Remodeling of the extracellular matrix (ECM) is a key aspect myocardial response to biomechanical stress and heart failure. Tissue inhibitors metalloproteinases (TIMPs) regulate ECM turnover through negative regulation (MMPs), which degrade structural proteins. inhibitor 2 unique among TIMPs in activating pro-MMP2 addition inhibiting number MMPs. Given this dual role TIMP2, we investigated whether TIMP2 serves critical disease.Pressure overload by transverse aortic constriction (TAC)...

Wildfires are increasing yearly in number and severity as a part of the evolving climate crisis. These fires significant source air pollution, common driver flares cardiorespiratory disease, including asthma, which is most chronic disease childhood. Poorly controlled asthma leads to societal costs through morbidity, mortality, lost school work time healthcare utilization. This retrospective cohort study set Calgary, Canada evaluates relationship between exacerbations during wildfire smoke...

To examine the relative association between fasting plasma glucose vs post-load (1-h and 2-h) levels based on oral tolerance test in pregnancy large-for-gestational-age hypertensive disorders of outcomes.All live singleton births October 2008 December 2014 Alberta, Canada were included. Gestational diabetes mellitus was diagnosed using Diabetes criteria. Logistic regression models used to values infants after adjusting for maternal characteristics pharmaceutical intervention gestational...

Fetal growth restriction (FGR) greatly increases the risk of perinatal morbidity and mortality is associated with increased uterine artery resistance levels oxidative stress. There are currently no available treatments for this condition. The hypothesis that antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol) would improve function rescue fetal was tested in a mouse model FGR, using endothelial nitric oxide synthase knockout (Nos3(-/-)). Pregnant Nos3(-/-) control C57BL/6J...

The development of childhood non-atopic wheeze is associated with the interplay between early-life gut microbiota trajectories and maturation infant immune system. Rationale Wheezing in common evidence accumulating for role microbiome atopic wheeze. Changes to secretory immunoglobulin A (SIgA) production have been linked disease; however, their connection unknown. Objectives To evaluate relationships trajectories, SIgA, Methods, measurements, main results Early-life microbiota, SIgA child...

Background We examined temporal trends, timing, and frequency, as well adverse neonatal maternal outcomes occurring in the first year postpartum among women experiencing syncope during pregnancy. Methods Results This was a retrospective study of pregnancies between January 1, 2005, December 31, 2014, province Alberta, Canada. Of 481 930 pregnancies, 4667 had an episode syncope. Poisson regression analysis found 5% increase/year (rate ratio, 1.05; 95% CI, 1.04-1.06) age-adjusted incidence...

Polytomous regression models generalize logistic for the case of a categorical outcome variable with more than two distinct categories. These are currently used in clinical research, and it is essential to measure their abilities distinguish between categories outcome. In 2012, van Calster et al proposed polytomous discrimination index (PDI) as an extension binary c‐statistic unordered regression. The PDI summary simultaneous all Previous implementations not capable running on “big data.”...

Key points At rest, dopamine induces recruitment of intrapulmonary arteriovenous anastomoses (IPAVA) and increases venous admixture (i.e. ). Dopamine during exercise, may be partly responsible for exercise‐induced IPAVA recruitment. In this study, we antagonized receptors with metoclopramide, observed improved pulmonary gas exchange but no difference in exercise. blockade decreased cardiac output at peak resulting exercise performance. Increasing endogenous is important the normal healthy...

Patients with asthma are at an increased risk of cardiovascular disease (CVD),1Iribarren C. Tolstykh I.V. Miller M.K. Sobel E. Eisner M.D. Adult and coronary heart disease, cerebrovascular failure: a prospective study 2 matched cohorts.Am J Epidemiol. 2012; 176: 1014-1024Crossref PubMed Scopus (21) Google Scholar systemic inflammation associated may play role. High levels the proinflammatory cytokines IL-6, C-reactive protein, tumor necrosis factor-alpha elevated in asthma, all CVD...

Preventing poor childhood asthma control is crucial for short-term and long-term respiratory health. This study evaluated associations between perinatal early-life factors early control.This retrospective used administrative health data from mothers children born 2010-2012 with a diagnosis of before age 5 years, in Alberta, Canada. The outcome was within 2 years after diagnosis. Associations risk partly uncontrolled were by multinomial logistic regression.Of 7206 preschoolers asthma, 52% had...

