A5056827841- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Cardiovascular Function and Risk Factors
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Cardiac Imaging and Diagnostics
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gestational Diabetes Research and Management
- Thyroid Disorders and Treatments
- Skin Diseases and Diabetes
- Endoplasmic Reticulum Stress and Disease
- Heart Failure Treatment and Management
- Adipose Tissue and Metabolism
- Diabetes Management and Education
- Chronic Disease Management Strategies
- Nitric Oxide and Endothelin Effects
- Diabetic Foot Ulcer Assessment and Management
- Sirtuins and Resveratrol in Medicine
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Machine Learning in Healthcare
- Hormonal Regulation and Hypertension
- Iron Metabolism and Disorders
- Dupuytren's Contracture and Treatments
Steno Diabetes Centers
2016-2025
Copenhagen University Hospital
2021-2024
University of Copenhagen
1968-2023
Bispebjerg Hospital
2023
Capital Region of Denmark
2018-2022
Gentofte Hospital
2018-2022
Rigshospitalet
1966-2006
Frederiksberg Hospital
2006
University of Sussex
2000
Herlev Hospital
1989-1999
OBJECTIVE To assess whether intermittent real-time continuous glucose monitoring (CGM) improves glycemic control and pregnancy outcome in unselected women with pregestational diabetes. RESEARCH DESIGN AND METHODS A total of 123 type 1 diabetes 31 2 were randomized to use CGM for 6 days at 8, 12, 21, 27, 33 weeks addition routine care, including self-monitored plasma seven times daily, or care only. optimize control, readings evaluated by a caregiver. HbA1c, glucose, severe hypoglycemia,...
This study was designed to test the hypothesis that target-cell activity influences degree and time course of interleukin 1β (IL-1β)–mediated β-cellimpairment in vitro. Functional morphological studies were performed cultured newborn rat islets Langerhans exposed from 6 h days 50–2000 ng/L recombinant human IL-1β. β-Cell modulated by glucose nonglucose agents (15 mM L-leucine 10 μM long-acting somatostatin analogue SMS 201–995). In 11 glucose, 2000 IL-1β caused inhibition insulin release...
This study investigated the efficacy and safety of once-daily liraglutide 1.2 mg versus placebo as add-on to insulin treatment in normal-weight patients with poorly controlled type 1 diabetes.In a randomized (1:1), double-blind, placebo-controlled design, 40 diabetes (HbA1c ≥8% [64 mmol/mol]) received or for 12 weeks. Continuous glucose monitoring was performed before at end treatment. The primary point change HbA1c. Secondary points included dose, weight, glycemic excursions, heart rate,...
To test the effect of glucagon-like peptide-1 receptor agonist, liraglutide, on residual beta-cell function in adults with newly diagnosed type 1 diabetes.
We tested the hypothesis that elevated transferrin saturation is associated with an increased risk of any form diabetes, as well type 1 or 2 diabetes separately.We used two general population studies, The Copenhagen City Heart Study (CCHS, N = 9,121) and General Population (CGPS, 24,195), a 1:1 age- sex-matched population-based case-control study 6,129 patients from Steno Diabetes Centre control subjects, totaling 8,535 37,039 subjects.In combined odds ratios in those ≥50% vs. <50% were 2.1...
Objectives: We aimed to determine the prevalence of echocardiographic abnormalities and their relation clinical characteristics cardiac symptoms in a large, contemporary cohort patients with type 2 diabetes. Results: A total 1030 diabetes participated. Echocardiographic were present 513 (49.8%) patients, mainly driven by high diastolic dysfunction 178 (19.4%), left ventricular hypertrophy 213 (21.0%) atrial enlargement, 200 (19.6%). The increased markedly age from 31.1% youngest group...
Recurrent hypoglycemia promotes impaired awareness, resulting in an increased risk for asymptomatic hypoglycemia. However, there are no firm data on the frequency of daily life needed to initiate this vicious cycle or role To explore association between hypoglycemic exposure and proportion relation severe Prospective observational trial. Outpatient clinic. One hundred fifty-three unselected patients with type 1 diabetes mellitus (T1D). Six days blinded continuous glucose monitoring recording...
