followed 140 chronic HCV-infected patients our study. All these had completed their planned course treatment. also considered 120...

Hepatitis B and C are the major causes of morbidity mortality in Pakistani population their influence is considerable patients suffering from kidney diseases undergoing dialysis (Haemodialysis/ Peritoneal).This study considered total number a patient received week with chances infection.This cross sectional was conducted to determine frequency hepatitis either haemodialysis or peritoneal dialysis.Serum sample extracted blood 60 patients.All were chronic disease acute renal failure.Screening...

Objective: The objectives were to assess the frequency of hospital acquired pneumonia (HAP) in patients admitted intensive care unit (ICU) and determine frequencies different etiological organisms these patients.Methods: This was descriptive cross sectional study, which carried out medical ICU Shifa International Hospital Islamabad from January 2013 2014. A total 1866 department medicine including ICU. They evaluated for HAP causative cultured patients. Identification by standard biochemical...

Although many countries are now collecting useful, high-quality HIV surveillance data, more efforts put into the collection of data than ensuring it is deployed effectively.The Canada-Pakistan HIV/ AIDS project has strengthened and expanded existing national control programme system in Pakistan through a comprehensive estimate size location some most at-risk populations (sex workers injection drug users) annual assessments their sociodemographic characteristics, behaviours prevalence.The...

BZ collected the samples and performed experiments.MSI contributed in histopathology.MY analyzed data.TY executed serum antibody titer.

Indirect linkage analysis using highly informative polymorphic markers is the method of choice for carrier detection hemophilia A in developing countries because direct DNA or mRNA sequence manifold costly and difficult than indirect gene tracking. Worldwide populations have revealed marked variation informativeness which each country has to select its own panel families. The present study aimed at determining three factor VIII polymorphisms [intron 13(CA)n repeats, HindIII AlwNI] Pakistani...

The current research was conducted to investigate and compare the role of functional foods such as probiotics prebiotics alone or in combinations on markers liver damage, oxidative stress inflammatory nonalcoholic fatty disease (NAFLD) induced rats. According results, G3, G4 G6 gained significant weight at end study. Moreover, weights different organs (liver, Spleen kidney) revealed that G1 (control negative) fed a standard diet lowest weight, G2 positive) high fat (HFD) maximum (9.63 ± 0.46...

Hepatitis C virus remained a public health problem with approximately half of the patients untreated and undiagnosed. Chronic HCV is leading cause cirrhosis, fibrosis, hepatocellular carcinoma other hepatic morbidities. Active has prevalence rate about 1% (71 million). By July, 2019, 10 million population Pakistan was declared to have active infection. According World Health Organization, 23,720 people died hepatitis-related complexities in 2016. Individuals certain types ABO blood groups...

<h3>Introduction</h3> Khat is well recognised for its hepatotoxic effects. The exact mechanism by which it causes liver damage remains unknown. We report a series of patients with history khat use presenting acute hepatitis, and review the potential role in triggering auto immune hepatitis (AIH). <h3>Methods</h3> database at Sheffield Hospitals was searched referred to Hepatology department between 2005 2010 problems use. They were then assessed probability having AIH using revised criteria...

Newcastle disease (ND) is an infectious, highly contagious and lethal of avian species. It considered that ducks are natural reservoir or carrier for virus (NDV) resistant against different strains NDV. Current study was designed to evaluate the pathogenesis in domestic through histopathology, immunohistochemistry (IHC) serum biochemical changes. For this purpose, eighty were reared 42 days divided two groups A B. Ducks group challenged with at rate 0.1 ml ELD50 (virus titer 107.32/100µl) on...