A5102001245- Heavy Metal Exposure and Toxicity
- Nanoparticles: synthesis and applications
- Trace Elements in Health
- Cancer, Lipids, and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Advanced Nanomaterials in Catalysis
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- Air Quality and Health Impacts
- Cardiovascular and Diving-Related Complications
- Lung Cancer Treatments and Mutations
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- Alzheimer's disease research and treatments
- RNA modifications and cancer
- Anesthesia and Neurotoxicity Research
- Aluminum toxicity and tolerance in plants and animals
- Adsorption, diffusion, and thermodynamic properties of materials
- Silk-based biomaterials and applications
- Molecular Sensors and Ion Detection
Soochow University
2010-2024
Second Affiliated Hospital of Soochow University
2023-2024
Chongqing University
2022-2024
The Second Affiliated Hospital of Bengbu Medical College
2020-2023
Xiangya Hospital Central South University
2021-2023
Central South University
2021-2023
Shanxi University
2022
Ministry of Agriculture and Rural Affairs
2022
Institute of Food Science and Technology
2022
Chinese Academy of Agricultural Sciences
2022
Hepatocellular carcinoma (HCC) is a malignant tumor associated with high morbidity and mortality. Therefore, it of great importance to develop effective prognostic models guide clinical treatment in HCC. Protein lactylation found HCC tumors progression.The expression levels lactylation-related genes were identified from the TCGA database. A gene signature was constructed using LASSO regression. The value model assessed further validated ICGC cohort, patients split into two groups based on...
Abstract Titanium dioxide nanoparticles (TiO 2 NPs) are widely used in toothpastes, sunscreens, and products for cosmetic purpose that the human use daily. Although neurotoxicity induced by TiO NPs has been demonstrated, very little is known about molecular mechanisms underlying brain cognition behavioral injury. In this study, mice were exposed to 2.5, 5, 10 mg/kg body weight (BW) nasal administration 90 consecutive days, respectively, their brains' injuries gene‐expressed profile...
Ovarian cancer is the most lethal gynecological tumor, with a poor prognosis due to lack of early symptoms, resistance chemotherapy, and recurrence. Ferroptosis belongs regulated cell death family, characterized by iron-dependent processes. Here, comprehensive bioinformatics analysis was applied explore valuable prognostic model based on ferroptosis-related genes, which further validated in clinical OC samples.mRNA data normal ovarian tumor samples were obtained separately from GTEx TCGA...
Although liver toxicity induced by titanium dioxide nanoparticles (TiO2 NPs) has been demonstrated, very little is known about the molecular mechanisms of multiple genes working together underlying this type injury in mice. In study, we used whole-genome microarray analysis technique to determine gene expression profile livers mice exposed 10 mg/kg body weight TiO2 NPs for 90 days. The findings showed that long-term exposure resulted obvious accumulation and NP aggregation hepatocyte nuclei,...
Nanoparticulate titanium dioxide (nano-TiO2 ) is a widely used powerful nanoparticulate material with high stability, anticorrosion, and photocatalytic property. However, it possible that during nano-TiO2 exposure, there may be negative effects on cardiovascular system in intoxicated mice. The present study was therefore undertaken to determine -induced oxidative stress whether intoxication alters the antioxidant mouse heart exposed 2.5, 5, 10 mg/kg body weight for 90 consecutive days....
Despite the high morbidity and mortality, effective therapies for heart failure with preserved fraction (HFpEF) are limited as poor understand of its pathophysiological basis. This study was aimed to characterize cellular heterogeneity potential mechanisms HFpEF at single-cell resolution. An mouse model induced by a high-fat diet N-nitro-L-arginine methyl ester. Cells from hearts were subjected sequencing. The key protein expression measured Immunohistochemistry immunofluorescence staining....
Afatinib, a second-generation tyrosine kinase inhibitor (TKI), exerts its radiosensitive effects in nasopharyngeal carcinoma (NPC). However, the detailed mechanism of afatinib-mediated sensitivity to radiation is still obscure NPC.Quantitative phosphorylated proteomics and bioinformatics analysis were performed illustrate global phosphoprotein changes. The activity CD44-Stat3 axis Epithelial-Mesenchymal Transition (EMT)-linked markers evaluated by Western blotting. Wound healing transwell...
Although myocardial fibrosis is a common pathophysiological process associated with many heart diseases, the molecular mechanisms regulating development of have not been fully determined. Recently, single cell RNA sequencing (scRNA-seq) analysis has used to examine cellular fate and function during differentiation contributed elucidating various diseases. The main purpose this study was characterize cardiac fibroblasts (CFs) dynamic gene expression patterns in model pressure overload using...
Papillary thyroid carcinoma (PTC) is the most common pathological type of cancer. PTC patients with extrathyroidal extension (ETE) are associated poor prognoses. The preoperative accurate prediction ETE crucial for helping surgeon decide on surgical plan. This study aimed to establish a novel clinical-radiomics nomogram based B-mode ultrasound (BMUS) and contrast-enhanced (CEUS) in PTC. A total 216 between January 2018 June 2020 were collected divided into training set (n = 152) validation...
Abstract Abnormal lipid metabolism is an essential hallmark of glioblastoma. Hormone sensitive lipase (HSL), important rate-limiting enzyme contributed to lipolysis, which was involved in aberrant lipolysis glioblastoma, however, its definite roles and the relevant regulatory pathway have not been fully elucidated. Our investigations disclosed high expression HSL Knock-down restrained proliferation, migration, invasion glioblastoma cells while adding FAs could significantly rescue inhibitory...
Experimental studies have demonstrated that lanthanides could impair cognitive functions of children and animals, but very little is known about the hippocampal apoptosis its molecular mechanism. The study investigated signal pathway induced by intragastric administration CeCl(3) for 60 consecutive days. It showed cerium had been significantly accumulated in mouse hippocampus, caused impairment spatial recognition memory mice. effectively activated caspase-3 -9, inhibited Bcl-2, increased...
Numerous studies have demonstrated lanthanide (Ln) accumulation in the liver, and corresponding damage; however, very little work has been done to evaluate relationship between Ln‐induced liver injury its gene expression profile mice. In this study, gene‐expressed profiles male mice induced by oral administration of CeCl 3 (2 mg/kg) via gavage for 90 consecutive days were investigated. The results showed that cerium accumulation, inflammation, hepatocyte necrosis observed. exposure...
In the present study, expression of microRNA (miR)‑132 and mechanism by which it modifies angiogenesis in patients with ischemic cerebrovascular disease (ICD) was investigated. RNA isolation reverse transcription‑quantitative polymerase chain reaction were used to measure miR‑132 ICD. Inflammatory factors measured using ELISA kits western blotting B‑cell lymphoma‑2 (Bcl‑2)‑associated X/Bcl‑2 ratio (Bax/Bcl‑2 ratio), nuclear factor (NF)‑κB p65, matrix metalloproteinase‑9 (MMP‑9), vascular...
Cerium is widely used in many aspects of modern society, including agriculture, industry and medicine. It has been demonstrated to enter the ecological environment, then transferred humans through food chains, causes toxic actions several organs brain animals. However, neurotoxic molecular mechanisms are not clearly understood. In this study, mice were exposed 0.5, 1, 2 mg/kg BW cerium chloride (CeCl3) for 90 consecutive days, their learning memory ability as well hippocampal gene expression...