A5030659376- Nanoparticle-Based Drug Delivery
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Prostate Cancer Treatment and Research
- Nanoplatforms for cancer theranostics
- Curcumin's Biomedical Applications
- Synthesis of Organic Compounds
- Synthesis and biological activity
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Photodynamic Therapy Research Studies
- X-ray Diffraction in Crystallography
- RNA Interference and Gene Delivery
- Electrochemical Analysis and Applications
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Synthesis and Reactions of Organic Compounds
- Phytochemistry and Biological Activities
- Estrogen and related hormone effects
- Molecular Sensors and Ion Detection
- Natural product bioactivities and synthesis
- Weed Control and Herbicide Applications
- Quinazolinone synthesis and applications
Changzhou University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Sun Yat-sen University
2024
Johns Hopkins University
2024
Stomatology Hospital
2024
Peking Union Medical College Hospital
2024
University of Jinan
2022-2023
Lund University
2018
Changzhou Vocational Institute of Light Industry
2018
Jiangsu University of Technology
2018
Early studies suggested androgen receptor (AR) splice variants might contribute to the progression of prostate cancer (PCa) into castration resistance. However, therapeutic strategy target these AR still remains unresolved. Through tissue survey tumors from same patients before and after resistance, we found that expression AR3, a major variant lacks ligand-binding domain, was substantially increased resistance development. The currently used antiandrogen, Casodex, showed little growth...
Much fewer mice lacking androgen receptor (AR) in the entire body develop bladder cancer (BCa). However, role of urothelial AR (Uro-AR) BCa development remains unclear. In present study, we generated that lacked only Uro-AR (Uro-AR(-/y)) to by using carcinogen BBN [N-butyl-N-(4-hydroxybutyl)-nitrosamine] and found Uro-AR(-/y) had a lower incidence higher survival rate than did their wild-type (WT; Uro-AR(+/y)) littermates. vitro assay also demonstrated facilitates neoplastic transformation...
The effects of the flavonoid compound, kaempferol, which is an inhibitor cancer cell proliferation and inducer apoptosis have been shown in various cancers, including lung, pancreatic, ovarian, but its effect has never studied bladder cancer. Here, we investigated kaempferol on using multiple vitro lines vivo mice studies. MTT assay results showed that enhanced cytotoxicity. In contrast, when analyzed by flow cytometric analysis, DNA ladder experiment, TUNEL assay, significantly was to...
Abstract Early studies suggested macrophages might play roles in inflammation-associated benign prostatic hyperplasia (BPH) development, yet the underlying mechanisms remain unclear. Here we first showed that CD68+ were identified both epithelium and stromal area of human BPH tissues. We then established an vitro co-culture model with prostate epithelial macrophage cell lines to study potential impacts infiltrating development found co-culturing cells promoted migration macrophages. In a...
Morinda officinalis oligosaccharides have been reported to exert neuroprotective and antidepressant-like effects in the forced swim test mice. However, mechanisms that underlie of are unclear. Chronic unpredictable stress were used explore resilience rats. The phosphoinositide-3 kinase inhibitor LY294002 was microinjected medial prefrontal cortex role glycogen synthase kinase-3β oligosaccharides. expression brain-derived neurotrophic factor, phosphorylated-Ser9-glycogen 3β, β-catenin,...
One of the main challenges in cancer therapy is poor water solubility many anticancer drugs which results low bioavailability at tumour sites and reduced efficacy. The currently available polymer-based drug delivery systems often suffer from encapsulation efficiency, uncontrolled release, lack long-term stability. Herein, we report development novel stiffness-tuneable core–shell nanocarriers composed naturally derived polymers silk fibroin (SF) sodium alginate (SA) inside a liposomal shell...
Androgen receptor has a critical role in prostate cancer development and progression. Cell death via autophagy may also contribute to We determined the regulatory effects of androgen on process cells.Using series morphological approaches, such as transmission electron microscopy, monodansylcadaverine (Sigma®) GFP-LC3 fluorescence microscopy assay, Western blot we monitored autophagic 3 pairs cell lines study relationship signals.Androgen knockdown positive cells, LNCaP or CWRrv1 human led...
Chemo-photodynamic therapy shows great potential for cancer treatment. However, the rational integration of chemotherapeutic agents and photosensitizers to construct an intelligent nanoplatform with synergistic therapeutic effect is still a challenge. In this work, curcumin-loaded reduction-responsive prodrug nanoparticles new indocyanine green ([email protected]) were developed chemo-photodynamic therapy. [email protected] exhibit high drug loading content special worm-like morphology,...
Abstract Paclitaxel (PTX) is a chemotherapeutic agent which shows antitumor activities against broad spectrum of cancers. Yet, the current formulation PTX used in clinic may cause number adverse reactions, significantly limit its application. To obtain better clinical use PTX, we report, for first time, iRGD‐PTX conjugate nanoparticles (NPs) targeted delivery. was synthesized from thiolated iRGD and 6‐maleimidocaproic acid‐PTX through Michael addition reaction. NPs with hydrodynamic diameter...
Dimethylcurcumin (DMC) is a derivative of curcumin. Studies have shown that DMC can enhance the degradation androgen receptors (AR), thereby inhibiting AR-related diseases. However, extremely poor water solubility and fast metabolism in vivo greatly limit its clinical applications. In present study, liposomes loaded with were prepared by an improved membrane hydration method. The formulation was modified to obtain DMC-liposomes particle size between 110 150 nm, moderate encapsulation...
Dimethylcurcumin (ASC-J9) is an organic active pharmaceutical ingredient with anti-inflammatory, antioxidant, and antitumor effects. However, its application has been significantly hindered by poor solubility in aqueous solutions, a short vivo half-life, low bioavailability after oral administration, limited accumulation absorption target areas. Nano-drug delivery systems can serve as drug carriers to enhance delivery, addressing these challenges improved efficacy reduced adverse In this...