A5089822117- Sarcoma Diagnosis and Treatment
- Management of metastatic bone disease
- Cancer Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Lymphoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Vascular Tumors and Angiosarcomas
- Bone health and treatments
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Infections and Treatments
- Cancer Immunotherapy and Biomarkers
- Pelvic and Acetabular Injuries
- Neuroblastoma Research and Treatments
- Surgical site infection prevention
- Bone and Joint Diseases
- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- Neurofibromatosis and Schwannoma Cases
- Reconstructive Surgery and Microvascular Techniques
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Total Knee Arthroplasty Outcomes
- Nerve injury and regeneration
- Bone fractures and treatments
Johns Hopkins Medicine
2016-2025
Johns Hopkins University
2016-2025
Levin Group (United States)
2018-2025
Johns Hopkins Hospital
2016-2025
University of Baltimore
2020-2024
Northwell Health
2014-2024
Feinstein Institute for Medical Research
2018-2024
Sidney Kimmel Comprehensive Cancer Center
2019-2023
Creative Commons
2023
Memorial Sloan Kettering Cancer Center
2014-2023
The coronavirus disease 2019 (COVID-19) pandemic has prompted rapid restructuring of the health-care system in an effort to stop spread virus and treat patients who are acutely ill with COVID-19, while continuing provide outpatient care for remainder patients. To help control this pandemic, many centers, including total joint arthroplasty clinics, have boosted telemedicine capability would typically be seen person settings. We review key components relevant establishment effective use...
Abstract Ollier disease (OD) and Maffucci syndrome (MS) are characterized by multiple enchondromas. Patients with MS also have benign vascular overgrowths that become malignant in 8.5% of cases. OD is enchondromas, typically unilateral distribution a predilection for the appendicular skeleton. enchondromas bilaterally distributed most Both disorders feature swellings on extremity, deformity around joints, limitations joint mobility, scoliosis, bone shortening, leg‐length discrepancy, gait...
Background Current therapy for osteosarcoma pulmonary metastases (PMs) is ineffective. The mechanisms that prevent successful immunotherapy in are incompletely understood. We investigated the tumor microenvironment of metastatic with goal harnessing immune system as a therapeutic strategy. Methods 66 tissue specimens were analyzed by immunohistochemistry (IHC) and markers digitally quantified. Tumor-infiltrating lymphocytes (TILs) from 25 profiled functional cytometry. Comparative...
Even though virtually all patients with Ewing sarcoma achieve a radiographic complete response, up to 30% of who present localized disease and 90% those metastases experience metastatic recurrence, highlighting the inability identify residual at end therapy. Up 95% sarcomas carry driving EWS-ETS translocation that has an intronic breakpoint is specific each tumor, authors developed system quantitatively detect DNA fragment in patient plasma.The used long-range multiplex polymerase chain...
Clinical trials with immune checkpoint inhibition in sarcomas have demonstrated minimal response. Here, we interrogated the tumor microenvironment (TME) of two contrasting soft-tissue (STS), rhabdomyosarcomas and undifferentiated pleomorphic (UPS), differing genetic underpinnings responses to understand mechanisms that lead response.Utilizing fresh formalin-fixed, paraffin-embedded tissue from patients diagnosed UPS rhabdomyosarcomas, dissected TME by using IHC, flow cytometry, comparative...
PURPOSE To determine whether breast conservation and prolonged neoadjuvant chemotherapy have efficacy in locally advanced cancer (LABC), as measured by survival rate of conservation. MATERIALS AND METHODS Eighty-nine patients with stage III disease were enrolled at the University Michigan (UM) onto a prospective nonrandomized trial. Patients received nine 21-day cycles chemohormonal therapy that consisted doxorubicin 30 mg/m2 cyclophosphamide 750 intravenously on day 1, conjugated estrogens...
Several patient demographic factors, including marital status, have been demonstrated to prognostic significance for survival in extremity soft tissue sarcoma (ESTS). A study population of 12,546 adult patients diagnosed with ESTS from 1991 2010 was identified the SEER database, a large population-based registry, order determine whether overall had changed over this recent 20-year period. The divided into three groups by year diagnosis: 1991-1996, 1997-2003, and 2004-2010. We used...
