A5044735476- Heart Failure Treatment and Management
- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Cardiovascular Function and Risk Factors
- High-Energy Particle Collisions Research
- Nuclear physics research studies
- Pregnancy and preeclampsia studies
- Cardiac Fibrosis and Remodeling
- Cardiac electrophysiology and arrhythmias
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Hormonal Regulation and Hypertension
- Cardiovascular Effects of Exercise
- Adipose Tissue and Metabolism
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Pulmonary Hypertension Research and Treatments
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Atrial Fibrillation Management and Outcomes
- Dialysis and Renal Disease Management
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Ischemia and Reperfusion
- Cardiovascular Issues in Pregnancy
Nara Medical University
2015-2024
Rutgers, The State University of New Jersey
2020-2024
Rutgers New Jersey Medical School
2020-2024
Nara Medical University Hospital
2014-2023
Osaka University
2015-2022
Amyloidosis Foundation
2021
Research Network (United States)
2021
Japan Atomic Energy Agency
2021
National Cerebral and Cardiovascular Center
2011-2015
Nara University
2014
The heart utilizes multiple adaptive mechanisms to maintain pump function. Compensatory cardiac hypertrophy reduces wall stress and oxygen consumption, thereby protecting the against acute blood pressure elevation. nuclear effector of Hippo pathway, Yes-associated protein 1 (YAP), is activated mediates compensatory in response overload (PO). In this study, YAP promoted glycolysis by upregulating glucose transporter (GLUT1), which turn caused accumulation intermediates metabolites glycolytic,...
The energy spacing of the spin-doublet states in ${}_{\mathrm{\ensuremath{\Lambda}}}^{4}$He hypernucleus indicate a large spin dependent charge symmetry breaking $\mathrm{\ensuremath{\Lambda}}\phantom{\rule{0}{0ex}}N$ interaction.
In an emulsion-counter hybrid experiment performed at J-PARC, a $Ξ^-$ absorption event was observed which decayed into twin single-$Λ$ hypernuclei. Kinematic calculations enabled unique identification of the reaction process as $Ξ^{-} + ^{14}$N$\ \rightarrow\ ^{10}_Λ$Be $^5_Λ$He. For binding energy $Ξ^{-}$ hyperon in $Ξ^-$-$^{14}$N system value $1.27 \pm 0.21$ MeV deduced. The level is likely nuclear $1p$ state indicates weak $ΞN$-$ΛΛ$ coupling.
Well-controlled mitochondrial homeostasis, including a mitochondria-specific form of autophagy (hereafter referred to as mitophagy), is essential for maintaining cardiac function. The molecular mechanism mediating mitophagy during pressure overload (PO) poorly understood. We have shown previously that in the heart mediated primarily by Atg5/Atg7-independent mechanisms, Unc-51-like kinase 1 (Ulk1)-dependent alternative mitophagy, myocardial ischaemia. Here, we investigated role PO-induced hypertrophy.
Heart failure (HF) with preserved ejection fraction (HFpEF) is a complex syndrome poor prognosis. Phenotyping required to identify subtype-dependent treatment strategies. Phenotypes of Japanese HFpEF patients are not fully elucidated, whose obesity much less than Western patients. This study aimed reveal model-based phenomapping using unsupervised machine learning (ML) for in
Fibrosis is a hallmark of heart disease independent etiology and thought to contribute impaired cardiac dysfunction development failure. However, the underlying mechanisms that regulate differentiation fibroblasts myofibroblasts fibrotic responses remain incompletely defined. As result, effective treatments mitigate excessive fibrosis are lacking. We recently demonstrated Hippo pathway effector Yes-associated protein (YAP) an important mediator myofibroblast in infarcted heart. Yet, whether...
