A5009263302- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiomyopathy and Myosin Studies
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Cardiac pacing and defibrillation studies
- Cardiovascular and exercise physiology
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Healthcare Systems and Public Health
- Renin-Angiotensin System Studies
- Neurological Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Protease and Inhibitor Mechanisms
- Metabolism and Genetic Disorders
- Cardiovascular Effects of Exercise
- Mast cells and histamine
- Heart Rate Variability and Autonomic Control
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bryophyte Studies and Records
- Tryptophan and brain disorders
- Long-Term Effects of COVID-19
- Viral Infections and Immunology Research
- Cancer Treatment and Pharmacology
Sechenov University
2016-2025
Kazan Federal University
2017-2024
Research Institute of Emergency Care
2023
Ryazan State Medical University named after Academician I.P. Pavlov
2021
University of Surrey
2021
Bauman Moscow State Technical University
2016
Obesity is one of the leading and most serious risk factors cardiovascular diseases. Overweight provokes many metabolic hemodynamic disorders. About 30% inhabitants planet have overweight prevalence obesity increases by 10% every 10 years according to WHO data. The probability arterial hypertension in obese patients 50% higher than people with normal body mass. Framingham study showed that an independent, significant factor ischemic heart disease, myocardial infarction, cerebral stroke...
Abstract Cardiovascular disease (CVD) represents one of the main causes mortality worldwide and nearly a half it is related to ischemic heart (IHD). The article comprehensive study on diagnostics IHD through targeted metabolomic profiling machine learning techniques. A total 112 subjects were enrolled in study, consisting 76 patients 36 non-CVD subjects. Metabolomic was conducted, involving quantitative analysis 87 endogenous metabolites plasma. novel regression method age-adjustment...
Heart failure (HF) is the ending of practically all cardiovascular diseases and reason for hospitalization 49% patients in a cardiological hospital. Available instrumental diagnostic methods biomarkers not always allow verification HF, particularly with preserved left ventricular ejection fraction. Prediction chronic HF risk factors faces great difficulties. Currently, natriuretic peptides (NUP) are widely used diagnosis, prognosis management included clinical guidelines diagnosis treatment...
The diagnosis of heart failure with preserved ejection fraction (HFpEF) remains challenging. use metabolomics approaches seems promising in speeding up and simplifying the diagnostic process HFpEF patients, which can lead to earlier treatment initiation better improvement patient condition. aim this study was develop a panel metabolites (metabolomic biomarkers) for detection HF fraction. included 76 participants hypertension, 36 whom were diagnosed HFpEF. blood plasma metabolomic profile,...
Abstract Classifying heart failure (HF) by stages and ejection fraction (EF) remains a debated topic in cardiology. Metabolomic profiling (MP) offers means to identify unique pathophysiological changes across different phenotypes, presenting promising approach for the diagnosis prognosis of HF, as well development targeted therapies. In our study, MP was performed on 408 HF patients (54.9% male). The mean ages were 62 [53;68], 67 [65;74], 68 [61;72], 69 [65;73] years A, B, C, D,...
<sec> <title>BACKGROUND</title> The main strategy for the management of heart failure (HF) patients with reduced ejection fraction is guideline-directed medical therapy (GDMT). Remote GDMT optimization using digital monitoring and guideline support appears to be a promising method. Therefore, Contribution Digital Monitoring Improving Effectiveness Treatment in Patients Chronic Heart Failure Reduced Ejection Fraction (BOT-IMPROVE-HF) was conducted. </sec> <title>OBJECTIVE</title> aim study...
Objective — the main objective of study is to test hypothesis that achieving lower recommended target levels (LRT) blood pressure (BP) in elderly and senile patients with arterial hypertension (HTN) will be no less safe than higher (HRT) BP HTN, which assessed using home measurement data a remote monitoring system for effectiveness safety antihypertensive therapy. Design methods. The expected include 60 aged 65 years older, who randomly assigned LRT or HRT group achievement SBP (according...
Metabolomics is a promising technology for the application of translational medicine to cardiovascular risk. Here, we applied liquid chromatography/tandem mass spectrometry approach explore associations between plasma concentrations amino acids, methylarginines, acylcarnitines, and tryptophan catabolism metabolites cardiometabolic risk factors in patients diagnosed with arterial hypertension (HTA) (n = 61), coronary artery disease (CAD) 48), non-cardiovascular (CVD) individuals 27). In...
Pollen records from Wonder and Ten Mile lakes, located at aititudinal treeline to the north south of Alaska Range respectively, document vegetation history a portion southern Alaskan boreal forest. The new pollen diagrams indicate Betula shrub tundra, preceded Lake by sparse herb which characterized these two areas during latest Wisconsinan times. Populus was in vicinity ca. 10,000 BP, but apparently absent Lake. Picea glauca grew or near 9100 with P. mariana becoming important 7000 BP....
Background: Progressive myocardial remodeling (MR) in chronic heart failure (CHF) leads to aggravation of systolic dysfunction (SD) and clinical manifestations. Identification metabolomic markers these processes may help the search for new therapeutic approaches aimed at achieving reversibility MR improving prognosis patients with CHF. Methods: To determine relationship between plasma acylcarnitine (ACs) levels, parameters characteristics, CHF ischemic etiology (n = 79) coronary disease CHD...
BACKGROUND: Being stimulated by rapid development of communication technologies, telehealth delivery methods have become widespread and potential benefits for diagnosis, treatment, rehabilitation follow-up patients. The article discusses the integration into clinical practice effectiveness digital tool remote monitoring control treatment patients with rheumatoid arthritis. AIM: to evaluate safety, technological features arthritis using a platform. METHODS: prospective non-randomized...
Abstract Background The existing classifications of heart failure (HF) remain a topic debate within the cardiology community. Metabolomic profiling (MP) offers means to define HF phenotypes based on pathophysiological changes, allowing for more precise characterization patient groups with similar clinical profiles. MP may thus aid in refining and offer novel approach phenotyping. Methods was performed 408 patients different stages HF. Patients symptomatic were divided into by left ventricle...
Studying the key mechanisms of cardiovascular diseases has opened new possibilities for pharmacological impact on pathophysiological heart failure (HF). The signaling pathway, nitric oxide – soluble guanylate cyclase cyclic guanosine monophosphate (NJ-sGC-cGMP), provides normal functioning system in healthy people and serves as a potential target medicines HF with reduced ejection fraction (HFrEF). In HFrEF progression, sGC activity decreases due to endothelial dysfunction oxidative stress....
To identify biomarkers, which are most specific for patients with metabolic syndrome (MS) using metabolomic profiling.Metabolomic profiling of MS and comparison their profile the volunteers was performed high-performance liquid chromatography-mass-spectrometry.The differed in several amino acids, including choline, cysteine, serine acylcarnitine group (р<0.05 all comparisons).The metabolites were identified. Increased concentrations a combination acids carnitines can be considered as...