Metastatic disease is the most important factor in determining survival of sarcoma patients. Since metastasis predominantly hematogenous, we hypothesized that detection and quantification circulating tumor cells (CTCs) could reflect response to therapy risk metastatic relapse. We evaluated presence CTCs using a novel animal model blood patients with high grade sarcomas utilizing CellSieve™ size-based low pressure microfiltration system. Sarcoma were identified based on antibody staining...
Abstract Background Reported rates of the incidence lymph node metastasis in soft tissue sarcoma vary considerably. Many are based on single-institution series and small patient populations. Certain subtypes, including synovial sarcoma, have been associated with a higher risk involvement. Most single centers insufficient numbers patients to assess accurately, but larger national databases may allow more accurate estimation. Questions/purposes We queried large database asked following...
The decision to treat metastatic bone disease (MBD) surgically depends in part on patient life expectancy. We are unaware of an international analysis how expectancy among these patients has changed over time. Therefore, we asked (1) the for treated MBD time, and (2) which, if any, common primary cancer types associated with longer survival after treatment MBD?
Pathologic fracture of the long bones is a common complication bone metastases. Intramedullary nail stabilization can be used prophylactically (for impending fractures) or therapeutically completed to preserve mobility and quality life. However, local disease progression may occur after such treatment, there concern that surgical instrumentation intramedullary itself seed tumor cells along tract, ultimately leading loss structural integrity construct. Identifying factors associated with...
Epithelioid sarcoma (ES) is a rare soft tissue neoplasm with high recurrence rates. Wide surgical resection remains the only potential curative treatment. ES presents most commonly on fingers, hands and forearm, making light-based cancer cell-targeted therapies such as near-infrared photoimmunotherapy (NIR-PIT) that target-specific, but limited penetration depth, suitable for We established CD44 EGFR were overexpressed in patient samples VA-ES-BJ human cell line. NIR-PIT of cells using...
Declining reimbursement rates can lead to decreased access and utilization of common orthopaedic surgeries for patients on Medicare, which is a particularly vulnerable population musculoskeletal injuries. Using the Centers Medicare & Medicaid Services Physician Fee Schedule Look-Up Tool from 2016 2024 data part B beneficiaries 2022, we analyzed trends. Simple linear regressions were executed measure annual trends, Wilcoxon matched-pairs signed rank test used analyze statistical significance...
Case: We present the case of a 15-year-old adolescent boy with recurrent metastatic osteosarcoma to ilium and describe surgical technique iliac wing wide resection allograft reconstruction using custom 3D-printed cutting guide that accounts for complex anatomy by enabling nonlinear osteotomies. Conclusion: Use resect circumferential focus allows targeted lesion removal less morbidity than unguided resection. Importantly, this novel improves ease resecting cylindrical bone segment.
Introduction: Skeletal metastases increase the risk of pathologic fractures, causing functional impairment and pain. Predicting morbidity in patients undergoing surgical fixation for these fractures is challenging due to complexity metastatic disease. The Pathologic Fracture Mortality Index (PFMI) was developed predict 30-day postoperative long bone caused by metastases. External validation necessary clinical use. This study aims evaluate following: (1) How well does PFMI medical, surgical,...
Anemia and abnormal platelet count are common among patients with cancer associated complications after orthopaedic procedures. We studied associations between these conditions morbidity within 30 days surgery for pathologic femur or humerus fracture. retrospectively reviewed data from the National Surgery Quality Improvement Project database 145,030 adults following surgical fixation of a fracture 2010 to 2020. Multivariable logistic regressions compared 30-day mild severe anemia versus...
The goals of orthopaedic treatment for most patients with osseous metastases are to control pain, maintain function, and maximize quality life time at home. aim this study was determine differences in 30-day postoperative morbidity mortality between who underwent prophylactic versus postfracture stabilization metastatic lesions long bones.The American College Surgeons National Surgical Quality Improvement Program database queried fixation (n = 461) or 856) pathologic fractures because bones...
Background Reconstructive surgery is often required following lower extremity soft tissue sarcoma resection. The relationship between the method of plastic reconstruction and postoperative wound healing or functional oncologic outcomes in this patient population poorly understood. Methods We performed a retrospective review on all adult patients that underwent resection sarcomas 1996 2016 at our institution. Results One hundred thirty‐six were identified. Wound complications occurred within...