Abstract Aim To investigate the efficacy of adding glucagon‐like peptide‐1 receptor agonist liraglutide to continuous subcutaneous insulin infusion (CSII) in overweight or obese persons with type 1 diabetes and non‐optimal glycaemic control. Materials methods A 26‐week, randomized, double‐blind, placebo‐controlled trial including 44 adults randomized 1:1 1.8 mg once daily (QD) placebo added CSII treatment. The primary endpoint was change haemoglobin A1c (HbA1c). Secondary endpoints included...
Cystic fibrosis (CF)-related diabetes has been regarded as a mild form of with low risk severe complications. The prevalence CF-related increases age, resulting in 50% at age 30 years. We sought to investigate whether microvascular complications appear relevant frequency.Thirty-eight patients aged (range 18-55) years for 20 (0-31) were screened Because chronic pulmonary infections, the majority regularly treated aminoglycoside and cyclosporine given frequently.Since pharmacological treatment...
Nicotinamide (NA) prevents macrophage- and interleukin-1 (IL-1)-mediated β-cell damage in vitro as well diabetes development animal models of insulin-dependent mellitus (IDDM). IL-1 β-mediated inhibition insulin release to β-cells are associated with intracellular production nitric oxide (NO) radicals. Therefore, we studied whether NA prevented β-induced islet NO production, measured nitrite from isolated rat islets, and, if so, this action was prevention release. dose- time-dependently...
To explore insulin pump settings in a cohort of pregnant women with type 1 diabetes on therapy bolus calculator.Twenty-seven were included this study. At 8, 12, 21, 27 and 33 weeks, HbA1c recorded. Results compared 96 multiple daily injection therapy.Throughout pregnancy, the carbohydrate-to-insulin ratio decreased at all three main meals. The most pronounced decrease was observed breakfast, where reduced, from median 12 (range 4-20) early pregnancy to 3 (2-10) g carbohydrate per unit late...
OBJECTIVE This study aimed to investigate the association between continuous glucose monitoring (CGM)-derived glycemic metrics and different insulin treatment modalities using real-world data. RESEARCH DESIGN AND METHODS A cross-sectional at Steno Diabetes Center Copenhagen, Denmark, included individuals with type 1 diabetes CGM. Data from September 2021 August 2022 were analyzed if CGM was used for least 20% of a 4-week period. Individuals divided into four groups: multiple daily injection...
The intracellular molecular events involved in the β-cell death process are complex but poorly understood. Cytokines, e.g., interleukin (IL)-1β, may play a crucial role inducing this process. Protein synthesis is necessary for deleterious effect of IL-1, and induction both protective proteins has been described. To characterize rather pattern islet protein expression rat islets response to we have attempted identify altered level after IL-1 exposure by 2D gel electrophoresis mass...
Diabet. Med. 29, 272–277 (2012) Abstract Aim To evaluate self‐reported satisfaction and barriers to initiating real‐time continuous glucose monitoring in early pregnancy among women with pregestational diabetes. Methods Fifty‐four Type 1 diabetes 14 2 were offered for 6 days at median 9 (range 6–14) gestational weeks asked answer a semi‐structured questionnaire on patient satisfaction. Results Median HbA 1c was 49 34–86) mmol/mol) [6.6 (5.3–10.0) %] duration of 12 (0.5–37) years. Continuous...
Glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy is a potential treatment as adjunct to insulin in type 1 diabetes (T1D). However, GLP-1RAs inhibit glucagon secretion and delay the gastric emptying (GE) rate may impair recovery from hypoglycaemia. We evaluated effect of GLP-1RA liraglutide on counterregulatory responses GE during hypoglycaemia persons with T1D.In 12-week, randomized, double-blind, placebo-controlled study, 20 patients aged >18 years T1D HbA1c ≥8% (64 mmol/mol) were...
AimTo validate the Type 1 Diabetes Distress Scale (T1-DDS) in a large sample of adults with diabetes (T1D) from clinics Denmark.MethodsAltogether 40 T1D were interviewed to explore content T1-DDS Danish setting and translation into Danish. Subsequently, survey including T1-DDS, Problem Areas In scale (PAID-20), fear hypoglycemia, social support, duration was answered by 2201 people T1D. Other person characteristics collected National Patient Register. HbA1c obtained Clinical Laboratory...