A5069442873- Neonatal and fetal brain pathology
- Hydrogen's biological and therapeutic effects
- Neuroscience of respiration and sleep
- Non-Invasive Vital Sign Monitoring
- Optical Imaging and Spectroscopy Techniques
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Biochemical effects in animals
- Neonatal Respiratory Health Research
- Child Nutrition and Feeding Issues
- Neurological Disease Mechanisms and Treatments
- Breastfeeding Practices and Influences
- Healthcare and Venom Research
- Infant Nutrition and Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Hemodynamic Monitoring and Therapy
Kagawa University
2018-2025
Acute kidney injury (AKI) has been reported to occur in 30–70% of asphyxiated neonates. Hydrogen (H2) gas became a major research focus neonatal medicine after the identification its robust antioxidative properties. However, ability H2 ameliorate AKI is unknown. We examined histopathological injuries piglet renal cortex on day 5 hypoxic-ischemic (HI) insult and if can alleviate injuries. Twenty piglets were divided into three groups: no (Control, n = 6), HI alone (HI, 8), with ventilation...
We previously reported the neuroprotective potential of combined hydrogen (H
Abstract Despite its poor outcomes, therapeutic hypothermia (TH) is the current standard treatment for neonatal hypoxic-ischaemic encephalopathy (HIE). In this study, due to antioxidant, anti-inflammatory, and antiapoptotic properties, effectiveness of molecular hydrogen (H 2 ) combined with TH was evaluated by means neurological histological assessments. Piglets were divided into three groups: insult normothermia (NT), (TH, 33.5 ± 0.5 °C), H ventilation (TH-H , 2.1–2.7%). administered 24 h....
The aim of this study was to use near-infrared time-resolved spectroscopy (TRS) determine the absolute values cerebral blood volume (CBV) and hemoglobin oxygen saturation (ScO2) during immediate transition period in term neonates changes optical properties such as differential pathlength factor (DPF) reduced scattering coefficient (μs’). CBV ScO2 were measured using TRS first 15 min after birth by vaginal delivery who did not need resuscitation. Within 2–3 birth, showed various increases or...
Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in newborns both high- low-income countries. The important determinants its pathophysiology are neural cells vascular components. In neonatal HIE, increased permeability due to damage the blood-brain barrier associated with seizures poor outcomes translational clinical studies. our previous studies, hydrogen gas (H2) improved neurological outcome HIE ameliorated cell death. this study, we used albumin...
Perinatal hypoxic-ischemic brain injury of neonates remains a significant problem worldwide. During the resuscitation period, changes in cerebral hemoglobin oxygen saturation (ScO2) have been identified by near-infrared spectroscopy (NIRS). However, asphyxiated neonates, relationship between these and is not known. Three-wavelength time-resolved spectroscopy, an advanced technology for NIRS, allows estimation ScO2 blood volume (CBV). Here, we studied CBV during period after insult...
Therapeutic hypothermia (TH) is a standard therapy for neonatal hypoxic-ischaemic encephalopathy. One potential additional the free radical scavenger edaravone (EV; 3-methyl-1-phenyl-2-pyrazolin-5-one).This study aimed to compare neuroprotective effects of plus therapeutic (TH + EV) with those TH alone after insult in newborn piglet. Anaesthetized piglets were subjected 40 min hypoxia (3-5% inspired oxygen), and cerebral ischaemia was assessed using blood volume. Body temperature maintained...
Abstract Neonatal hypoxic–ischemic encephalopathy is a notable cause of neonatal death and developmental disabilities. To achieve better outcomes, it important in treatment strategy selection to categorize the degree hypoxia ischemia evaluate dose response. In an asphyxia piglet model with histopathological brain injuries that we previously developed, animals survived 5 days after insult showed changes cerebral blood volume (CBV) reflected severity injuries. However, little known about...
Objective: Colostrum, the first form of human milk, is strongly encouraged for infants due to its benefits. During early postpartum (PP) period, secreted colostrum volume can be minimal, causing concerns among mothers about sufficient milk supply. Few studies have examined temporal changes in colostrum. This study aimed elucidate trajectory expressed 48 hours after delivery. Materials and Methods: was a cross-sectional observational performed at Kagawa National Children's Hospital. One...
Neural-activity-associated hemodynamic changes have been used to noninvasively measure brain function in the early developmental stages. However, temporal their hemodynamics are not always consistent with adults. Studies evaluated for a long period using same stimuli; therefore, this study examined normalized relative oxygenated hemoglobin (Δ[oxy-Hb]) full-term infants and compared them neonates up 10 months of age during administration tactile vibration stimuli limbs whole-head functional...
The effects of therapeutic hypothermia (TH) on renal function are not widely reported, especially in longer term animal models. hypothesis this study was that TH the kidneys hypoxic-ischemic newborn piglets would reduce pathological fibrosis.Twenty-five obtained within 24 h birth were classified into a control group (n = 5), an hypoxic insult with normothermia (HI-NT) 12), and (HI-TH) (33.5 °C ± 0.5 for h; n 8). Five days after insult, all sacrificed under deep anesthesia by isoflurane...
Abstract Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in newborns both high- low-income countries. The important determinants its pathophysiology are neural cells vascular components. In neonatal HIE, increased permeability due to damage the blood–brain barrier associated with seizures poor outcomes translational clinical studies. our previous studies, hydrogen gas (H2) improved neurological outcome HIE ameliorated cell death. this study, we used...
Abstract Therapeutic hypothermia is a standard therapy for neonatal hypoxic-ischaemic encephalopathy. One potential additional the free radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). To compare neuroprotective effects of plus therapeutic with those alone after insult in newborn piglet, anaesthetized piglets were subjected to 40 min hypoxia (3–5% inspired oxygen) and cerebral ischaemia was assessed by blood volume. Body temperature maintained at 38.5 °C normothermia group...
Abstract We previously reported the neuroprotective potential of combined hydrogen (H 2 ) gas ventilation therapy and therapeutic hypothermia (TH) by assessing short-term neurological outcomes histological findings 5-day neonatal hypoxic-ischemic (HI) encephalopathy piglets. However, effects H on cerebral circulation oxygen metabolism prognosis were unknown. Here, we used near-infrared time-resolved spectroscopy to compare between TH alone. Piglets divided into three groups: HI insult with...
Abstract To achieve better outcomes in hypoxic-ischemic encephalopathy, categorizing the degree of hypoxia-ischemia (HI) is important for selecting suitable candidates therapeutic hypothermia and any additional treatment strategies. We previously developed a novel model asphyxiated piglets with uniform histopathological brain injuries that survived 5 days after insult showed changes cerebral blood volume (CBV) reflected severity injuries. However, little known about relationship between CBV...