A5102856761- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Neonatal Respiratory Health Research
- Heart Rate Variability and Autonomic Control
- Lipoproteins and Cardiovascular Health
- Fetal and Pediatric Neurological Disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- Gastrointestinal Tumor Research and Treatment
- Cardiac Structural Anomalies and Repair
- Organ Donation and Transplantation
- Genetic and Kidney Cyst Diseases
- Tumors and Oncological Cases
- Potassium and Related Disorders
- Pregnancy-related medical research
- Neurological and metabolic disorders
- Cardiac Fibrosis and Remodeling
- Anesthesia and Neurotoxicity Research
- Medicinal plant effects and applications
- Cancer Treatment and Pharmacology
- Coronary Interventions and Diagnostics
- Signaling Pathways in Disease
- Congenital Heart Disease Studies
Kagawa University Hospital
2024
Kagawa University
2012-2024
Hyogo Medical University
2021
Shinshu University
2014
Industrial Research Institute of Ishikawa
2012
Boston Children's Hospital
2012
Nagano Children's Hospital
2011
Background Cardiac rupture is an important cause of death in the acute phase after myocardial infarction (MI). Macrophages play a pivotal role cardiac remodeling MI. Apoptosis inhibitor macrophage (AIM) secreted specifically by macrophages and contributes to accumulation inflamed tissue maintaining survival recruiting macrophages. In this study, we evaluated AIM infarcted myocardium Methods results Wild-type (WT) AIM‒/‒ mice underwent permanent left coronary artery ligation were followed-up...
Background:Atrial fibrillation (AF), which contributes to an increased risk of stroke, frequently remains undetected, suggesting unmet need for easier and more reliable AF screening. The reports on screening using Omron blood pressure (BP) monitor with irregular heartbeat (IHB) detector show inconsistent results, so the aim this study was develop a novel algorithm accurately diagnose 3 BP measurements automated IHB detector.
To evaluate the efficacy and safety of a grasping-type knife, called Clutch Cutter (CC), for colorectal endoscopic submucosal dissection (C-ESD). This was randomized prospective study. Patients who underwent C-ESD neoplasms >20 mm <50 in size were enrolled, dividing into two groups: ESD using needle type dual knife alone (D-group) circumferential incision followed by CC (CC-group). The primary outcome self-completion rate. secondary outcomes intraoperative complication rate, procedure time,...
Background:The lipid component of coronary plaques is associated with their vulnerability. The aim this study was to investigate which risk factors were relevant in predicting serial changes the as evaluated by integrated backscatter intravascular ultrasound (IB-IVUS).
Pulmonary arterial hypertension (PAH) is a multifactorial disease characterized by pulmonary vasoconstriction and remodeling. Src family tyrosine kinases, including Fyn, play critical roles in vascular remodeling via the inhibition of STAT3 signaling. EPA known to inhibit Fyn kinase activity. This study investigated therapeutic potential underlying mechanisms its metabolite, resolvin E1 (RvE1), treat PAH using monocrotaline-induced model rats (MCT-PAH), human artery endothelial cells...
Abstract Congenital chloride diarrhea (CLD) is a rare hereditary disease. The basic defect of CLD massive loss Cl − and fluid into the ileum colon. Prenatal diagnosis this disease quite important because infant requires electrolyte supplementation from early postnatal period. Two cases in which prenatal diagnoses were made siblings are reported. Extreme imbalance may cause fetal cardiac dysfunction or poor general condition leading to non‐reassuring status with CLD. Therefore, frequent...
Heart failure has been divided into heart with preserved left ventricular (LV) ejection fraction (EF) and reduced EF, because the pathophysiologies of two conditions are different. Cardio-ankle vascular index (CAVI) is a new indicator arterial stiffness, most conspicuous feature CAVI its independence blood pressure at time measurement. Arterial stiffness considered to increase LV afterload, which requires special care avoid onset failure. We compared correlation as assessed by function in 44...
