A5003505902- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Acute Ischemic Stroke Management
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Diabetes Treatment and Management
- Growth Hormone and Insulin-like Growth Factors
- Enterobacteriaceae and Cronobacter Research
- Intracranial Aneurysms: Treatment and Complications
- Hormonal and reproductive studies
- MicroRNA in disease regulation
- Pain Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Retinal Development and Disorders
- Metabolism, Diabetes, and Cancer
- Probiotics and Fermented Foods
- T-cell and B-cell Immunology
- Vascular Malformations Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Risk Factors
Liaoning Cancer Hospital & Institute
2021-2024
China Medical University
2021-2024
China National Petroleum Corporation (China)
2024
Jinzhou Medical University
2014-2023
Allen Institute
2023
Northwest A&F University
2019-2023
Capital Medical University
2016-2023
Huazhong Agricultural University
2020-2022
University of South Florida
2021-2022
Moscow Institute of Thermal Technology
2022
Large-scale genotyping plays an important role in genetic association studies. It has provided new opportunities for gene discovery, especially when combined with high-throughput sequencing technologies. Here, we report efficient solution large-scale genotyping. We call it specific-locus amplified fragment (SLAF-seq). SLAF-seq technology several distinguishing characteristics: i) deep to ensure accuracy; ii) reduced representation strategy reduce costs; iii) pre-designed scheme optimize...
Abstract Titanium dioxide nanoparticles (TiO 2 NPs) are widely used in toothpastes, sunscreens, and products for cosmetic purpose that the human use daily. Although neurotoxicity induced by TiO NPs has been demonstrated, very little is known about molecular mechanisms underlying brain cognition behavioral injury. In this study, mice were exposed to 2.5, 5, 10 mg/kg body weight (BW) nasal administration 90 consecutive days, respectively, their brains' injuries gene‐expressed profile...
Abstract HLA-E is a non-classical class I MHC protein involved in innate and adaptive immune recognition. While recent studies have shown can present diverse peptides to NK cells T cells, the repertoire recognized by CD94/NKG2x has remained poorly defined, with only limited number of peptide ligands identified. Here we screen yeast-displayed library context identify 500 high-confidence unique that bind both CD94/NKG2A or CD94/NKG2C. Utilizing sequences identified via yeast display...
Ultra-high temperature sterilized milk (UHT) is a popular dairy product known for its long shelf life and convenience. However, protein gel aging fat quality defects like creaming flavor deterioration may arise during storage. These problems are primarily caused by thermostable enzymes produced psychrotrophic bacteria. In this study, four representative bacteria strains which can produce were selected to contaminate UHT artificially. After 11, 13, 17 weeks of storage, the samples,...
The Himalayan marmot (Marmota himalayana) is a hibernating mammal that inhabits the high-elevation regions of mountains. Here we present draft genome marmot, with total assembly length 2.47 Gb. Phylogenetic analyses showed diverged from Mongolian approximately 1.98 million years ago. Transcriptional changes during hibernation included genes responsible for fatty acid metabolism in liver and involved complement coagulation cascades stem cell pluripotency pathways brain. Two selective sweep...
Pancreatic cancer is an aggressive and predicted to become the second leading cause of cancer-related deaths in China. To understand epidemic trend pancreatic formulate targeted preventive measures, it important analyze incidence mortality cancer.The data China were obtained from Global Burden Disease (GBD) data. We used joinpoint regression analysis calculate magnitude direction trends, age-period-cohort method effects chronological age, time period, birth cohort.The age-standardized rates...
Glioma is one of the most prevalent types malignancy in central nervous system worldwide, and prognosis patients with late stage glioma remains poor. Thus, development promising therapeutic strategies against essential. Long non‑coding RNAs (lncRNAs) are functional RNA molecules involved initiation progression tumors, including glioma. Investigation on regulatory roles lncRNAs may facilitate effective treatments. lncRNA NBAT1 associated growth metastasis cancer; however, its underlying...
Background and purpose Transvenous embolization (TVE) is widely utilized as an effective safe treatment option for cavernous sinus dural arteriovenous fistula (CS-dAVF); however, detecting the exact location of challenging. The present study identified angiographic features fistulous point evaluated match with microcatheter tip point. Materials methods An analysis cohort 45 consecutive patients CS-dAVF treated by TVE was analyzed retrospectively. were divided into two groups, 22 matches 23...
Glioma is a common type of tumor in human central nervous system, and it characterized with high mobility mortality. The prognosis patients advanced glioma remains poor. Thus, necessary to develop novel therapeutic approaches for the treatment this disease. Circular RNAs are group noncoding which have been detected eukaryotic cells. They tissue-specific more stable structure compared linear RNAs. Recently, studies revealed that certain circular involved biological processes such as gene...
We investigated the effects of long non-coding RNA (lncRNA) H19 on glioma cell proliferation, invasion, migration, and apoptosis underlying mechanisms.H19 expression in tissues, para-carcinoma lines was analyzed by Real-time polymerase chain reaction (RT-PCR). After transfecting U251 U87MG cells with siRNA-H19, proliferation detected counting kit-8 (CCK8) assay. Invasion migration were a transwell assay; cycle distribution measured flow cytometry analysis; Dvl2, GSK-3β, cyclin D1, β-catenin...
Abstract Cancer cell sensitivity or resistance is almost universally quantified through a direct surrogate measure of number. However, compound responses can occur many distinct phenotypic outcomes, including changes in growth, apoptosis, and non-apoptotic death. These outcomes have divergent effects on the tumor microenvironment, immune response, mechanisms. Here, we show that quantifying viability alone insufficient to distinguish between these responses. Using an alternative assay...
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Cerium is widely used in many aspects of modern society, including agriculture, industry and medicine. It has been demonstrated to enter the ecological environment, then transferred humans through food chains, causes toxic actions several organs brain animals. However, neurotoxic molecular mechanisms are not clearly understood. In this study, mice were exposed 0.5, 1, 2 mg/kg BW cerium chloride (CeCl3) for 90 consecutive days, their learning memory ability as well hippocampal gene expression...
Psychrotrophic and thermoduric bacteria are the main reasons for spoilage of dairy products. This study aims to address composition function psychrotrophic in eight groups raw milk samples obtained from Heilongjiang Province Inner Mongolia (China). Microbial enumeration showed an average total bacterial count 4.63 log c.f.u. ml −1 counts 4.82 . The mean mesophilic thermophilic were 3.68 1.81 , respectively. Isolated (26 genera 50 species) (20 32 high microbial diversity. Through metagenomic...
Glioma is a common type of malignancy in the central nervous system. The pathogenesis glioma complex and underlying mechanisms remain largely unknown. In our study, exosomes were exacted from patient samples, isolated confirmed by transmission electron microscope. expression circRNA_104948, miR-29b-3p DNMT3B determined using RT-qPCR. Proliferative activity cell was examined CCK-8 assay. Cell apoptotic rate evaluated flow cytometry. levels proliferation or apop-tosis markers western blotting....