A5028952356- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- Hepatitis B Virus Studies
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Bioinformatics and Genomic Networks
- Evolution and Genetic Dynamics
- Genomics and Chromatin Dynamics
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Cancer-related gene regulation
- Nutrition, Genetics, and Disease
- Heat shock proteins research
- Genomics and Rare Diseases
- Gastrointestinal Tumor Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- Neuroblastoma Research and Treatments
Tokyo Metropolitan Institute of Gerontology
2024-2025
The University of Tokyo
2014-2024
Weatherford College
2024
National Cancer Research Institute
2024
Osaka University
2024
Tokyo Institute of Technology
2024
National Cancer Centre Japan
2016-2023
Tokyo Metropolitan Komagome Hospital
2013
Charité - Universitätsmedizin Berlin
2009-2011
Abstract The neuroendocrine carcinoma of the gastrointestinal system (GIS-NEC) is a rare but highly malignant neoplasm. We analyzed 115 cases using whole-genome/exome sequencing, transcriptome DNA methylation assays, and/or ATAC-seq and found GIS-NECs to be genetically distinct from tumors (GIS-NET) in same location. Clear genomic differences were also evident between pancreatic NECs (Panc-NEC) nonpancreatic (Nonpanc-NEC). Panc-NECs could classified into two subgroups (i.e., “ductal-type”...
Abstract Nrf2 activation promotes resistance to chemical carcinogenesis in animal models, but activating mutations also confer malignant characters human cells by antioxidative/detoxifying enzymes and metabolic reprogramming. In this study, we examined how these contradictory activities of Nrf2, cancer chemoprevention cell growth enhancement, can be reconciled an established mouse model urethane-induced lung carcinogenesis. Using Keap1-knockdown (kd) mice, which express high levels found...
Abstract Tumor-associated macrophages affect tumor progression and resistance to immune checkpoint therapy. Here, we identify the chemokine signal regulator FROUNT as a target control tumor-associated macrophages. The low level expression in patients with cancer correlates better clinical outcomes. Frount -deficiency markedly reduces decreases macrophage tumor-promoting activity. is highly expressed macrophages, its myeloid-specific deletion impairs growth. Further, anti-alcoholism drug...
Myxofibrosarcoma (MFS) is a common adult soft tissue sarcoma characterized by an infiltrative growth pattern and high local recurrence rate. Here we report the genetic epigenetic landscape of MFS based on results whole-exome sequencing (N = 41), RNA 29), methylation analysis using 41 MFSs as discovery set, subsequent targeted 140 genes in entire cohort 99 17 MFSs' data from TCGA. Fourteen driver are identified, including potentially actionable therapeutic targets seen 37% cases. There...
Mucinous gastric carcinoma (MGC) is a unique subtype of cancer with poor survival outcome. Comprehensive molecular profiles and putative therapeutic targets MGC remain undetermined. We subjected 16 tumour-normal tissue pairs to whole-exome sequencing (WES) an expanded set 52 subsequent targeted sequencing. The latter focused on 114 genes identified by WES. Twenty-two histologically differentiated MGCs (D-MGCs) 46 undifferentiated (U-MGCs) were analysed. Chromatin modifier genes, including...
Abstract Gastric cancer (GC) is one of the most common and life‐threatening malignancies. The course disease tumor aggressiveness vary among GCs, although how early fate determined by what factors remains elusive. To solve this question, we collected 43 gastric intramucosal neoplasias (GINs), comprising dysplasia/intraepithelial neoplasia (D/IEN; a premalignant lesion) minute GC (miGC; ≤10 mm) intestinal histotype performed targeted deep DNA sequencing 67 GC‐related genes derived from...
The transcription factor E74-like 3 (ELF3) is inactivated in a range of cancers, including biliary tract cancer (BTC). Here, we investigated the tumor-suppressive role ELF3 bile duct cells by identifying several previously unknown direct target genes that appear to be implicated carcinogenesis. directly repressed ZEB2, key regulator epithelial-mesenchymal transition, and upregulated expression CGN, an integral element lumen formation. Loss led decreased cell-cell junctions enhanced cell...
