A5042508709- Nonmelanoma Skin Cancer Studies
- Dermatologic Treatments and Research
- Skin Protection and Aging
- Photodynamic Therapy Research Studies
- Infectious Diseases and Mycology
- Vascular Malformations and Hemangiomas
- Cutaneous Melanoma Detection and Management
- Acne and Rosacea Treatments and Effects
- melanin and skin pigmentation
- Facial Rejuvenation and Surgery Techniques
- Cancer and Skin Lesions
- Vascular Tumors and Angiosarcomas
- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Cutaneous lymphoproliferative disorders research
- Soft tissue tumors and treatment
- Wound Healing and Treatments
- Oral Health Pathology and Treatment
- Hedgehog Signaling Pathway Studies
- Genetic and rare skin diseases.
- Body Image and Dysmorphia Studies
- Laser Applications in Dentistry and Medicine
- Porphyrin Metabolism and Disorders
- Trypanosoma species research and implications
- Diagnosis and Treatment of Venous Diseases
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2014-2025
Universidade de São Paulo
2000-2023
Faculty (United Kingdom)
2013
Universidade Brasil
2009
The field cancerization concept in photodamaged patients suggests that the entire sun-exposed surface of skin has an increased risk for development (pre)-malignant lesions, mainly epithelial tumours. Topical photodynamic therapy (PDT) is a noninvasive therapeutic method multiple actinic keratosis (AK) with excellent outcome.To evaluate clinical, histological and immunohistochemical changes human after sessions PDT methyl-aminolaevulinate (MAL).Twenty-six AK on face received three consecutive...
Topical photodynamic therapy (PDT) is an approved treatment for superficial nonmelanoma skin cancers. To enhance photosensitizer penetration into the epidermis, microneedling (MN) devices or ablative carbon dioxide lasers are combined with PDT.To compare efficacy and safety of MN-assisted PDT that conventional in human field cancerization.Ten patients multiple actinic keratoses (AKs) photodamage were randomized to receive methyl aminolevulinate (MAL) previous gentle curettage on one side...
Melasma is a frequent and difficult to treat skin disorder. Results of laser therapy are inconsistent.To determine the safety efficacy low-fluence Q-switched neodymium-doped yttrium aluminum garnet (QS Nd:YAG) for melasma treatment assess recurrence rates histopathologic findings before after treatment.Twenty patients were treated with 10 weekly sessions 1064-nm QS Nd:YAG at 1-week intervals. The modified Area Severity Index (mMASI) score was evaluated baseline; 1 week; 1, 3, 6 months...
Hypertrophic scars are common problems and represent a challenging condition to treat. Fractional photothermolysis has been effective at resurfacing photodamaged skin, acne scars, atrophic but there few reports on its use for hypertrophic scars.To evaluate the safety efficacy of 1,550-nm erbium-doped fiber laser treatment in eight patients.Eight patients (skin phototypes II-IV) with received monthly treatments laser. Energy settings ranged from 35 50 mJ, 10 passes were applied levels 6 8. An...
BackgroundTopical photodynamic therapy (PDT) is an approved treatment for actinic keratosis (AK). To enhance the efficacy of PDT AKs, physical and chemical pretreatments have been suggested.
Summary Introduction Actinic cheilitis ( AC ) is a lip intraepithelial neoplasia, whose cells present alterations similar to those presented by invasive squamous cell carcinomas SCC s). Objective To conduct clinical and laboratory evaluation histopathology immunohistochemistry of the efficacy actinic treatment using photodynamic therapy PDT with methyl aminolevulinate MAL noncoherent red light. Materials methods Patients detected histopathological examination were submitted two sessions...
A practical and up-to-date consensus among experts is paramount to further improve patient care in actinic keratosis (AK).To develop a structured statement on the diagnosis, classification, management of AK based information.A systematic review clinical guidelines was conducted. This informed preparation 3-round Delphi procedure followed by meeting, which combined opinions 16 from 13 countries, construct treatment algorithm positioning daylight photodynamic therapy (dl-PDT) other options.The...
A terapia fotodinâmica envolve a administração de uma droga fotossensibilizante e sua ativação subsequente pela luz comprimento onda correspondente ao espectro absorção do fotossensibilizador. Atualmente, tópica é aprovada para o tratamento condições oncológicas cutâneas como queratoses actínicas, doença Bowen carcinoma basocelular superficial em diversos países mundo. Estudos multicêntricos controlados randomizados demonstram alta eficácia resultado cosmético final superior dessa modalidade...
Five per cent 5-fluorouracil (5-FU) cream is a well-established treatment for actinic keratosis (AK), and ingenol mebutate gel (IMB) novel topical field-directed therapy.To compare the tolerability safety of IMB with that 5-FU facial AK.An open-label, prospective, randomized, controlled clinical trial 100 patients AKs within 25-cm(2) contiguous field on face was conducted. applied daily three consecutive days. twice day 4 weeks. The effect adverse events were evaluated at baseline days 2, 3,...
Abstract Background Mutations in kinetochore gene KNSTRN accelerate the development of cutaneous squamous cell carcinoma ( SCC ) and may correlate with different histological classifications actinic keratosis AK s). Objective To determine mutation frequency healthy skin HS ), actinically damaged ADS s histomorphological gradings invasive s. Methods All samples were histologically evaluated. lesions additionally classified according to their upwards I– III downwards PRO directed growth...
Summary Background Daylight‐mediated photodynamic therapy ( DL ‐ PDT ) is an efficacious treatment option for thin actinic keratosis AK that offers advantages over conventional in terms of tolerability, duration, and cost. A clinical study conducted Australia determined the mean irradiance during a 2‐hour exposure to be 305.8 W/m 2 (range: 40–585 ). The protoporphyrin IX light dose influenced by latitude, weather conditions, time year. recent meteorological data concluded can performed...
To enhance the efficacy of photodynamic therapy (PDT) for actinic keratosis (AKs), physical and chemical pre-treatments, such as calcipotriol (CAL) have been suggested. compare long-term 12-month safety between methylaminolevulinate (MAL)-PDT prior application topical CAL versus conventional MAL-PDT AKs scalp. Twenty patients with multiple on scalp were randomized to receive PDT one side CAL-assisted PDT, in which was applied daily 15 days beforehand, other side. Patients evaluated AK...
Background. Skin resurfacing with CO2 laser is a common surgical procedure to improve photodamaged skin. Many complications may occur after this procedure, however, warts relatively rare. Objective. To report case of multiple and discuss the complete involution these lesions. Methods. A 78-year-old woman described. Results. The patient developed on face laser. Retinoic acid was introduced lesions observed 5 days no scars. Conclusion. Although emphasis placed hazards plume medical staff, one...