A5013554035- Spaceflight effects on biology
- Laser Applications in Dentistry and Medicine
- High Altitude and Hypoxia
- Mesenchymal stem cell research
- Medical and Biological Ozone Research
- Neonatal Respiratory Health Research
- Cleft Lip and Palate Research
- GABA and Rice Research
- Virus-based gene therapy research
- Nerve injury and regeneration
- Tissue Engineering and Regenerative Medicine
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Function and Risk Factors
- Cervical Cancer and HPV Research
- Oral health in cancer treatment
- Cannabis and Cannabinoid Research
- Neuroscience of respiration and sleep
- Nanofabrication and Lithography Techniques
- Cardiac Fibrosis and Remodeling
- Immunotoxicology and immune responses
- Neuroscience and Neuropharmacology Research
- Platelet Disorders and Treatments
- Pediatric health and respiratory diseases
- Wound Healing and Treatments
- Biochemical and Structural Characterization
Privolzhsky Research Medical University
2016-2023
Morpho (United States)
2016
Genetika
2015
N. I. Lobachevsky State University of Nizhny Novgorod
2015
Sechenov University
2015
There is a need for better strategies to promote burn wound healing and prevent infection. The aim of our study was develop an easy-to-use placental multipotent mesenchymal stromal cell (MMSC) secretome-based chitosan hydrogel (MSC-Ch-gel) estimate its antimicrobial regenerative activity in Staphylococcus aureus-infected wounds rats.Proteomic studies the MMSC secretome revealed proteins involved regeneration, angiogenesis, defence responses. collected from cultured cells mixed with...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is a common clinical problem, leading to significant morbidity mortality, no effective pharmacotherapy exists. The problem of ARDS causing mortality became more apparent during the COVID-19 pandemic. Biotherapeutic products containing multipotent mesenchymal stromal cell (MMSC) secretome may provide new therapeutic paradigm for human healthcare due their immunomodulating regenerative abilities. content capacity depends on...
The aim of the investigation was to assess possibilities application polymer matrix made from Reperen material for closing open wound surface on mucous membrane oral cavity.Materials and Methods.Experimental carried out 15 Chinchilla rabbits.Half created defect hard palate healed under matrix, other half by secondary intention.The results histological cytological examination were assessed day 3, 5, 7.Results.The area granulation connective tissue in specimens mucosa, healing without 5...
The aim of the investigation is to assess influence salt load on atrial (ANP) and brain (BNP) natriuretic peptide production in granules secretory cardiomyocytes rats. Materials Methods.The experiments were carried out 14 white out-bred male Wistar rats weighing 280-300 g.During experiment all animals treated with standard-feed diet had unlimited access food water.NaCl solution was introduced per os dose 1 g kg body mass during days.Arterial pressure (AP) measured noninvasively using a...
The aim of the investigation was to study effect glial cell line-derived neurotrophic factor (GDNF) on animals' resistance cerebral-ischemia-induced damage.Materials and Methods.In vivo studies were carried out C3H male mice weighing 18-40 g.Ischemia modeling performed by bilateral irreversible occlusion both carotid arteries.A neurological status as well an orientative-exploratory behavior experimental animals their learning capability in post-ischemic period analyzed using "Open field"...
The aim of the investigation was to study in experiment total toxicity and immunological safety a novel domestic therapeutic vaccine against recurrent respiratory papillomatosis anogenital condylomatosis, injected intramuscularly.Materials Methods.we studied acute by following parameters: clinical presentation intoxication, median lethal dose size, change body weight surviving animals; chronic -by dynamics general condition animals, weight, hematological biochemical indices peripheral blood,...
Acute lung injury (ALI) as a model of acute respiratory distress syndrome is characterized by inflammation, complex coagulation, and hematologic abnormalities which result in the formation fibrin-platelet microthrombi pulmonary vessels with rapid development progressive dysfunction. We hypothesize that nebulized fibrinolytic agent, non-immunogenic staphylokinase (nSta), may be useful for ALI therapy. First, effect nSta (0.2 mg/kg, 1.0 or 2.0 mg/kg) on coagulogram parameters was studied...
The aim of the investigation was to study toxic properties (chronic toxicity, local irritant and sensitizing effects) medical products Hydrogel RS Microgel RS, intended for use in regenerative medicine as implants replacing defects soft bone tissues, treatment deep burns vitro cell culturing when testing medications.Materials Methods.The work carried out on outbred Wistar rats, Chinchilla rabbits, guinea pigs.There investigated chronic effects (GosNIIGenetika, Russia) based recombinant...
The aim of the study was behavioral phenotyping mice homo-and heterozygous for Sip1 gene, which plays an important role in development mammalian cerebral cortex.Materials and Methods.The performed on hetero-and homozygous gene; these animal models were developed using Cre recombination method.At age 20-30 days, all animals exposed to a high-intensity sound identify predisposition audiogenic epilepsy.At two months, males tested their general physical health phenotypes.The tests included...
Low-level laser therapy, or photobiomodulation, utilizes red near-infrared light for the treatment of pathological conditions due to presence intracellular photoacceptors, such as mitochondrial cytochrome c oxidase, that serve intermediates therapeutic effects. The current study presents an in-detail analysis effect low-intensity LED irradiation on respiratory chain brain mitochondria. We tested whether low-level therapy at 650 nm could alleviate dysfunction in model acute hypobaric hypoxia...