A5000316211- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Gastrointestinal Bleeding Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Gastroesophageal reflux and treatments
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- Diverticular Disease and Complications
- Helicobacter pylori-related gastroenterology studies
- COVID-19 and healthcare impacts
- Porphyrin Metabolism and Disorders
- Dysphagia Assessment and Management
- Infection Control and Ventilation
- Colorectal Cancer Treatments and Studies
- Biliary and Gastrointestinal Fistulas
- Colorectal Cancer Surgical Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
- Minimally Invasive Surgical Techniques
- Vascular Anomalies and Treatments
Kagawa University
2015-2024
The Japanese Society of Gastroenterological Surgery
2024
Iwate Medical University
2024
Onomichi General Hospital
2024
Hiroshima University
2024
Kagawa University Hospital
2022
National Cancer Center Hospital East
2012-2022
Creative Research Enterprises (United States)
2016
American Society for Gastrointestinal Endoscopy
2016
National Cancer Center
2013
Endoscopic closure of post-endoscopic submucosal dissection (ESD) defects can reduce postoperative adverse events [1]. Innovative techniques such as use an endoloop [2], endoscopic ligation with O-ring [3], and reopenable clip over the line method [4] have recently been developed; however, complexity time-consuming nature procedures remain problematic. We introduce a strategy using new endoclip mantis-like claw (MANTIS Clip; Boston Scientific, Marlborough, Massachusetts, USA) ([Fig. 1]) that...
Highlights•Lynch Syndrome (LS) subjects gut microbiota has lower diversity compared to non-LS•Distinct enrichment of F. nucleatum and fap2 in LS CRC subjects•LS exhibits increased lysine arginine metabolism•Distinct fecal metabolites with minimal dysbiosis no adenomaSummaryAccumulating evidence demonstrates clear correlation between the sporadic colorectal cancer (CRC). Despite this, there is limited understanding association Lynch (LS), a hereditary type CRC. Here, we analyzed shotgun...
Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB) and a widely used antihypertensive, has been shown to inhibit proliferation of various cancer types. This study evaluated effects telmisartan on human ESCC in vitro vivo sought identify microRNAs (miRNAs) involved these antitumor effects. We examined three lines (KYSE150, KYSE180, KYSE850). Telmisartan inhibited by inducing S-phase...
Abstract Background We examined the efficacy of a novel endoscopic ligation technique with O-ring closure (E-LOC) to prevent bleeding after gastric submucosal dissection (ESD) under antithrombotic therapy. Methods This single-center prospective study involved consecutive patients who were taking agents and underwent ESD. E-LOC was performed by anchoring nylon loop hemoclips on both defect edges and/or exposed muscle layer, using band around these deployed clips. The primary outcome post-ESD...
Galectin-9 (Gal-9) enhances tumor immunity mediated by T cells, macrophages, and dendritic cells. Its expression level in various cancers correlates with prognosis. Furthermore, Gal-9 directly induces apoptosis cancers; however, its mechanism of action bioactivity has not been clarified. We evaluated antitumor effect against esophageal squamous cell carcinoma (ESCC) to analyze the dynamics apoptosis-related molecules, elucidate action, identify relevant changes miRNA expressions. KYSE-150...
The recently developed endoscopic full-thickness resection technique requires reliable closure. main closure methods are the purse-string suture (PSS) and over-the-scope clip (OTSC) technique; however, basic data on strength of each lacking. This study was performed to compare strengths these two in an ex vivo porcine model.
Background and study aims Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome caused by a germline mutation in the coli (APC) gene, characterized presence of more than 100 polyps colorectum. The upper gastrointestinal tract extracolonic site for malignancy patients with FAP. frequency death Japanese FAP because gastric cancer 2.8 % that colon 60.6 %. Few studies have reported diseases In present study, we investigated clinical outcomes diagnosed neoplasms. Patients methods...
Abstract Background and study aims Endoscopic ultrasound-guided fine needle aspiration (FNA) for gastrointestinal subepithelial lesions (SELs) has limited diagnostic accuracy due to technical problems small lesion size. We previously reported a novel submucosal tunneling biopsy (STB) technique sampling SELs. This aimed evaluate the ability safety of STB compared that FNA Patients methods The was non-randomized, prospective comparative with crossover design in patients endoluminal gastric...
Background: After colorectal cancer and desmoid tumors, duodenal adenocarcinoma is the next leading cause of death in familial adenomatous polyposis (FAP) patients, but it has not been thoroughly investigated. Patients Methods: To investigate clinical course neoplasia, including adenoma cancer, we investigated 77 Japanese FAP patients treated at National Cancer Center Hospital, Tokyo, Japan. We evaluated clinicopathologic features, Spigelman severity score, management neoplasms. Data were...
