A5089303330- Advanced MRI Techniques and Applications
- Thermoregulation and physiological responses
- Venous Thromboembolism Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- Cardiovascular Disease and Adiposity
- Atomic and Subatomic Physics Research
- Cardiac Imaging and Diagnostics
- Renal and Vascular Pathologies
- Infrared Thermography in Medicine
- Thermal Regulation in Medicine
- Cardiovascular Health and Disease Prevention
- Functional Brain Connectivity Studies
- Blood Coagulation and Thrombosis Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Aortic aneurysm repair treatments
- Peripheral Artery Disease Management
- Climate Change and Health Impacts
- Medical Imaging Techniques and Applications
- Cardiovascular Function and Risk Factors
- Ultrasound and Hyperthermia Applications
University of Michigan
2017-2020
East Carolina University
2012
Although widely used as a preclinical model for studying venous diseases, there is scarcity of in vivo characterizations the naïve murine system. Additionally, previous studies on veins (ex vivo) have not included influence surrounding structures and biomechanical forces. Using MRI, we noninvasively quantified cross-sectional area, cyclic strain, circularity system young old, male female C57BL/6 mice. We investigated most common locations to perform disease research: jugular vein, suprarenal...
Purpose: The cardiovascular (CV) system plays a vital role in thermoregulation. To date, the response of core vasculature to increasing temperature has not been adequately studied vivo. Our objective was non-invasively quantify arterial murine models due increases body temperature, with focus on vessels torso and investigate whether responses were dependent sex or age.Methods: Male female, adult aged mice anaesthetised underwent magnetic resonance imaging (MRI). Data acquired from circle...
Background One of the primary biomechanical factors influencing arterial health is their deformation across cardiac cycle, or cyclic strain, which often associated with stiffness. Deleterious changes in cardiovascular system, e.g., increased stiffness, can remain undetected until system challenged, such as under a stressor like dobutamine. Purpose To quantify strain mice at different locations along tree prior to and during dobutamine infusion, while evaluating effects sex age. Study Type...
Purpose Oscillating steady‐state imaging (OSSI) is an SNR‐efficient sequence with sensitivity suitable for FMRI. Due to the frequency of signal, respiration‐ and drift‐induced field changes can create unwanted signal fluctuations. This study aims address this issue by developing retrospective correction methods that utilize OSSI properties denoise task‐based FMRI experiments. Methods A denoising approach was developed leverages unique perform without a manually specified noise region...
Intracranial aneurysms affect thousands of people every year, therefore the ability to monitor their growth or predict rupture would be invaluable for planning treatment. One proposed method address this issue predicting is use computational fluid dynamics (CFD) based on phase contrast magnetic resonance (PC-MR). CFD and PCMR have been used understand some fundamental conditions cerebrovascular flow. While there has general acceptance validity CFD, research suggests that can poor correlation...
Therapeutic angiogenesis is pertinent to the acute survival of distal ischemic tissue and a relevant treatment for critical limb ischemia (CLI). arteriogeneis restoration function, via collateral vessel formation in proximal that not typically ischemic, preventing intermittent claudication from advancing CLI. In preclinical models peripheral artery disease (PAD), laser perfusion imaging methods are applicable former. However, recently published results indicate they underestimate recovery...