A5024741522- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- Polyomavirus and related diseases
- Cancer Immunotherapy and Biomarkers
- Autoimmune Bullous Skin Diseases
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Fungal Infections and Studies
- Antenna Design and Analysis
- Colorectal Cancer Treatments and Studies
- Nail Diseases and Treatments
- Ocular Oncology and Treatments
- Vascular Tumors and Angiosarcomas
- Cancer Genomics and Diagnostics
- Full-Duplex Wireless Communications
- Plant Virus Research Studies
- Infectious Diseases and Mycology
- Chronic Lymphocytic Leukemia Research
- Genital Health and Disease
- melanin and skin pigmentation
The University of Texas MD Anderson Cancer Center
2016-2025
The University of Texas Health Science Center at Houston
2021-2025
Center for Translational Molecular Medicine
2023
Aneurin Bevan University Health Board
2022
University of Minnesota
2022
Memorial Sloan Kettering Cancer Center
2018-2022
Complejo Hospitalario de Navarra
2022
Brigham and Women's Hospital
2022
Oxfam
2022
John Wiley & Sons (United States)
2022
Abstract BACKGROUND: There is a need for improved prognostic markers in melanoma. In this study, the authors tested significance and clinicopathologic correlations of v‐raf murine sarcoma viral oncogene homolog B1 ( BRAF ) neuroblastoma RAS (v‐ ras NRAS mutations patients with metastatic METHODS: Clinical pathologic data were collected retrospectively on melanoma who clinically (exon 15) (exons 1 2) at The University Texas M. D. Anderson Cancer Center. Analyses performed to identify...
Abstract Purpose: Aggressive cutaneous squamous cell carcinoma (cSCC) is often a disfiguring and lethal disease. Very little currently known about the mutations that drive aggressive cSCC. Experimental Design: Whole-exome sequencing was performed on 39 cases of cSCC to identify driver genes novel therapeutic targets. Significantly, mutated were identified with MutSig or complementary methods developed specifically candidate tumor suppressors based upon their inactivating mutation bias....
We present a comparative study of calorimetrically derived thermodynamic profiles for the binding series drugs with selected DNA host duplexes. use these data to demonstrate that comparisons between complete (delta G zero, delta H S Cp) are required before drug can be used as probe conformation, since enthalpy-entropy compensations cause two drug-DNA events exhibit similar free energies zero) despite being driven by entirely different forces zero). In this work, we employ combination...
The polycythemic repression of erythropoiesis and the restoration by specific stimulation were studied in spleen colony system irradiated mice. 1. A 5 day period erythropoietin (exogenous erythropoietin) or (polycythemia) bone marrow donor only, does not significantly alter number type colonies formed transplanted cells. 2. Erythropoietin did endogenous mice receiving 580 R. markedly reduced growth but erythroid colonies, while affecting other types endogenously. 3. recipient during marrow....
<h3>Background</h3> Immune checkpoint therapy has dramatically changed the landscape of cancer therapy, providing an efficacious and durable therapeutic option for patients with advanced-stage disease. However, dermatologic toxicities are a well-recognized side effect in receiving this therapy. A spectrum immune related adverse events (irAEs) involving skin can occur include immunobullous disorders, lichenoid dermatitis, vitiligo. Granulomatous/sarcoid-like lesions now being recognized...
Monoclonal antibodies against the immune checkpoint programmed cell death receptor 1 (PD-1) improve hosts' antitumor response and have showed tremendous promise in treatment of advanced solid tumors hematologic malignancies. Reports serious autoimmune dermatologic toxicities from blockade therapy, however, are emerging. We report our experience with five patients who presented pruritic vesicles blisters on skin while treated anti-PD-1 antibody immunotherapy either nivolumab or pembrolizumab....
Abstract: Immunotherapy targeting the programmed cell death 1 (PD-1) receptor has demonstrated tremendous promise in treatment of advanced solid tumors. Dermatologic toxicities, however, are an emerging consequence this therapy and have been clearly associated with immune checkpoint blockade antibodies. Distinctive clinical histologic subtypes dermatologic toxicity secondary to immunotherapy include rare autoimmune bullous reactions (eg, pemphigoid) lichenoid eruptions. We report three...
Abstract Purpose: Merkel cell carcinoma (MCC) is an aggressive cancer with frequent metastasis and death few effective therapies. Because programmed ligand-1 (PD-L1) frequently expressed in MCC, immune checkpoint blockade has been leveraged as treatment for metastatic disease. There therefore a critical need to understand the relationships between MCPyV status, profiles, patient outcomes. Experimental Design: IHC CD3, CD8, PD-1, PD-L1, T-antigen (to determine status) was performed on 62...
