Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and its dismal prognosis indicates urgent need to elucidate potential oncogenic mechanisms. SIRT7 a classic NAD + -dependent deacetylase that stabilizes transformed state cancer cells. However, functional roles in PDAC are still unclear. Here, we found expression upregulated predicts poor PDAC. Then screened new interacting proteins by mass spectrometry results showed can interact with O-GlcNAc transferase...

Despite observations of decreased ANGPTL3 (angiopoietin-like protein 3) levels in tubular atrophy and renal interstitial fibrosis (RIF), its functional implications regulatory mechanisms RIF remain unclear. This investigation employed unilateral ureteral obstruction (UUO) mice as vivo model human proximal kidney tubuloepithelial HK-2 cells under TGF-β1 treatment vitro to explore RIF. The extent was evaluated using H & E staining Masson's trichrome staining. There a significant decrease an...

Fructose-1,6-bisphosphatase 1 (FBP1), a rate-limiting enzyme in gluconeogenesis, is important for cancer progression. The post-translational regulation of FBP1 hypoxic environments still unclear. Here, we report that down-regulated, and low expression level predicts poor prognosis pancreatic cancer. A environment makes more prone to degradation, this effect can be reversed by inhibiting global O-GlcNAcylation signalling. O-linked N-acetylglucosamine transferase (OGT) interacts with induces...

Over the past few years, Generative Adversarial Networks (GANs) have been receiving attention from image and time series domain. In this work, we propose a novel sequence based generative model to generate ECG samples for enhancing emotion state classification. Firstly, emotional related features are extracted represent in record. Secondly, random forest support vector machine trained classify arousal valence states. Then proposed is applied sample with corresponding label. Finally,...

The diagnosis algorithm of time-varying failures is considered for a class nonlinear systems that are affected by external disturbances. By combining the adaptive control theory and approach state observer, an anti-disturbance fault has been proposed. When disturbances internal exist simultaneously, designed able to give specific estimated values states failures, respectively, rather than just warning. asymptotical stability observer in guaranteed setting adjusting law failure vector. In...

In order to broaden the limited utilization range of wind power and improve charging discharging control performance storage battery in traditional small generation systems, a system based on vertical-axis off-grid induction generator is proposed this paper. The not only can run wide speed but also assist turbine realize self-starting at low speed. Combined with maximum point tracking method, slip frequency strategy employed regulate pulse width modulation (PWM) converter output when load...

The self-regulation of on-load tap changer (OLTC) transformation ratio is an important factor causing voltage instability. This paper introduces OLTC simulation models and their characteristics. Based on the sensitivity information, this deduces voltage-regulating effect in different load with usage analytic method. very complicated. For system operating conditions, types ratios, may be different. At last, summarizes current control strategies to prevent collapse.

Inflammation within areas of interstitial fibrosis and tubular atrophy (IF/TA) is associated with kidney allograft failure. The aim this study was to reveal new diagnostic markers IF/TA based on bioinformatics analysis. Raw data samples after transplantation control were extracted from the Gene Expression Omnibus (GEO) database (GSE76882 GSE120495 datasets), genes that differentially expressed between two groups (DEGs) screened. Set Enrichment Analysis (GSEA), ESTIMATE single sample GSEA...

This work report an industrial application of model predictive control (MPC) to a 600 MW coal fired electrical power plant. The coordinated system (CCS) is the most important part project. Dynamic models are obtained using multivariable closed-loop identification. In MPC control, plant nonlinearity caused by load changes treated simple LPV model. Initial tests show that technology can achieve much more stable operation plant, reduction consumption than 1%.

<title>Abstract</title> Fructose-1,6-bisphosphatase 1 (FBP1), a rate-limiting enzyme in gluconeogenesis, is important for cancer progression. The post-translational regulation of FBP1 hypoxic environments still unclear. Here, we report that down-regulated and low expression level predicts poor prognosis pancreatic cancer. Hypoxic environment makes more prone to degradation this effect can be reversed by inhibiting global O-GlcNAcylation signalling. O-linked N-acetylglucosamine transferase...

Motivation: Inflammatory myofibroblastic tumors (IMT) of the liver can mimic malignant tumors, yet, they lack definitive radiological characteristics. Goal(s): To identify gadoxetate acid-enhanced MRI (Gd-EOB-MRI) features distinguishing hepatic inflammatory tumor from colorectal metastasis (CLM). Approach: This retrospective study included 10 IMT (0.7-7.1 cm) and 28 CLM (0.4-5.4 patients who underwent Gd-EOB-MRI. Two reviewers assessed Results: Peripheral hypointense rim on T1WI, arterial...

Motivation: UTE MR has demonstrated its potential for evaluating pulmonary lesions, which could be employed assessing metastasis from hepatoblastoma. Goal(s): To investigate the diagnostic performance of detecting nodules and thus diagnosing in pediatric hepatoblastoma patients. Approach: Lung was assessed capability to detect metastasis. Results: a moderate sensitivity metastasis, while specificity is high. When it comes single nodules, detection rate with relatively high false positive...

Optical Phase Conductor is a new type of optical cable in power communication. Compared with OPGW and ADSS, OPPC has the advantages perfect integration transmission signal transmission, no additional load, good corrosion resistance, thermal stability long service life. This paper first analyzes characteristics OPPC, then elaborates its application smart grid. Combined line transformation, Shandong electric company State Grid studies key control engineering design construction.

This paper introduces the structure of aerodrome power supply equipment trouble- shooting system. It expatiates on software design MVC pattern in detail. And it realizes idea hign coheres and low coupling. also improve maintainability expansion.

Material experiment system of hydraulic servo is subject to load disturbance and a function standard mechanical parameters rock samples. Rock mass very discrete, anisotropy, composition not single inelastic [ . Traditional tester can't get the complete stress-strain curve material, in order solve shortage traditional system, this paper, fuzzy PID control successfully applied through experiments good effect.

In order to deal with diversity of massive data structures and the variety information formats, a novel mechanism is designed for unified management power grid planning data. By integrating many business systems including production system (PMS), geographic (GIS), energy (EMS), distribution network acquisition in supply company's adopting various technical means such as warehouse technology (e.g. ETL, Extract-Transform-Load) incremental capture, structure that supports whole process...

In order to adapt the digital transformation of State Grid company, it is important solve challenges in development company with advanced technique. Under this background, power dispatching automation (PDA) system's requirements artificial intelligence (AI) technology analyzed. Discussions about design principles, overall and specific details are made. Based on concept summarized, an application scheme AI system proposed so as provide theoretical reference for stability improvement new period.

Put the finite element analysis of line tower coupling modeling to collapse a 110 kV straight-line tower, study effect strong wind on transmission and wire. The results show that under action wind, material specification selected by part rods type is lower, cross section smaller, principal will be instable flexional compression, resulting in collapsed.

Arc suppression coil has been applied widely in power system.It focuses on the fault that arc often appears process, and divides to nature of faults. We also take corresponding treatment methods for different faults at same time. This article introduces failure processing detail, expounding respectively general methods, abnormal coil, action discontinued methods.

This paper analyzes the demagnetization performance of ferrite Permanent Magnets in dual rotor radial flux permanent magnet generator.Two different partial mechanisms DRRFPM generator are modeled and demonstrated.The 2D finite element analysis (FEA) is employed to accurately analyze distribution demagnetization.The FEA results for proposed verify validity model.The degradation induced by evaluated based on results.This research reveals most vulnerable region irreversible generator.