A5021716699- Air Quality and Health Impacts
- Gut microbiota and health
- Extracellular vesicles in disease
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Energy and Environment Impacts
- Stroke Rehabilitation and Recovery
- Probiotics and Fermented Foods
- Air Quality Monitoring and Forecasting
- Birth, Development, and Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Animal Nutrition and Physiology
- Climate Change and Health Impacts
- SARS-CoV-2 detection and testing
- Acute Ischemic Stroke Management
- Calcium signaling and nucleotide metabolism
- Fecal contamination and water quality
- Inhalation and Respiratory Drug Delivery
- Cardiac pacing and defibrillation studies
- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Circular RNAs in diseases
- Agriculture Sustainability and Environmental Impact
University of Milan
2017-2022
Adaptation Biologique et Vieillissement
2021
Education Trust
2021
Institut de Biologie Paris-Seine
2021
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2020
Institute for Community Health
2018
Abstract SARS-CoV-2 symptoms are non-specific and can range from asymptomatic presentation to severe pneumonia. Asymptomatic subjects carrying often remain undiagnosed it is still debated whether they develop immunoglobulins (Ig) how long persist. The aim of this study was investigate the development persistence antibodies against in infected by virus. This follow-up performed on 31 who presented a positive nasal swab or serology (Ig Spike-RBD) first part UNICORN (March 2020) aimed at...
Particulate matter (PM) exposure is linked to the worsening of respiratory conditions, including allergic rhinitis (AR), as it can trigger nasal and systemic inflammation. To unveil underlying molecular mechanisms, we investigated effects PM on release plasmatic extracellular vesicles (EV) complex cross-talk between host microbiome. this aim, evaluated PM10 PM2.5 exposures both bacteria-derived-EV portion (bEV) host-derived EVs (hEV), well bacterial microbiome (bNM) features in 26 AR...
Abstract The release of Extracellular Vesicles (EVs) into the bloodstream is positively associated with Particulate Matter (PM) exposure, which involved in endothelial dysfunction and related to increased risk cardiovascular disease. Obesity modifies effects PM exposure on heart rate variability markers inflammation, oxidative stress, acute phase response. We isolated characterized plasmatic EVs from six healthy donors confirmed a positive association exposure. stratified for Body Mass Index...
Abstract Regulation of gene expression can occur via epigenetic effects as mediated by DNA methylation. The potential for to be transmitted across generations, thus modulating phenotypic variation and affecting ecological evolutionary processes, is increasingly appreciated. However, the study in epigenomes inter-generational transmission alterations wild populations at its very infancy. We studied sex- age-related methylation parent-offspring resemblance profiles barn swallows. focused on a...
Air pollution exposure has been linked to modifications of both extracellular vesicle (EV) concentration and nasal microbiota structure (NMB), which might act as the respiratory health gatekeeper. This study aimed assess whether an unbalanced NMB could modify effect particulate matter (PM) on plasmatic EV levels. Due two different taxonomical profiles characterized by a widely relative abundance Moraxella genus, enrolled population was stratified into Mor− (balanced NMB) Mor+ (unbalanced...
Hypertensive disorders are common complications during pregnancy (HDP) with substantial public health impact. Acute and chronic particulate matter (PM) exposure increases the risk of HDP, although underlying molecular mechanisms remain unclear. Extracellular vesicles (EVs) may be ideal candidates for mediating effects PM in as they released response to environmental stimuli. The INSIDE project aims investigate this mechanism outcomes. study population is enrolled at Fetal Medicine Unit...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the disease 2019 (COVID-19), ranging from asymptomatic conditions to severe/fatal lung injury and multi-organ failure. Growing evidence shows that nasopharyngeal microbiota composition may predict severity of infections play a role in protection viral entry regulation immune response infection. In present study, we have characterized bacterial (BNM) performed factor analysis group 54 asymptomatic/paucisymptomatic...
Abstract The principal aim of the INSIDE project (INdividual air pollution exposure, extracellular vescicles SIgnaling and hypertensive disorder DEvelopment in pregnancy) is to assess molecular effects environmental exposure airborne particulate matter (PM) susceptible subject. Different approaches are considered evaluate these effects, including an exposure-effect study performed on a selected population. short-term different pollutants (PM NO 2 ) was evaluated considering 51 subjects...
<b>Background:</b> human microbiota plays a highly physiological role and influences health. Researches on structure functions are increasing, but is still largely unknown whether the airways influenced by airborne pollution, if it play in response to inhaled particulate matter (PM). <b>Aim:</b> we evaluated effects of PM respiratory healthy subjects. <b>Methods:</b> microbial community was examined through metabarcoding analysis V3-V4 16S rRNA gene regions amplified from upper-airway tracts...
Abstract Background: Increasing evidence suggests a possible link between the bacterial nasal microbiota (bNM) to allergic diseases such as Rhinitis (AR), it might modulate response by acting on onset and progression of inflammation. In this case-control study, we aimed compare bNM 25 AR patients matched healthy subjects (HS) well evaluate modifications within host-microbiota cross-talk, investigating release pattern both bacterial- host-Extracellular Vesicles (EVs). Results: analysis showed...
Trabajo presentado en el 24th International Pig Veterinary Society Congress, celebrado Dublin (Irlanda), del 7 al 10 de junio 2016
<h3>Introduction</h3> Inhaled particulate pollutants have been shown to produce systemic changes in DNA methylation. Global hypomethylation has associated viral sequence reactivation, possibly linked the activation of pro-inflammatory pathways occurring after exposure. We aimed at evaluating effects PM exposure on methylation Wp promoter Epstein-Barr Virus (EBV-Wp) and human-endogenous-retrovirus w (HERV-w), chosen as a paradigm an exogenous virus endogenous retroviral sequence, workers...
Background: Respiratory syncytial virus (RSV) ranks first among the causes of acute lower respiratory infections in children. The most common clinical syndrome associated with RSV infection is bronchiolitis (RSV-B). Air pollution might influence inflammatory cascade that brings to RSV-B.Aims: To investigate association between PM10 exposure and risk hospitalization for RSV-B.Methods: We selected hospital discharge records (HRD) ICD-9-CM code 466.11, referring infants <1 year age, occurring...
During pregnancy, the woman's immune system changes to support fetal development. These immunological modifications can increase risk of respiratory diseases. Because microbiome is involved in airway homeostasis, it important investigate how during pregnancy. Additionally, since parity associated with alterations and cohabitants shared a similar microbiome, we investigated whether having child may influence pregnant women. We compared 55 26 non-pregnant women using 16S rRNA gene sequencing...