A5042646997- Gene expression and cancer classification
- Influenza Virus Research Studies
- Single-cell and spatial transcriptomics
- Genomics and Phylogenetic Studies
- Machine Learning in Bioinformatics
- Evolution and Genetic Dynamics
- Cancer-related gene regulation
- Digital Innovation in Industries
- Genetic diversity and population structure
- Inflammatory Bowel Disease
- RNA Research and Splicing
- Robotic Process Automation Applications
- Geology and Paleoclimatology Research
- vaccines and immunoinformatics approaches
- IL-33, ST2, and ILC Pathways
- Genetics, Bioinformatics, and Biomedical Research
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Acute Lymphoblastic Leukemia research
- Cell Image Analysis Techniques
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- ERP Systems Implementation and Impact
- Eosinophilic Esophagitis
Heinrich Heine University Düsseldorf
2013-2016
Helmholtz Centre for Infection Research
2015
Significance The link between species diversification and adaptation has long interested biologists working on multicellular eukaryotes, but remains poorly understood in prokaryotes, which diversity is much greater. We tested the hypothesis that associated with environmental Thaumarchaeota, an ancient abundant microbial group key player global nitrogen cycle. provide evidence Thaumarchaeota underwent a major radiation event hundreds of millions years ago coincided period pH adaptation....
Abstract Background and aims Treatment with tumor necrosis factor α (TNFα) antagonists in IBD patients suffers from primary non-response rates of up to 40%. Biomarkers for early prediction therapy success are missing. We investigated the dynamics gene expression DNA methylation blood samples treated TNF antagonist infliximab analyzed predictive potential regarding outcome. Methods performed a longitudinal, blood-based multi-omics study two prospective patient cohorts receiving first-time...
MiRNAs are discussed as diagnostic and therapeutic molecules. However, effective miRNA drug treatments with miRNAs are, so far, hampered by the complexity of networks. To identify potential drugs in colorectal cancer, we profiled mRNA expression matching normal, tumor metastasis tissues eight patients Illumina sequencing. We validated six a large tissue screen containing 16 additional entities identified miRNA-1, miRNA-129, miRNA-497 miRNA-215 constantly de-regulated within majority cancers....
Die Fähigkeit generativer Künstlicher Intelligenz (Gen-KI), über die Nutzung leistungsfähiger Large-Language-Modelle (LLMs) menschliche Sprache zu verstehen, komplexe Fragen beantworten, Programmcode schreiben oder Wissen zusammenzufassen, bietet neue Möglichkeiten für Automatisierung von Geschäftsprozessen [1]. zunehmende Multimodalität der LLMs im Generieren und Interpretieren Audio-, Bild- Videodaten eröffnet dabei auch vielversprechende Anwendungsgebiete jenseits reinen textbasierten...
Abstract Motivation: Ancestral character state reconstruction describes a set of techniques for estimating phenotypic or genetic features species related individuals that are the predecessors those present today. Such reconstructions can reach into distant past and provide insights history population when fossil data not available, they be used to test evolutionary hypotheses, e.g. on co-evolution traits. Typical methods ancestral continuous characters consider phylogeny underlying estimate...
Human influenza viruses are rapidly evolving RNA that cause short-term respiratory infections with substantial morbidity and mortality in annual epidemics. Uncovering the general principles of viral coevolution human hosts is important for pathogen surveillance vaccine design. Protein regions an appropriate model interactions between two macromolecules, but currently used epitope definition major antigen viruses, namely hemagglutinin, very broad. Here, we combined genetic, evolutionary,...
Recent technological advances enable genomics of individual cells, the building blocks all living organisms. Single cell data characteristics differ from those bulk data, which led to a plethora new analytical strategies. However, solutions are only useful for experts and currently, there no widely accepted gold standards single analysis. To meet requirements flexibility, ease use security, we developed FASTGenomics ( https://fastgenomics.org ) as powerful, efficient, versatile, robust, safe...
Zusammenfassung Die individuelle Zelle stellt die fundamentale Einheit des Lebens dar. Ihre Funktionsweise ist seit Jahrhunderten Gegenstand der biomedizinischen Forschung. Seit Kurzem erlaubt sogenannte Einzelzellsequenzierung revolutionäre neue Einblicke in Komposition von Geweben, Interaktion zwischen Zellen und den Ablauf dynamischer Prozesse. damit verbundenen Daten, z. B. aus Transkriptomik, stellen Analysten jedoch vor Herausforderungen. Daten sind typischerweise sehr groß, verrauscht...