A double-$\Lambda$ hypernucleus, ${}_{\Lambda\Lambda}\mathrm{Be}$, was observed by the J-PARC E07 collaboration in nuclear emulsions tagged $(K^{-},K^{+})$ reaction. This event interpreted as a production and decay of $ {}_{\Lambda\Lambda}^{\;10}\mathrm{Be}$, ${}_{\Lambda\Lambda}^{\;11}\mathrm{Be}$, or ${}_{\Lambda\Lambda}^{\;12}\mathrm{Be}^{*}$ via $\Xi^{-}$ capture ${}^{16}\mathrm{O}$. By assuming atomic 3D state, binding energy two $\Lambda$ hyperons$\,$($B_{\Lambda\Lambda}$) these...
Abstract Aims A diet with modified components, such as a ketogenic low-carbohydrate (LC) diet, potentially extends longevity and healthspan. However, how an LC impacts on cardiac pathology during haemodynamic stress remains elusive. This study evaluated the effects of high in either fat (Fat-LC) or protein (Pro-LC) mouse model chronic hypertensive remodelling. Methods results Wild-type mice were subjected to transverse aortic constriction, followed by feeding Fat-LC, Pro-LC,...
The differential cross sections of the Σ^{-}p→Λn reaction were measured accurately for Σ^{-} momentum (p_{Σ}) ranging from 470 to 650 MeV/c at J-PARC Hadron Experimental Facility. Precise angular information about was obtained first time by detecting approximately 100 events each step Δcosθ=0.1. show a slightly forward-peaking structure in regions. integrated -0.7≤cosθ≤1.0 as 22.5±0.68 [statistical error(stat.)] ±0.65 [systematic error(syst.)] mb and 15.8±0.83(stat)±0.52(syst)...
Accumulating evidence indicates alteration of the β-adrenoceptor (AR), such as desensitization and subtype switching its coupling G protein, plays a role in protection against catecholamine toxicity heart failure. However, human takotsubo syndrome (TTS), which is associated with surge circulating acute phase, there no histologic β-AR alteration. The purpose this study was to investigate involvement signaling mechanism TTS development. Left ventricular (LV) biopsied samples from 26 patients...
In patients with acute decompensated heart failure (ADHF), sex differences considering clinical and pathophysiologic features are not fully understood. We investigated in left ventricular (LV) ejection fraction (LVEF), plasma B-type natriuretic peptide (BNP) levels, prognostic factors ADHF Japan. studied 748 consecutive of 821 registered the registry between January 2007 December 2014. Patients were divided into four groups based on LVEF [reduced (ejection fraction, or EF, <50%, reduced...
Abstract Aims Heart failure (HF) is classified into three types according to left ventricular ejection fraction (EF). The effect of blood pressure (BP) on the pathogenesis each type assumed be different. However, association between prognosis HF and abnormal BP variations assessed by ambulatory monitoring (ABPM), such as nocturnal hypertension riser pattern, remains unclear. Methods results We studied 325 consecutive patients with decompensated who were acutely admitted our hospital...
A high statistics $\mathrm{\ensuremath{\Sigma}}p$ scattering experiment is performed at the J-PARC Hadron Experimental Facility. Momentum-tagged ${\mathrm{\ensuremath{\Sigma}}}^{\ensuremath{-}}\mathrm{s}$ running in a liquid hydrogen target are accumulated by detecting ${\ensuremath{\pi}}^{\ensuremath{-}}p\ensuremath{\rightarrow}{K}^{+}{\mathrm{\ensuremath{\Sigma}}}^{\ensuremath{-}}$ reaction with intensity ${\ensuremath{\pi}}^{\ensuremath{-}}$ beam of 20 M/spill. The differential cross...
Abstract This study aimed to evaluate the prognostic impact and predictors of persistent renal dysfunction in acute kidney injury (AKI) after an emergency percutaneous coronary intervention (PCI) for myocardial infarction (AMI). A total 877 patients who underwent PCI AMI were examined. AKI was defined as serum creatinine (SCr) ≥ 0.3 mg/dL or 50% from baseline within 48 h PCI. Persistent residual impairment SCr 1 month procedure. The primary outcome composite endpoints death, infarction,...
