A5022654022- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Regulation of Appetite and Obesity
- Adrenal Hormones and Disorders
- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Diabetes Treatment and Management
- Pituitary Gland Disorders and Treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Cardiovascular Function and Risk Factors
- Gestational Diabetes Research and Management
- Health Literacy and Information Accessibility
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Healthcare Systems and Technology
- Social Media in Health Education
- Wastewater Treatment and Nitrogen Removal
- Immune Response and Inflammation
- Spinal Cord Injury Research
- Dietary Effects on Health
- Heme Oxygenase-1 and Carbon Monoxide
Aarhus University
2002-2025
Regionshospitalet Viborg
2015-2025
Aalborg University
2025
Aalborg University Hospital
2025
Aarhus University Hospital
1994-2024
Central Denmark Region
2020-2022
Capital Region of Denmark
2022
Herlev Hospital
2021
Aarhus Municipality
1971-1994
Institute of Economics
1994
High levels of ketone bodies are associated with improved survival as observed regular exercise, caloric restriction, and-most recently-treatment sodium-glucose linked transporter 2 inhibitor antidiabetic drugs. In heart failure, indices body metabolism upregulated, which may improve energy efficiency and increase blood flow in skeletal muscle the kidneys. Nevertheless, it is uncertain how affect myocardial glucose uptake humans. Our study was therefore designed to test whether...
β-hydroxybutyrate (BHB) is recommended as a measure of ketosis and often assessed by capillary samples on point-of-care (POC) meters. However, liquid chromatography tandem mass spectrometry (LC-MS/MS) considered the gold standard for assessing venous samples. The POC device KetoSureTM only from finger pricks. So far, has not been compared to LC-MS/MS just it evaluated if sampling site influences BHB concentration. Blood were collected 16 healthy, fasting individuals before after ingestion...
Background Lipolysis is accelerated during the acute phase of inflammation, a process being regulated by pro-inflammatory cytokines (e.g. TNF-α), stress-hormones, and insulin. The intracellular mechanisms remain elusive we therefore measured pro- anti-lipolytic signaling pathways in adipocytes after vivo endotoxin exposure. Methods Eight healthy, lean, male subjects were investigated using randomized cross over trial with two interventions: i) bolus injection saline (Placebo) ii)...
The appetite-suppressing potential of liver-expressed antimicrobial peptide 2 (LEAP2), and its antagonistic effects on the hunger-inducing hormone ghrelin have attracted scientific interest. It is unclear how LEAP2 influenced by fasting it responds to specific nutrients.The purpose this investigation was assess whether concentration 1) decreases after fasting, 2) increases postprandially, 3) regulated nutrient sensing in splanchnic bed.Plasma measured blood samples from 5 clinical cross-over...
Abstract Context Women with gestational diabetes mellitus (GDM) have an increased risk of long-term complications, including impaired glucose metabolism, type 2 (T2DM), cardiovascular disease, and obesity. In current clinical practice, a 1 size fits all approach to GDM is applied, although heterogeneity among women has been recognized. Objective To give the most adequate preventive care postpartum (PP) guidance, we aimed make metabolic characterization identify subgroups previous within...
Pregnant women are occasionally misdiagnosed with gestational diabetes (GDM) when they may have glucokinase monogenic (GCK-MODY). Differentiating between GCK-MODY and GDM is critical due to the distinct treatment strategies required during after pregnancy. Since pregnancy often elicits first glucose tolerance test, it provides a unique opportunity identify individuals GCK-MODY. However, testing all pregnant for expensive, use of clinical criteria warranted. An Irish study suggested using...
D-3-hydroxybutyrate (D-3-OHB) is a ketone body that serves as an alternative nutritional fuel but also important signaling metabolite. Oral supplements containing D/L-3-OHB are becoming popular approach to achieve ketosis.To explore the gut-derived effects of supplements.Eight healthy lean male volunteers were investigated on 2 separate occasions:An acetaminophen test was performed evaluate gastric emptying and blood samples obtained consecutively throughout study period.We show oral...
To investigate the acute effect of ketone ester (KE) ingestion on appetite and plasma concentrations acyl ghrelin (AG), unacylated (UAG) glucagon-like peptide-1 (GLP-1) secretion, to compare responses with those elicited by isocaloric glucose (GLU) administration.We examined 10 healthy young men three separate occasions using a placebo (PBO)-controlled crossover design. A KE versus taste-matched isovolumetric 50% GLU PBO vehicle was orally administered. Our main outcome measures were AG,...
