A5024484596- Venous Thromboembolism Diagnosis and Management
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Biochemical effects in animals
- Blood Coagulation and Thrombosis Mechanisms
- Tryptophan and brain disorders
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Nerve injury and regeneration
- Pharmacological Receptor Mechanisms and Effects
- Pain Mechanisms and Treatments
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Neuropeptides and Animal Physiology
- Acute Ischemic Stroke Management
- Peroxisome Proliferator-Activated Receptors
- Cardiac Health and Mental Health
- Blood properties and coagulation
- Phytoestrogen effects and research
- Nuclear Receptors and Signaling
- Cancer Cells and Metastasis
- Brain Metastases and Treatment
- Acute Myocardial Infarction Research
- Gut microbiota and health
Institute of Biomedical Chemistry
2023-2025
Institute of Pharmacology Russian Academy of Medical Sciences
2018-2024
Zdravstveni centar
2020
National University of Food Technologies
2011
George Washington University
2002
Nowadays the special attention of scientists is focused on flaxseed that rich in polyunsaturated fatty acids ω-3 and ω-6, proteins, water-soluble polysaccharides, dietary fibre, lignin, vitamins, minerals phenolic compounds. Paying caused by ability to have a great influence human health, prevent cardiovascular diseases, gastrointestinal problems cancer. New butter with additive technology were developed us. The suspension microstructure was studied. It revealed multicomponent structured...
Abstract Cardiovascular disease (CVD) represents one of the main causes mortality worldwide and nearly a half it is related to ischemic heart (IHD). The article comprehensive study on diagnostics IHD through targeted metabolomic profiling machine learning techniques. A total 112 subjects were enrolled in study, consisting 76 patients 36 non-CVD subjects. Metabolomic was conducted, involving quantitative analysis 87 endogenous metabolites plasma. novel regression method age-adjustment...
Aim. To evaluate the efficacy and safety of single bolus administration non-immunogenic staphylokinase in comparison with placebo patients intermediatehigh risk pulmonary embolism (PE) within FORPE-2 clinical trial. Material methods . Non-immunogenic has high thrombolytic activity fibrin selectivity. The trial a multicenter, doubleblind, randomized, placebo-controlled design. In sites, (486 total, possible 10% dropout rate) confirmed PE evidence right ventricular dysfunction based on...
Background/Objectives: Our study brings a new method to properly evaluating drug efficacy at the non-invasive in vitro level. Methods: In this work, electrochemical mediator-free and reagent-free analysis of cell lines based on registration profiles membrane proteins was developed. We studied specificity Wi-38 HepG2 toxic effects drugs cell-on-electrode systems. Results: A linear dependence peak current concentration cells applied electrode range from 1 × 105 6 cells/electrode registered (R2...
This article discusses the role of phospholipids as a key component high-density lipoproteins (HDL) involved in reverse transport cholesterol from cells with its subsequent excretion body. The results phospholipidation research on capacity HDL efflux macrophages, well an assessment hypolipidemic and antiatherogenic effects atherosclerosis rabbit model at functional morphological levels are presented. In phase I clinical trial safety oral administration innovative water-soluble pharmaceutical...
ABSTRACT Background and Aims Major bleedings are the most limiting factor of usage thrombolytic agents in pulmonary embolism (PE), especially elderly patients. Non‐immunogenic staphylokinase is a recombinant with high activity, fibrin selectivity, low immunogenic properties. We performed post hoc analysis safety outcomes patients massive PE over 60 years' old who received non‐immunogenic FORPE trial. Methods A randomized, open‐label, multicenter, parallel‐group, noninferiority trial was...
Abstract Myocardial infarction is a major cause of morbidity and mortality worldwide. Metabolomic investigations may be useful for understanding the pathogenesis ST-segment elevation myocardial (STEMI). STEMI patients were comprehensively examined via targeted metabolomic profiling, machine learning weighted correlation network analysis. A total 195 subjects, including 68 patients, 84 with stable angina pectoris (SAP) 43 non-CVD enrolled in study. profiling involving quantitative analysis 87...
One of the key factors in pathogenesis diabetes and its complications is oxidative stress. To inhibit this process, antioxidants may be helpful. Herein, we focused on protective properties taxifolin spheroidal form (TS) streptozotocin rat model mellitus. After 4 weeks treatment with TS, fasting blood glucose level diabetic animals decreased by 12% compared right after injection streptozotocin. While feed intake untreated rats increased 5.3% healthy group, TS-treated group showed a pronounced...
We investigated the cytoprotective effect of a novel low-molecular-weight NGF mimetic, GK-2 (hexamethylenediamide bis-N-monosuccinyl-L-glutamyl-L-lysine), on pancreatic -cells. The neuroprotective had been previously shown to be associated with selective activation PI3K/Akt signaling pathway. In this study, rats streptozotocin (STZ)-induced type 2 diabetes mellitus were used. Metformin was used as reference drug. STZ immunohistochemically demonstrated reduce number -cells and affect their...
Aim . To assess the safety and efficacy of a single intravenous bolus non-immunogenic staphylokinase compared with alteplase in patients massive pulmonary embolism hemodynamic instability. Non-immunogenic is modified recombinant low immunogenicity, high thrombolytic activity fibrin selectivity. Material methods This multicenter, open-label, randomized, comparative clinical trial FORPE two parallel groups was conducted 23 centers Russia. A total 310 aged 18 years older instability computed...
Signs of metabolic syndrome and prediabetes preceding type 2 diabetes are modelled in an experiment using a high-fat diet (HFD). The aim this work was to study the effect low molecular weight systemically active nerve growth factor mimetic, compound GK-2 (hexamethylenediamide bis[N-monosuccinyl-L-glutamyl-L-lysine]), on indicators abdominal obesity, basal blood glucose level, tolerance, cholesterol triglyceride levels, as well morphological structure liver male Wistar rats fed HFD. Rats were...
Relevance. To conduct a preclinical evaluation of the effectiveness antidiabetic drugs, models simulating pathogenesis and main manifestations diabetes mellitus (DM) in humans are needed. The streptozotocin (STZ) model, which has received most widespread use experiment, does not allow reproducing stepwise multifactorial development type 2 diabetes. Goal. develop model using high-carbohydrate diet combination with subthreshold dose STZ Wistar rats, characterized by hyperglycemia insulin...
Abstract Background. Acute myocardial infarction (AMI) represents a major cause of morbidity and mortality worldwide. Metabolomics investigation may be useful in the AMI pathogenesis research. Materials methods. The article describes comprehensive study through targeted metabolomic profiling. A total 195 subjects were enrolled study, consisting 68 patients, 84 IHD patients 43 non-CVD subjects. Metabolomic profiling was conducted, involving quantitative analysis 87 endogenous metabolites...
Acute lung injury (ALI) as a model of acute respiratory distress syndrome is characterized by inflammation, complex coagulation, and hematologic abnormalities which result in the formation fibrin-platelet microthrombi pulmonary vessels with rapid development progressive dysfunction. We hypothesize that nebulized fibrinolytic agent, non-immunogenic staphylokinase (nSta), may be useful for ALI therapy. First, effect nSta (0.2 mg/kg, 1.0 or 2.0 mg/kg) on coagulogram parameters was studied...