Acute heart failure (AHF) is a clinical syndrome with poor prognosis and major public health concern worldwide. The aim of this study was to investigate whether carperitide administration improves the 1 year patients AHF check there an optimal dose drug.We analysed data COOPERATE-HF-J (the Consortium for Pooled Data Analysis regarding Hospitalized Patients Heart Failure in Japan), combining two cohorts (NARA-HF REALITY-AHF), which included 2435 acute decompensated failure. were divided into...
Background Urinary neutrophil gelatinase‐associated lipocalin (U‐ NGAL ) is an early predictor of acute kidney injury and adverse events in various diseases; however, decompensated heart failure patients, its significance remains poorly understood. This study aimed to investigate the prognostic value U‐ on first day admission for occurrence long‐term outcomes patients. Methods Results We studied 260 patients admitted our department between 2011 2014 by measuring 24‐hour urine samples...
Background Although a tool for sharing patient prognosis among all medical staff is desirable in heart failure (HF) cases, only few simple HF prognostic scores are available. We previously presented the A 2 B score, user‐friendly risk and validated it small single‐center cohort. In present study, we larger nationwide Methods Results examined 2‐year mortality relation to 3483 patients from Japanese cohort attempted stratify their prognoses according scores. The score was determined by...
ABSTRACT Background This study aimed to evaluate the predictive ability of quantifying aortic valve calcification using a virtual (VV) on computed tomography (CT) imaging for perivalvular leak (PVL) following Sapien 3 transcatheter heart implantation. Methods A total 126 patients who underwent implantation were retrospectively analyzed. Patients with left ventricular outflow tract or bicuspid valves excluded. Multiplanar CT reconstructions root VV in position utilized measure calcium volumes...
Abstract Soluble Flt-1 (sFlt-1), an endogenous antagonist of the proatherogenic cytokine placental growth factor, is decreased in chronic kidney disease (CKD), leading to atherosclerotic progression. In this study, we investigated effect AST-120, oral carbon adsorbent which can remove uremic toxins, on sFlt-1 expression levels and atherosclerosis Atherosclerotic apolipoprotein E-deficient mice underwent a 5/6 nephrectomy (5/6 NR) or sham operation (sham) at 8 weeks age were then treated not...
Soluble fms-like tyrosine kinase-1 (sFlt-1), an endogenous inhibitor of vascular endothelial growth factor and placental factor, is involved in the pathogenesis cardiovascular disease. However, significance sFlt-1 heart failure has not been fully elucidated. We found that decreased renal serves as a key molecule atherosclerosis. In this study, we aimed to investigate role production failure, using knockout mice. mice wild-type were subjected transverse aortic constriction evaluated after 7...
Patients who survive acute myocardial infarction (AMI) are at risk of being rehospitalized owing to the occurrence decompensated heart failure (HF). However, clinical characteristics HF after AMI, especially frequency each subtype, unclear.
Mitral annular calcification (MAC) is increasingly observed in elderly population. The purpose of this study was to investigate incidence MAC and its association with mitral valvular disease (MVD).A total 13,483 consecutive patients who underwent echocardiography were enrolled. defined as an echo-dense, shelf-like structure irregular, lumpy appearance involving the valve annulus, acoustic shadowing. Prevalence significant stenosis (MS) or regurgitation (MR) studied. Significant (≥moderate)...
Abstract Iron is an essential trace element in the body. However, heart failure (HF), iron only recognized as cause of anemia. Actually, itself affects myocardial exercise tolerance and cardiac function via mitochondrial function. Therefore, it necessary to clarify pathological significance acute HF, irrespective concomitant We investigated impact serum level at discharge on prognosis 615 patients emergently admitted with decompensated HF (ADHF). Patients were divided into two groups...