A5063027879- Neonatal and fetal brain pathology
- Lipoproteins and Cardiovascular Health
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Hydrogen's biological and therapeutic effects
- Neonatal Health and Biochemistry
- Infant Development and Preterm Care
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Thermal Regulation in Medicine
- Renal and Vascular Pathologies
- Non-Invasive Vital Sign Monitoring
- Hormonal Regulation and Hypertension
- Effects and risks of endocrine disrupting chemicals
- Optical Imaging and Spectroscopy Techniques
- Cancer, Lipids, and Metabolism
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Erythrocyte Function and Pathophysiology
- Biochemical effects in animals
- Lipid metabolism and disorders
- Anesthesia and Neurotoxicity Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiac Arrest and Resuscitation
- Dye analysis and toxicity
- Blood Pressure and Hypertension Studies
- Hedgehog Signaling Pathway Studies
Kagawa University
2007-2025
Kindai University
2024
Sakai Municipal Hospital
2024
Japan Pediatric Society
2023
Takamatsu University
2023
Kagawa University Hospital
2016
Nihon University
1998-1999
Akita Red Cross Hospital
1992
Kawasaki Medical School
1984-1989
Tohoku University
1975-1978
In Japan, the mortality rate of extremely low birth weight (ELBW) infants is notably in comparison with other developed countries, but prevalence chronic lung disease (CLD) and retinopathy prematurity (ROP) relatively high. This study aimed to estimate morbidity ELBW born 2015 who were admitted neonatal intensive care units (NICUs) Japan examine factors that affected short-term outcomes these infants. We also compared 2005, 2010, 2015.We analyzed mortality, morbidity, related infants, using...
Familial hypercholesterolemia (FH) is an underdiagnosed autosomal dominant genetic disorder characterized by high levels of plasma low-density lipoprotein cholesterol (LDL-C) from birth. This study aimed to assess the identification FH in children with LDL-C who are identified a universal pediatric screening Kagawa, Japan.In 2018 and 2019, 15,665 aged 9 or 10 years underwent lipid as part annual health checkups for prevention lifestyle-related diseases Kagawa prefecture. After excluding...
Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels, which increases the risk of premature coronary artery disease. Early detection and treatment are vital, especially in children. To improve FH diagnosis children, Japan Atherosclerosis Society (JAS) released new guidelines July 2022. This study assessed compared sensitivity specificity clinical diagnostic criteria from JAS pediatric 2017
Acute kidney injury (AKI) has been reported to occur in 30–70% of asphyxiated neonates. Hydrogen (H2) gas became a major research focus neonatal medicine after the identification its robust antioxidative properties. However, ability H2 ameliorate AKI is unknown. We examined histopathological injuries piglet renal cortex on day 5 hypoxic-ischemic (HI) insult and if can alleviate injuries. Twenty piglets were divided into three groups: no (Control, n = 6), HI alone (HI, 8), with ventilation...
Aim: Familial hypercholesterolaemia (FH), an autosomal-dominant disorder, requires early diagnosis to prevent atherosclerosis in children and coronary artery disease (CAD) their parents. This study aimed evaluate the effectiveness barriers of reverse cascade screening (RCS) combined with universal cholesterol (UCS) for paediatric FH. Methods: We performed RCS UCS FH between January 2018 July 2023. Family pedigree was evaluated second-degree relatives, using a child genetic as proband. Based...
The Friedewald equation, commonly used to calculate low-density lipoprotein cholesterol (LDL-C), occasionally yields inaccurate estimations for very-low-density cholesterol, suggesting the need an alternative method such as Martin equation. In this study, we aimed evaluate discrepancies between and equations, particularly in context of pathogenic variants associated with familial hypercholesterolemia (FH). We evaluated LDL-C levels calculated using presence FH 53 children detected through...
We previously reported the neuroprotective potential of combined hydrogen (H
Abstract Therapeutic drug monitoring is generally unnecessary in caffeine treatment for apnea of prematurity, as serum concentrations preterm infants are normally markedly lower than those at which intoxication occurs. However, several studies have reported having developed toxicity. This retrospective observational study, conducted a tertiary center Kagawa, Japan, aimed to evaluate the correlation between maintenance dose and determine leading suggested toxic levels. We included 24...
Problematic Internet use (PIU) remains a significant social concern in Japan and across the globe. Numerous studies have been conducted to examine prevalence of PIU, its association with lifestyle habits mental health status. To best our knowledge, few examined between parental attachment PIU Japan. Furthermore, preventive measures primarily targeted adolescents via education. Therefore, this study we explored styles among seek new approach for development appropriate, effective measures.A...
Plasma renin activity (PRA) was measured in 38 cases of aortitis syndrome. The values resting peripheral vein blood PRA were 32.2±4.2 (SE) mμg/ml. These 3 times higher than those normal subjects. Hypertension due to renal arterial stenosis observed 18 cases. Their 41.2±6.0mμg/ml, while the remaining 20 patients without renovascular hypertension 24.2±5.4mμg/ml. belonging aortic arch type or extensive had 2 abdominal type. with obstruction common carotid arteries significantly these lesions....
