A5005129576- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiac Ischemia and Reperfusion
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Transplantation: Methods and Outcomes
- Cardiovascular and exercise physiology
- Cardiac, Anesthesia and Surgical Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Glycogen Storage Diseases and Myoclonus
- Neuropeptides and Animal Physiology
- Cardiac Structural Anomalies and Repair
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Issues in Pregnancy
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Lysosomal Storage Disorders Research
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Chronic Lymphocytic Leukemia Research
- LGBTQ Health, Identity, and Policy
- Chronic Myeloid Leukemia Treatments
University of Utah
2016-2025
Vanderbilt University
2019
University of Massachusetts Boston
2017
Astellas Pharma (United States)
2015
University of Utah Hospital
2014
The University of Texas Medical Branch at Galveston
2007-2010
University of Arizona
1993-2008
Galveston College
2006
University of Virginia
1989-1993
Salem VA Medical Center
1987-1993
Early detection of coronary artery dysfunction is paramount cardiovascular clinical importance, but a noninvasive assessment lacking. Indeed, the brachial flow-mediated dilation test only weakly correlated with acetylcholine-induced function ( r=0.36). However, methodologies have, over time, substantially improved. This study sought to determine if updates this technique have improved relationship and indication dysfunction. Coronary were assessed in 28 patients referred for cardiac...
Binge drinking of alcohol causes cardiac dysfunction in some people. The mechanism remains unclear. This study was designed to investigate high doses alcohol-induced oxidative stress and apoptosis cardiomyocytes protective effects antioxidants. Cardiomyocytes isolated from 1- 2-day-old Sprague-Dawley rats were treated with ethanol at 0 mM, 50 100 200 mM for 24 hours. Vitamin E (1 mM) vitamin C (0.2 added medium 1 hour before addition ethanol. Results showed typical apoptosis: chromatin...
Ischemic heart disease and acute myocardial infarction (AMI) is a leading cause of morbidity mortality. Improvements have been made in coronary interventions to restore blood flow, but ischemia/reperfusion (I/R) injury significantly impacts clinical outcomes. We previously reported that activation percutaneous mechanical unloading the left ventricle (LV) with transvalvular axial-flow device simultaneously reperfusion improves salvage. However, underlying mechanisms, potential adjuvant...
We assessed whether aspirin (acetylsalicylic acid, ASA), administered before reperfusion, abrogates the infarct size (IS)-limiting effect of atorvastatin (ATV). Statins reduce IS. This dose-dependent is mediated by upregulation cycloxygenase-2 (COX2) and PGI(2) production. Administration selective COX2-inhibitors either with ATV for 3 days or immediately coronary occlusion blocks IS-limiting ATV. Sprague-Dawley rats received 3-day (10 mg x kg(-1) day(-1)) water alone. Rats underwent 30 min...
The purpose of this study was to determine whether intrinsic cardiac adrenergic (ICA) cells release calcitonin gene-related peptide (CGRP), exerting synergistic adrenopeptidergic cardioprotection. In situ hybridization coupled with immunostaining demonstrated that ICA exclusively expressed CGRP mRNA and co-expressed δ-opioid receptor in human rat left ventricular (LV) myocardium. Radioimmunoassay detected constitutive from hearts. agonist [D-Pen25]-enkephalin (DPDPE) increased denervated...
Stimulation of cardiac beta(2)-adrenergic receptor (beta(2)-AR) or delta-opioid (DOR) exerts a similar degree cardioprotection against myocardial ischemia in experimental models. We hypothesized that delta-opioid-initiated is mediated by the intrinsic adrenergic (ICA) cell via enhanced epinephrine release. Using immunohistochemical and situ hybridization methods, we detected tyrosine hydroxylase (TH) mRNA TH immunoreactivity was colocalized with DOR ICA cells human rat hearts. Western blot...
The present study tested the hypothesis that intracoronary (IC) propranolol improves clinical outcomes with percutaneous coronary intervention (PCI) when used background Gp IIb/IIIa receptor blockade.We have previously shown administration of a relatively large weight-based IC dose beta blocker before PCI decreases incidence post-PCI myocardial infarction (MI) and short- long-term outcome. It has been MI outcome.Patients undergoing (n = 400) were randomized in prospective double-blind...
A markedly elevated BB isoenzyme fraction of serum creatine kinase was noted in four male siblings and correlated with typical radiographic findings autosomal dominant osteopetrosis Type II (ADO II). Patients other sclerosing bone diseases had no elevation CK‐BB. The precision the electrophoretic mobility patterns correlation by I‐125 tagged radioimmunoassay method confirms that this is We postulate dysfunctional and/or immature osteoclasts ADO are more dependent on CK‐BB than usual...
Abstract A 43‐year‐old man with idiopathic hypereosinophilic syndrome survived a relatively long term (6 1/2 years) before he succumbed to intractable heart failure. Six months death, his chronic failure from restrictive cardiomyopathy was well compensated. Autopsy demonstrated severe constrictive pericarditis which not suspected antemortem. Constrictive as late complication of is discussed.