Dyspnea has been reported to be a main contributor exercise avoidance in asthma. While traditional markers of ventilation do not explain the heightened dyspnea during patients with asthma, this study proposed that exertional asthma was due high-operating lung volumes, which may improved short-acting β2-agonist. On two separate days, 16 and controls completed function test incremental tests exhaustion. one days (order randomized), 400 µg salbutamol administered before exercise. Inspiratory...

Some patients with chronic obstructive pulmonary disease (COPD) fail to achieve health benefits rehabilitation (PR). Exercise intensity and load represent stimulus for adaptation but it is unclear whether inappropriate exercise and/or are affected by severity of COPD, which may affect benefits. The purpose was determine COPD the limitation (PLE) impacted exercising or resultant intensity/load outcomes derived from PR.Patients (n = 58, age 67 ± 7 y, forced expiratory volume in first second...

Heightened arterial stiffness is a marker of cardiovascular risk and elevated in chronic obstructive pulmonary disease (COPD). Physical activity has been shown to reduce stiffness, our previous work that related physical exercise tolerance COPD. The purpose this study was evaluate whether baseline influence the benefits associated with standard COPD outpatient rehabilitation (PR).A total 66 patients were recruited from G.F. MacDonald Centre for Lung Health, Edmonton, Alberta, prior entering...

Social determinants of health (SDH) may influence children's weight status. Our objective was to examine relationships between SDH and preschoolers' status.This retrospective cohort study included 169 465 children (aged 4-6 years) with anthropometric measurements taken at immunization visits from 2009 2017 in Edmonton Calgary, Canada. Children were categorized by status based on WHO criteria. Maternal data linked child data. The Pampalon Material Deprivation Indexes used assess deprivation....

IntroductionAsthma is associated with increased risk of cardiovascular diseases. Despite many presenting symptoms asthma, asthma cannot always be confirmed by physiological assessment. It thus far unknown if the heightened applies to this group. The purpose study was examine markers risk, including endothelial function, arterial stiffness, and systemic inflammation, in individuals unconfirmed healthy controls. As short-acting beta agonist (SABA) use a secondary analysis conducted investigate...

Recent work demonstrates that carotid chemoreceptor (CC) activity/sensitivity is elevated in patients with chronic obstructive pulmonary disease (COPD) compared healthy controls, and this chemoreception appears to contribute increased cardiovascular risk. Exercise training has been shown normalize CC other populations, therefore, the purpose of study was determine whether rehabilitation (PR) can reduce COPD. Forty-five COPD [mean FEV1 (forced expiratory volume 1 s) = 56.6% predicted]...

Assisted human reproduction (AHR) can be used to help individuals and couples overcome infertility issues. We sought describe trends in pregnancies using AHR evaluate the impact of on perinatal outcomes a large population-based cohort Alberta, Canada.We linked maternal child administrative data for all live births occurring July 1, 2009, Dec. 31, 2018, Canada, this retrospective study. identified from pharmaceutical claims or codes International Classification Diseases Related Health...

Background People experiencing asthma exacerbations are at increased risk of cardiovascular events. To better understand the relationship between and risk, this randomized case-control, cross-over controlled trial assessed immediate systemic inflammatory vascular responses to acutely induced pulmonary inflammation bronchoconstriction in people with controls. Methods Twenty-six 25 controls underwent three airway challenges (placebo, mannitol, methacholine) random order. Markers including...

Journal Article Clean air shelters: A climate-adaptive measure to protect children's respiratory health during wildfire events Get access Tori Wright, MPH, MPH School of Public Health, College Health Sciences, University Alberta, Edmonton, Canada Search for other works by this author on: Oxford Academic Google Scholar Linn E Moore, PhD, PhD Department Pediatrics, Faculty Medicine and Dentistry, https://orcid.org/0000-0003-0451-460X Anne Hicks, MD FRCP(C) MSc Correspondence: 4-590 Edmonton...

Individuals with asthma breathe at higher operating lung volumes during exercise compared healthy individuals, which contributes to increased exertional dyspnoea. In health, females are more likely develop dyspnoea than males a given workload or ventilation, and therefore, it is possible that may disproportional on exertion. The purpose of this study was compare volume responses in without asthma.