A5102741319- Pharmacological Effects and Toxicity Studies
- Effects and risks of endocrine disrupting chemicals
- Malaria Research and Control
- Estrogen and related hormone effects
- Computational Drug Discovery Methods
- Reproductive System and Pregnancy
- Blood disorders and treatments
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Reproductive Biology and Fertility
- Toxic Organic Pollutants Impact
- Phytochemistry and Bioactive Compounds
- Natural product bioactivities and synthesis
- Heavy Metals in Plants
- Pesticide Residue Analysis and Safety
- Sexual Differentiation and Disorders
- Animal testing and alternatives
- Plant Toxicity and Pharmacological Properties
- Cancer Risks and Factors
- Hepatitis Viruses Studies and Epidemiology
- Phytochemistry and Biological Activities
- Phytochemistry Medicinal Plant Applications
- Chemical Reaction Mechanisms
- Ginkgo biloba and Cashew Applications
- Ethnobotanical and Medicinal Plants Studies
BASF (Germany)
2017-2021
Universidade Federal do Paraná
2012-2019
While in vitro testing is used to identify hazards of chemicals, nominal assay concentrations may misrepresent potential vivo effects and do not provide dose–response data which can be for a risk assessment. We reverse dosimetry compare effect concentrations-to-in doses causing toxic related endocrine disruption. Ten compounds (acetaminophen, bisphenol A, caffeine, 17α-ethinylestradiol, fenarimol, flutamide, genistein, ketoconazole, methyltestosterone, trenbolone) have been tested the yeast...
The adverse outcome pathway (AOP) is a conceptual construct that facilitates organisation and interpretation of mechanistic data representing multiple biological levels deriving from range methodological approaches including
Tropaeolum majus L. (Tropaeolaceae) is a medicinal herb popularly used in Brazil for treatment of inflammatory and cardiovascular diseases. Despite some published data on its efficacy, there are still few toxicological describing the safety this plant. The aim study was to evaluate (anti)estrogenic (anti)androgenic activity hydroethanolic extract obtained from (HETM), as well possible effects uterine contractility. Three experimental protocols were performed, (a) uterotrophic assay, (b)...
In utero exposure to the antivirals acyclovir and ganciclovir has been reported induce gross structural defects in rat offspring. The present study investigated effects of maternal antiviral treatment on gestation day 10 reproductive nonreproductive organs male offspring with a particular focus testes. Vehicle two doses ganciclovir, 75 300 mg/kg, were administered dams. total fractioned into three subcutaneous applications (3 × distilled water, 3 25 100 mg/kg) that at 8:00 a.m., 1:00 p.m.,...
Mild analgesics have been associated with antiandrogenic effects, but there are no such studies on dipyrone, despite its high prevalence of use in many countries. We examined the production steroid hormones human H295R cells after exposure to dipyrone and two metabolites, 4-Methylaminoantipyrine (MAA) 4-Aminoantipyrine (AA), as well fetal testicular testosterone rats following maternal exposure. Androgen agonistic/antagonistic effects were vitro for metabolites Yeast Screen (YAS) assay vivo...
It has been hypothesized that oils containing high levels of omega-3 polyunsaturated fatty acids, such as canola and fish oil, could counteract some the adverse effects induced by phthalates. In present study, influence different oily vehicles on di-butyl phthalate (DBP)-induced testicular toxicity lipid profile was investigated. Pregnant Wistar rats were treated oral gavage from gestation days 13 to 20 with DBP (500 mg/kg/day) diluted in three vehicles: corn, or oil. Male fetuses analyzed...
Although several studies have shown the inhibitory effects of Tropaeolum majus extracts (HETM) on angiotensin‐converting enzyme (ACE) activity, no been carried out during beginning pregnancy, when humoral and hormonal imbalance may affect zygote early embryo transport. This study investigates whether HETM can embryonic development administered one‐cell‐blastocyst period. Pregnant Wistar rats received orally (3, 30, 300 mg/kg/day) from 1st to 7th gestational day. Rats were killed 8th day...
Tropaeolum majus L., popularly known as nasturtium, is a species widely used in the form of infusions and salads. In last years, antihypertensive, diuretic, calcium potassium sparing activities T. preparations were shown. Moreover, no preclinical 90-day oral toxicity studies conducted. Thus, this study evaluated hydroethanolic extract obtained from (HETM) leaves female male mice, rats, rabbits. Swiss mice Wistar rats treated with HETM (75, 375, 750 mg/kg). The doses rabbits (30, 150, 300...