Biological sludge hydrolysis was demonstrated in full scale at three Danish wastewater treatment plants. For primary the yield expressed terms of filtrable COD varied from 9–16% total (WTPs 1 & 2) and for activated a 2.5% found. The addition hydrolysate to improve biological P removal considerably. No effect on nitrogen could be identified due favourable composition during demonstration phase. A cost-benefit analysis showed that may cost efficient process should considered connection with...
The indication for treatment of type 1 diabetes(T1D) with the sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin has been withdrawn in Europe likely because concern diabetic ketoacidosis (DKA). We calculated incidence DKA people T1D treated SGLT2i Denmark.Clinical data from adults Denmark were collected nine outpatient clinics. Electronic health records made search accurate.From a population 10.500 we observed 134 over total period 222 patient-years. Of those 72% female, mean...
Endotoxin administrations are used in experimental models of inflammatory disease. Short-term endotoxin tolerance response to repeated exposure is well known, but the duration humans remains unknown. The main purpose this study was test whether present vivo when separating exposures with more than 5 weeks, a time span often between individual investigations clinical studies. Seventeen healthy young men were exposed twice Escherichia coli endotoxin. calculated as area under curve first and...
In patients with type 2 diabetes (T2D) and heart failure (HF), the optimal glycemic target is uncertain, evidence-based data are lacking. Therefore, we performed a randomized study on effect of optimized control left ventricular function, exercise capacity, muscle strength, body composition.40 T2D HF (left ejection fraction (LVEF) 35±12% hemoglobin A1c (HbA1c) 8.4±0.7% (68±0.8 mmol/mol)) were to either 4-month optimization (OPT group) or non-optimization (non-OPT control. Patients underwent...
Gastric ulcer haemorrhage is associated with a high immediate mortality, but few data exist on the late prognosis of these patients. The aim this study was to determine long-term recurrence rate and outcome in patients gastric complicated bleeding.In prospective follow-up 90 consecutive bleeding discharged after non-operative treatment (bleeding controlled by endoscopic electrocoagulation or ceased spontaneously) were followed up once every year for 5-8 years (median, 6.5 years).Recurrent...
Soluble CD163 (sCD163) is a novel marker linked to states of low-grade inflammation such as diabetes, obesity, liver disease, and atherosclerosis, all prevalent in subjects with Turner syndrome (TS) Klinefelter (KS). We aimed assess the levels sCD163 regulation regards treatment sex hormone therapy males without KS females TS. Males (n=70) age-matched controls (n=71) participating cross-sectional study 12 healthy from an experimental hypogonadism study. Females TS (n=8) randomized crossover...
Summary Background Hypercortisolism is prevalent in type 2 diabetes (T2D), but analytical and functional uncertainties prevail. Measurement of salivary cortisol considered an expedient screening method for hypercortisolism, its usefulness the context T2D uncertain. Aim To compare late‐night ( LNSC ) with 1 mg overnight dexamethasone suppression test DST ), which was ‘reference standard’, T2D. Patients methods A total 382 unselected recently diagnosed patients underwent assessment , outcome...
Beta-hydroxybuturate (
Adipose tissue physiology and homeostasis depends on a healthy vascular network. Vascular malfunction is hallmark of obesity, endothelial dysfunction, in particular, precipitates metabolic diseases, including obesity type two diabetes. Although single-cell transcriptomics approaches have defined atlases human white adipose (WAT) cells, the associated cells remain relatively undefined. Specifically, there limited information their heterogeneity function, roles disease. To address this gap, we...
Biological sludge hydrolysis was demonstrated in full scale at three Danish wastewater treatment plants. For primary the yield expressed terms of filtrable COD varied from 9–16% total (WTPs 1 & 2) and for activated a 2.5% found. The addition hydrolysate to improve biological P removal considerably. No effect on nitrogen could be identified due favourable composition during demonstration phase. A cost-benefit analysis showed that may cost efficient process should considered connection...
Measurement of β-hydroxybutyrate (BHB) in blood is used clinically as a measure ketosis when diabetic ketoacidosis expected. With the introduction point-of-care testing (POCT) for blood-BHB, nonproductive time reduced to minimum potential critical situation; however, studies have observed inferior quality POCT-BHB. Recently, POCT device KetoSure (Roche) has been introduced clinic. In this study, we evaluated imprecision and linearity compared established StatStrip Express (Nova Biomedical)...
There is a growing focus on the potential uses, benefits, and limitations of social media in context health care communication. In this study, we have sought to evaluate an initiative pioneered at hospital Denmark that uses Facebook support enhance patient-provider communication about diabetes.This paper aims success trial according its initial objectives assess scalability.The study was undertaken clinic for diabetes hormonal diseases large regional Denmark. Using realist evaluation...