Abstract Background Familial Hypercholesterolaemia (FH) is an autosomal dominant genetic disorder that prevalent in one out of every 300 individuals the general population. Recognized as actionable condition, early diagnosis FH children crucial to prevent onset atherosclerosis, and equally important identification parents before development coronary artery disease events. Therefore, significance universal screening during childhood combined with reverse cascade has been increasingly...
Ophiocordyceps sinensis (OCS), an entomopathogenic fungus, is known to exert antiproliferative and antitissue remodeling effects. Vascular vasoconstriction play critical roles in the development of pulmonary hypertension (PH). The therapeutic potential OCS for PH was investigated using rodent models, cultured artery endothelial smooth muscle cells (PAECs PASMCs), with a focus on involvement TRPM7. ameliorated PH, right ventricular hypertrophy dysfunction monocrotaline-induced rats. genetic...
The latest guideline from the European Society of Cardiology and Respiratory recommends initial combination therapy with oral pulmonary arterial hypertension (PAH)-specific drugs in PAH patients World Health Organization functional class (WHO-FC) II or III. However, whether this improves hemodynamics clinical failure events regardless PAH-specific remains unknown. This study was designed to evaluate macitentan plus riociguat selexipag showed equal efficacy reducing vascular resistance (PVR)...
The impact of nicorandil as adjunctive therapy for percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI) is controversial. We performed 15O-labeled water positron emission tomography (PET) to quantify regional perfusion STEMI who received or no during PCI. PCI was within 8 h after onset 33 patients. 14 intracoronary 2 mg immediately recanalization the culprit lesion (Nico group). After 3–4 weeks, PET which blood flow (MBF) measured at baseline...
Abstract Antimicrobial-product package inserts and insufficient staffing impede routine carbapenem monitoring in the inpatient setting Japan. The collaboration between antimicrobial stewardship teams clinical pharmacists was associated with a sustained improvement dosing optimization. Our findings could be of use to countries inadequate use.
常染色体優性多発性嚢胞腎（ADPKD）は，PKD遺伝子変異により両側腎臓に多数の嚢胞が進行性に発生・増大し，腎臓以外の種々の臓器障害も生ずる遺伝性疾患である．我々は多彩な血管合併症を有するADPKDによる末期腎不全に対し，脳動脈瘤コイル塞栓術，大動脈弁置換+上行大動脈瘤置換術を腎移植手術前に施行し，適切な血液浄化療法による体液管理を行った後，安全に生体腎移植を遂行できた症例を経験したので報告する．
Automatic pacing threshold adjustment algorithms and remote monitoring are widely used to improve the utility of pacemakers ensure patient safety. However, healthcare providers involved in management permanent should know potential pitfalls these functions. In this report, we present a case atrial failure induced by automatic algorithm that went unnoticed even under monitoring.
Introduction: Trastuzumab is known to reduce the mortality rate, recurrence and metastasis rate in Human epidermal growth factor receptor type 2 (HER2)-positive breast cancer patients, it recommended administer for 12 months all early-stage HER2-positive patients. However, trastuzumab administration can lead Cancer Therapeutics-Related Cardiac Dysfunction (CTRCD). The guidelines suggest that regular echocardiography every 3 useful early detection of CTRCD, but there are no tests available...
Purpose: Controversies exist regarding the impact of nicorandil as adjunctive therapy for direct coronary stenting in patients with ST elevation myocardial infarction (STEMI).Therefore, we performed O-15 water positron emission tomography (water PET) to quantify regional perfusion STEMI who received or no during successful stenting. Methods: In 28 (65+/-13 yrs: 22 males), was within 8 hrs after onset. Five underwent intracoronary administration (i.c.) 4 mg immediately first recanalization...
without any antiarrhythmic agents for at least one year.Baseline characteristics including echo-cardiographic parameters and fibrillation cycle length (FCL) calculated from Fast Fourier Transformation analysis of the waves in surface ECG were evaluated.Results: Over an average follow-up period 512 days, 16 patients exhibited recurrence AF (28%).On multivariate analysis, FCL E/e' echocardiographic parameter independent predictors AF.In a Cox proportional-hazards, with >160ms (cut-off value...