Cancer prognosis markers are useful for treatment decisions; however, the omics-level landscape is not well understood across multiple cancer types. Pan-Cancer Analysis of Whole Genomes (PCAWG) provides unprecedented access to various types molecular data, ranging from typical DNA mutations and RNA expressions more deeply analyzed or whole-genomic features, such as HLA haplotypes structural variations. We PCAWG data 13 1,514 patients identify belonging 17 features in survival analysis based...
Abstract Cholangiocarcinoma is an aggressive malignancy with a poor prognosis, no effective therapy other than surgical resection. Heat shock protein 90 (HSP90) key component of multichaperone complex involved in the posttranslational folding number client proteins, many which play essential roles tumorigenesis. Here, we attempted to clarify its prognostic significance and potential utility as therapeutic target cholangiocarcinoma. Immunohistochemical expression HSP90 was assessed...
Abstract Recurrent H3F3A and IDH2 mutations have been reported in giant cell tumor of bone (GCTB). However, the incidences varied, other molecular genetic alterations not identified due to small number cases analyzed with comprehensive methods. Moreover, relative sensitivities Sanger sequencing next‐generation (NGS) for detection DNA extracted from archival formalin‐fixed paraffin‐embedded (FFPE) samples clinical diagnosis assessed. To address these issues, we conducted whole‐exome 7 GCTBs...
Abstract Epstein‐Barr virus (EBV) is one of the major drivers gastric carcinogenesis. EBV infection established before tumour initiation and generally maintained throughout development; however, significance in maintenance progression remains to be elucidated. Here, we report eight cases EBV‐associated carcinoma (EBVaGC) with intratumoural heterogenous expression EBV‐encoded small RNA ( EBER ), a highly expressed latent gene EBV, demonstrate clinicopathological characteristics these rare...
Abstract Structural variants (SVs) are responsible for driver events in gastric cancer (GC); however, their patterns and processes remain poorly understood. Here, we examine 170 GC whole genomes to unravel the oncogenic structural aberration landscape identify six rearrangement signatures (RSs). Non-random combinations of RSs elucidate distinctive subtypes comprising one or a few dominant RS that associated with specific ( BRCA1/2 defects, mismatch repair deficiency, TP53 mutation)...
The prolonged presence of infectious SARS-CoV-2 in deceased patients with COVID-19 has been reported. However, virus titers have not determined. Such information is important for public health, death investigation, and handling corpses. aim this study was to assess the level infectivity corpses COVID-19.We collected 11 nasopharyngeal swabs 19 lung tissue specimens from autopsy cases 2021. We then investigated viral genomic copy number by real-time reverse transcription-polymerase chain...
The prognosis of gastric cancer (GC) is significantly affected by distant metastases and postoperative recurrences. Bone metastasis one the worst prognostic in GC; however, its molecular mechanisms predictive biomarkers remain elusive. In prostate breast cancers, it has been reported that overexpression Cadherin 11 (CDH11), a mesenchymal cell-cell contact factor, known to be correlated with bone metastasis. Overexpression CDH11 mRNA bulk GC tissues also associated worse prognosis. However,...
Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a rare and devastating malignancy, preclinical studies are needed to evaluate potential therapeutic regimens. Here, we examined the antitumor effects of cisplatin (CDDP), etoposide (ETP) irinotecan (CPT-11) their combinations on GEP-NEC using three small-cell cell lines (pancreatic NEC, A99; esophageal TYUC-1; duodenum TCC-NECT-2). In vitro were conducted viability assays. vivo experiments in mice inoculated with A99 or TCC-NECT-2...
Pseudomyxoma peritonei is a rare disease condition mainly caused by primary mucinous tumors from the appendix and rarely ovary, such as when ovarian arise within teratoma. Molecular analyses of pseudomyxoma showed that KRAS GNAS pathogenic variants are common genetic features peritonei. However, origin difficult to be identified via alone. This study presents case origin, which was diagnosed comprehensive genomic profiling with ploidy analysis in series primary, recurrent, autopsy tumor...
Abstract Background Ectopic decidua is the presence of decidual tissue outside uterus. appendix a rare entity that can present with abdominal symptoms mimicking appendicitis. We report case 39-year-old female patient at 27 weeks gestational age 2-day history right lower quadrant pain. Case presentation The was referred to our hospital suspicion either acute appendicitis or threatened rupture uterus, latter which considered unlikely following close examination. Therefore, she underwent...