The antiviral and antibacterial properties of ozone gas have been utilised for air on-site disinfection. However, excess exposure is toxic to humans, necessitating the monitoring levels. While this has achieved using indicators, determining levels at intermediate time points during remains challenging owing current ones being capable measuring only endpoints. Shifts in endpoint are also difficult as coverage ranges indicators dependent on a single colour dye. indicator that covers wide range...
Abstract Background Familial Hypercholesterolaemia (FH) is an autosomal dominant genetic disorder that prevalent in one out of every 300 individuals the general population. Recognized as actionable condition, early diagnosis FH children crucial to prevent onset atherosclerosis, and equally important identification parents before development coronary artery disease events. Therefore, significance universal screening during childhood combined with reverse cascade has been increasingly...
The effect of furosemide on urinary kallikrein excretion was studied in 10 patients with essential hypertension and 9 normal volunteer subjects. After intravenous administration 2 hours upright posture, urine volume (UV), sodium (UNaV) potassium (UKV) excretion, plasma renin activity (PRA), aldosterone concentration (PAC) markedly increased. However, the augmentation (1.50±0.19 EU/2hr) less remarkable than that subjects (2.33±0.24EU/2hr), although same degrees response were observed PRA PAC....
Perinatal hypoxic-ischemic brain injury of neonates remains a significant problem worldwide. During the resuscitation period, changes in cerebral hemoglobin oxygen saturation (ScO2) have been identified by near-infrared spectroscopy (NIRS). However, asphyxiated neonates, relationship between these and is not known. Three-wavelength time-resolved spectroscopy, an advanced technology for NIRS, allows estimation ScO2 blood volume (CBV). Here, we studied CBV during period after insult...
It is important to identify the pathological characteristics of cerebral circulation and oxygen metabolism at bedside in children with congenital heart disease (CHD) prevent neurodevelopmental impairments. The brain regional saturation index (rSO2 ) can be easily obtained near-infrared spectroscopy has been widely used management CHD recent years.To determine if rSO2 before or after surgery a good predictor metabolism, we investigated impact different clinical variables on correlation...
HPLC analysis revealed that five subsidiary colors were present in a commercial Food Blue No. 1 (Brilliant FCF) product. Among them, major C, D, and E isolated. On the bases of spectroscopic analyses, their structures identified as disodium salt 2-[[4-[N-ethyl-N-(3-sulfophenylmethyl)amino]phenyl][4-[N-ethyl-N-(4-sulfophenylmethyl)amino]phenyl]methylio]benzenesulfonic acid,...
A magenta subsidiary colour was isolated from commercial Food Blue No. 1 (B-1; Brilliant FCF). The absorption maximum for this at 580 nm is outside of the range 614-628 found other colours and m,m-B-1. On basis MS NMR analyses, structure elucidated as disodium salt 2-[[4-[N-ethyl-N-(3-sulphophenylmethyl)amino]phenyl][4-oxo- 2,5-cyclohexadienylidene]methyl]benzenesulphonic acid. HPLC analyses revealed that 24 batches (three manufacturers) contain 0.1-0.8% (average: 0.5%) colour.
Abstract Two neoplastic human cell lines, WI‐38 CT‐1 and SUSM‐1, which were transformed in vitro with gamma rays 4‐nitroquinoline 1‐oxide, respectively, grew continuously a serum‐free defined medium. The medium used was 1:1 mixture by volume of Dulbecco's modified Eagle's Ham's F12 (DF) supplemented 0.1% bovine serum albumin fraction V, 10 μg/ml transferrin, 1 insulin, 5 oleic acid. In the case 100 fetuin added to cultures when cells subcultured. Under these conditions growth rates two lines...
Resting plasma renin activity (PRA) and PRA after the load of furosemide i. v. two-hour's upright posture were studied on 139 healthy normotensive subjects 200 patients with essential hypertension. Regarding age factor, estimated values in control very low advanced ages over 60 years, while no significant differences found aged from 20 to 59 years. In hypertension, a similar relationship between aging was observed. The hypertension classified into 3 groups according resting values; low,...
There are currently no definitive guidelines regarding newborns born to mothers with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed investigate the medical care and management that provided or would provide for such newborns.A web survey was conducted between September October 2020. A total of 624 hospitals, which generally accept pregnant women delivery, were involved in this study. The included number SARS-CoV-2 infection evaluated...
Background: Human milk banks have been established to provide human preterm infants who are unable obtain from their mothers. Donor screening methods vary, and prospective donors commonly screened for drug recreational substance use through behavioral screening. Although the risk of illegal consumption in Japan is extremely low, caffeine may be consumed unknowingly can found milk. To date, only a few reports conducted on concentration donor Research Aim: This study aimed examine...
It is important that blood glucose concentrations be accurately and conveniently measured in infants. However, especially the early neonatal period, point-of-care testing devices used for adults may not measure neonates.