This study aimed to investigate the relationship between histological type of colorectal lymphoma and its endoscopic features.We retrospectively analyzed patients with primary who were diagnosed using colonoscopy biopsy specimens at National Cancer Center Hospital, Tokyo, Japan. The lesions macroscopically classified into following types via colonoscopy: polypoid, ulcerative, multiple lymphomatous polyposis, diffuse, mixed.A total 117 identified in 90 enrolled this study. Of these, 59 (50%)...
A prospective observational study was conducted to establish the procedure of hybrid endoscopic full-thickness resection (EFTR) using an existing flexible endoscope. The present included 16 patients who underwent EFTR between September 2009 and February 2013 for gastric gastrointestinal stromal tumor (GIST). were selected following inclusion criteria histological findings: Mitotic counts <5/high-power field immunohistochemical stains positive KIT or cluster differentiation 34 (CD34). mean...
Endoscopic closure of a gastrointestinal artificial defect effectively reduces the incidence postoperative adverse events [1], especially delayed bleeding due to antithrombotic drugs. However, although several techniques have been developed, including endoloop [2], multiple clip-and-line [3], and hand suturing [4], there is still no convenient reliable technique for stomach because thick gastric wall. One important issue that limited mucosal results in formation bridge cavity, leading...
Narrow band imaging with magnifying endoscopy (NBI-ME), which is useful for the assessment of micro-vessels, has excellent diagnostic potential early gastrointestinal epithelial neoplasia. Conventional tools uterine cervical tumors are still unsatisfactory. An accurate tool required to preserve reproductive ability young women tumors. Flexible NBI-ME was performed in patients squamous cell lesions that further examinations based on their Pap smear results (cytology ≥ low-grade...
Abstract Background and study aims Exposed endoscopic full-thickness resection (EFTR) enables the operator to obtain a sufficient surgical margin. However, insufflation leakage secure closure (EFTC) remain problematic. This aimed evaluate safety feasibility of new exposed EFTR. Patients methods EFTR was performed for 2-cm virtual lesions in different locations upper stomach four dogs. mainly involved half-circumferential endpoint clip-line traction. Pulley traction applied with forward...
To evaluate the efficacy and safety of a grasping-type knife, called Clutch Cutter (CC), for colorectal endoscopic submucosal dissection (C-ESD). This was randomized prospective study. Patients who underwent C-ESD neoplasms >20 mm <50 in size were enrolled, dividing into two groups: ESD using needle type dual knife alone (D-group) circumferential incision followed by CC (CC-group). The primary outcome self-completion rate. secondary outcomes intraoperative complication rate, procedure time,...
Endoscopic submucosal dissection (ESD) for upper gastrointestinal (GI) subepithelial tumors (SETs) originating in the muscularis propria (MP) layer is associated with numerous issues regarding secure closure and measures against accidental perforation. However, symptomatic benign GI SETs or carcinoid submucosa (SM) may be safely resected en-bloc using ESD. In this study, feasibility safety of ESD as a novel method endoscopic resection such revealed on ultrasonography (EUS) was investigated....
The aim of the present report was to investigate efficacy local steroid injection and oral administration contralateral a severe contracted scar large endoscopic submucosal dissection ( ESD ) for gastric cancer. Among 254 cases that underwent , seven patients resection more than three‐quarters circumference stomach. Two were excluded because they did not meet curative criteria J apan G astroenterological E ndoscopy S ociety. Therefore, in five patients, circumferentiality, symptom appearance...
Although the macroscopic characteristics of submucosal tumors (SMTs), such as gastrointestinal stromal (GISTs), have been characterized, assessment SMTs by their endoscopically visualized features (EVF; which are observed endoscopic imaging under direct view) remains unevaluated. The aim present study was to investigate potential diagnostics for using EVF. EVF 26 gastric SMT cases, in final pathological diagnosis obtained core biopsy endoscopy with mucosal flap method, were retrospectively...
Background: Little is known about the clinicopathological characteristics of superficial spreading-type esophageal carcinoma extending ≥5 cm along long axis esophagus. This study was aimed at investigating frequency lymph node metastasis (LNM) in patients with carcinoma. Methods: We reviewed data 320 squamous cell who had undergone esophagectomy dissection our hospital between 1986 and 2010. The incidence LNM compared spreading (≥5 cm) nonspreading (< 5 types. Results: multivariate...
Background and Aims: Endoscopic submucosal dissection (ESD) seems to be a reasonable option for gastrointestinal subepithelial lesions (SELs) localized within the submucosa. Indications ESD include small neuroendocrine tumors (NETs) indeterminate SELs. However, prospective data regarding surveillance remain unclear. This study was performed prospectively investigate outcomes of ESD, including organ-specific mid-term prognosis.
 Methods: multicenter included 57 patients who underwent...