Abstract Dermatologic toxicities are the most common immune-related adverse events (irAE) secondary to immune checkpoint inhibitors (ICI). First-line treatment for grade 3 or 4 skin irAEs is high-dose corticosteroids, which have their own side effects. Prolonged with corticosteroids may abrogate antitumor ICI activity. The cellular causes of these dermatologic toxicities, can manifest as a variety clinical presentations, remain unclear. Beyond steroids, recommended options limited. We report...
Although trichorhinophalangeal syndrome type 1 (TRPS1) was initially thought to be highly sensitive and specific for carcinomas mesenchymal tumors of mammary origin, more recent data suggest its expression is not limited breast neoplasms but also can seen in other cutaneous neoplasms, such as extramammary Paget disease squamous cell carcinoma (SCC) situ.
Purpose Immune checkpoint inhibitors (ICIs) are increasingly used to treat advanced malignancy but can induce immune-related adverse events (irAE). The mechanisms behind these sporadic and sometimes life-threatening irAEs remain largely unexplored. Here, we present a case report in-depth molecular analysis of an erythema nodosum (EN) like irAE occurring in melanoma patient with isolated brain metastasis, aiming explore the potential mechanism this irAE. Methods We performed RNA T cell...
Abstract Context.—A precise role for the innate immune system in psoriasis remains to be determined. Surface receptors, including Toll-like receptors (TLRs) that recognize bacterial ligands and CD91, which recognizes heat shock proteins (HSPs), are implicated both adaptive immunity. Objective.—Since skin is exposed various exogenous stimuli, can provoke or exacerbate psoriasis, we characterized expression function of TLRs, HSPs normal psoriatic skin. Design.—A variety skin-derived cells...
Abstract Context.—A precise role for the innate immune system in psoriasis remains to be determined. Surface receptors, including Toll-like receptors (TLRs) that recognize bacterial ligands and CD91, which recognizes heat shock proteins (HSPs), are implicated both adaptive immunity. Objective.—Since skin is exposed various exogenous stimuli, can provoke or exacerbate psoriasis, we characterized expression function of TLRs, HSPs normal psoriatic skin. Design.—A variety skin-derived cells...
Hotspot mutations in BRAF and NRAS are the most common somatic events patients with melanoma. These occur at highly conserved residues, but include several different substitutions. To determine whether specific clinically important to differentiate, tumor characteristics clinical outcomes were compared among advanced melanoma 1) V600E versus V600K 2) exon 1 2 mutations.Retrospective pathologic data collected for or mutations. The demographics, characteristics, of identify significant...
Vemurafenib and dabrafenib selectively inhibit the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) kinase, resulting in high response rates increased survival melanoma. Approximately 22% of individuals treated with vemurafenib develop cutaneous squamous cell carcinoma (cSCC) during therapy. The prevailing explanation for this is drug-induced paradoxical ERK activation, hyperproliferation. Here we show an unexpected novel effect vemurafenib/PLX4720 suppressing apoptosis through...
Sebaceous carcinoma (SC) is a rare but aggressive malignancy with frequent recurrence and metastases. Surgery the mainstay of therapy, effective systemic therapies are lacking because molecular alterations driving SC remain poorly understood. To identify these, we performed whole-exome next-generation sequencing 409 cancer-associated genes on 27 SCs (18 primary/locally recurrent ocular, 5 paired metastatic 4 primary extraocular) from 20 patients. In ocular SC, identified 139 non-synonymous...
Primary cutaneous gamma-delta (γδ) T-cell lymphoma is a rare disease that typically involves the dermis and subcutis. Cases of primary lymphomas showing γδ phenotype predominantly epidermotropic pattern (EγδTCL) are not well defined. In this series, cases were reviewed classified as when >75% cells resided in epidermis or dermal and/or subcutaneous (DSγδTCL). Clinical, pathologic, immunophenotypic features compared 27 biopsies from 13 patients EγδTCL 7 DSγδTCL. The diffusely positive for...
Trichorhinophalangeal syndrome type 1 (TPRS1) expression has been found to be highly sensitive and specific for breast carcinomas. The frequency of TRPS1 in cutaneous neoplasms such as mammary Paget disease (MPD) extramammary PD (EMPD) is currently unknown. We assessed the utility immunohistochemistry (IHC) evaluation MPD, EMPD, their histopathologic mimics, squamous cell carcinoma situ (SCCIS) melanoma (MIS).Twenty-four MPDs, 19 EMPDs, 13 SCCISs, 9 MISs were subjected immunohistochemical...